Results 71 to 80 of about 1,125,979 (313)

Intertwined Orders in Heavy-Fermion Superconductor CeCoIn$_5$

, 2016
The appearance of spin-density-wave (SDW) magnetic order in the low-temperature and high-field corner of the superconducting phase diagram of CeCoIn$_5$ is unique among unconventional superconductors.
Bauer, Eric D., Kenzelmann, Michel, Kim, Duk Y., Lin, Shi-Zeng, Movshovich, Roman, Ronning, Filip, Thompson, J. D., Weickert, Franziska   +7 more
core   +2 more sources

Endogenous topoisomerase II-mediated DNA breaks drive thymic cancer predisposition linked to ATM deficiency [PDF]

, 2020
The ATM kinase is a master regulator of the DNA damage response to double-strand breaks (DSBs) and a well-established tumour suppressor whose loss is the cause of the neurodegenerative and cancer-prone syndrome Ataxia-Telangiectasia (A-T).
Bernal Lozano, Cristina, Cortés Ledesma, Felipe, Delgado Sainz, Irene, García Quintanilla, Lourdes, Jimeno González, Silvia, Martínez García, Pedro Manuel, Quintero, Cristina, Romero Granados, Rocío, Serrano Benítez, Almudena, Terrón Bautista, José, Álvarez Quilón, Alejandro   +10 more
core   +3 more sources

Hypersensitivity to Cold Stimuli in Symptomatic Contact Lens Wearers [PDF]

Optometry and Vision Science, 2016
ABSTRACTPurposeTo examine the cooling thresholds and the estimated sensation magnitude at stimulus detection in controls and symptomatic and asymptomatic contact lens (CL) wearers, to determine whether detection thresholds depend on the presence of symptoms of dryness and discomfort.MethodsForty-nine adapted CL wearers and 15 non–lens wearing controls ...
Ping, Situ, Trefford, Simpson, Carolyn, Begley   +2 more
openaire   +2 more sources

MicroRNA‐375‐3p Targets Fatty Acid Synthase and Relish to Regulate Energy Allocation During Pupal Metamorphosis and Starvation

Advanced Science, EarlyView.
During pupal metamorphosis and starvation, elevated 20‐hydroxyecdysone (20E) and suppressed insulin trigger Forkhead box O (FOXO) nuclear translocation, enhancing miR‐375‐3p expression. This downregulates fatty acid synthase (FASN) and Relish, promoting lipid breakdown for energy while prioritizing antioxidant responses over immune functions to support
Peng Chen, Meiqi Cheng, Jianhui Wang, Jing Tang, Xiaoqiao Huang, Yusi Li, Huiling Zhou, Ling Zhang, Yi Dong, Chengjun Li, Bin Li   +10 more
wiley   +1 more source

VGLUT2 controls heat and punctuate hyperalgesia associated with nerve injury via TRPV1-Cre primary afferents. [PDF]

PLoS ONE, 2015
Nerve injury induces a state of prolonged thermal and mechanical hypersensitivity in the innervated area, causing distress in affected individuals. Nerve injury-induced hypersensitivity is partially due to increased activity and thereby sustained release
Katarzyna Rogoz, Ludvig Stjärne, Klas Kullander, Malin C Lagerström   +3 more
doaj   +1 more source

Cold hypersensitivity increases with age in mice with sickle cell disease. [PDF]

Pain, 2014
Zappia KJ, Garrison SR, Hillery CA, Stucky CL.   +3 more
europepmc   +2 more sources

Effects of L-citrulline diet on stress-induced cold hypersensitivity in mice. [PDF]

Pharmacognosy Res, 2014
Background: L-citrulline is an amino acid discovered in watermelon (Citrullus lanatus, Cucurbitaceae) and is a known component of the nitric oxide (NO) cycle that plays an important role in adjusting blood circulation and supplying NO and a key component
Kobayashi Y, Narita K, Chiba K, Takemoto H, Morita M, Morishita K.   +5 more
europepmc   +2 more sources

Evaluation of behavior in transgenic mouse models to understand human congenital pain conditions [PDF]

, 2018
BACKGROUND: Containing a brain for signal processing and decision making, and a peripheral component for sensation and response, the nervous system provides higher organisms a powerful method of interacting with their environment.
Bullock, Daniel
core  

Distinct subsets of unmyelinated primary sensory fibers mediate behavioral responses to noxious thermal and mechanical stimuli [PDF]

, 2009
Behavioral responses to painful stimuli require peripheral sensory neurons called nociceptors. Electrophysiological studies show that most C-fiber nociceptors are polymodal (i.e., respond to multiple noxious stimulus modalities, such as mechanical and ...
A. I. Basbaum, Abrahamsen, Barclay, Bautista, Bautista, Binshtok, Cain, Caterina, Caterina, Caterina, Caterina, Caterina, Chandrashekar, D. J. Anderson, D. J. Cavanaugh, Davis, Dong, Fitzgerald, Gamse, H. Lee, Holzer, Julius, Karai, L. Lo, Lawson, Lee, Lewinter, Luquet, M. J. Zylka, MELZACK, Molliver, Perl, Perl, Potrebic, Price, S. D. Shields, Saito, Story, Stucky, Tarpley, Vulchanova, Yaksh   +41 more
core   +4 more sources

CRISPLD2 Attenuates Intervertebral Disc Degeneration by Suppressing Oxidative Stress‐Induced Ferroptosis through the miR‐548I‐IL17A Axis

Advanced Science, EarlyView.
This study identifies CRISPLD2 as a key protector against IVDD. By regulating ferroptosis through the CRISPLD2–miR‐548I–IL17A axis, CRISPLD2 maintains NPCs homeostasis and reduces oxidative stress. Restoring CRISPLD2 expression effectively alleviates disc degeneration and highlights a promising therapeutic strategy for discogenic low back pain ...
Yangyang Shi, Fudong Li, Tianyi Zhao, Kaiqiang Sun, Danying Zhang, Chen Yan, Ximing Xu, Jingchuang Sun, Xulin Hu, Xin Yong, Jiangang Shi, Yuan Wang   +11 more
wiley   +1 more source