Results 81 to 90 of about 1,125,979 (313)

Lack of evidence for central sensitization in idiopathic, non-traumatic neck pain : a systematic review [PDF]

, 2015
Background: Chronic neck pain is a common problem with a poorly understood pathophysiology. Often no underlying structural pathology can be found and radiological imaging findings are more related to age than to a patient's symptoms.
Bramer, Wichor, Cagnie, Barbara, Danneels, Lieven, Dolphens, Mieke, Kregel, Jeroen, Kuipers, Mandy, Malfliet, Anneleen, Meeus, Mira, Nijs, Jo, Roussel, Nathalie   +9 more
core   +1 more source

DNA 3 '-Phosphatase Activity Is Critical for Rapid Global Rates of Single-Strand Break Repair following Oxidative Stress [PDF]

, 2009
Oxidative stress is a major source of chromosome single-strand breaks (SSBs), and the repair of these lesions is retarded in neurodegenerative disease. The rate of the repair of oxidative SSBs is accelerated by XRCC1, a scaffold protein that is essential
Breslin, Claire, Caldecott, Keith W
core   +2 more sources

Discovery of an Adaptive Neuroimmune Response Driving Itch and Fast Tick Removal with Implications for Preventing Pathogen Transmission

Advanced Science, EarlyView.
Doehl et al. discovered an adaptive neuroimmune mechanism that induces itch in tick‐exposed guinea pigs, enabling rapid tick removal. This itch‐induced tick removal (IITR) is mediated by an adaptive cellular immune response and is independent of IgG, IgE, or TRPV1.
Johannes S. P. Doehl, Tiago D. Serafim, Serena Doh, Charles S. Grugan, Eva Iniguez, Luana Rogerio, Ronja Frigard, Ranadhir Dey, Pedro Cecilio, Xinglong Gu, Pang‐Yen Tseng, Aline da Silva Moreira, Mahnaz Minai, James Oristian, Hans Ackerman, Steven Brooks, Caroline Percopo, Siu‐Ping Ng, Derron A. Alves, Lucas Tirloni, Jennifer M. Anderson, Adriana Marques, Fabiano Oliveira, Shaden Kamhawi, Daniel E. Sonenshine, José M. C. Ribeiro, Mark Hoon, Jesus G. Valenzuela   +27 more
wiley   +1 more source

VGluT3⁺ primary afferents play distinct roles in mechanical and cold hypersensitivity depending on pain etiology. [PDF]

J Neurosci, 2014
Sensory nerve fibers differ not only with respect to their sensory modalities and conduction velocities, but also in their relative roles for pain hypersensitivity.
Draxler P, Honsek SD, Forsthuber L, Hadschieff V, Sandkühler J.   +4 more
europepmc   +2 more sources

Crystal structure of a Fanconi anemia-associated nuclease homolog bound to 5′ flap DNA: basis of interstrand cross-link repair by FAN1 [PDF]

, 2014
Fanconi anemia (FA) is an autosomal recessive genetic disorder caused by defects in any of 15 FA genes responsible for processing DNA interstrand cross-links (ICLs).
Carr, Antony, Cho, Yunje, Etheridge, Thomas, Gwon, Gwang Hyeon, Jo, Aera, Kim, YoungChang, Kim, Youngran, Liu, Yaqi, Watson, Adam, Yuan, Fenghua, Zhang, Yanbin   +10 more
core   +1 more source

Cortical Somatostatin Neurons Regulate Seizure Susceptibility via MINAR1/Gαs–cAMP Signaling

Advanced Science, EarlyView.
Our study identifies MINAR1 as a novel regulator of cortical interneuron excitability and seizure susceptibility. MINAR1 is preferentially expressed in SST+ interneurons. Genetic ablation of MINAR1 leads to seizure hypersensitivity, reduced SST+ neuron excitability, and impaired Gαs–cAMP signaling, disrupting the E/I balance.
Wei‐Tang Liu, Zhi‐Bin Hu, Ling Hu, Yu‐Bing Wang, Qiong Zhang, Ning‐Ning Song, Xi‐Yue Liu, Jia‐Yin Chen, Hong‐Wen Zhu, Bing‐Yao Zhou, Yun‐Chao Tao, Li Zhao, Ze‐Xuan Li, Yi‐Wei Li, Jia‐Qi Chen, Si‐Xin Tu, Cong‐Cong Qi, Sai‐Dan Ding, Gang Peng, Lin Xu, Yu‐Qiang Ding   +20 more
wiley   +1 more source

VAMP7 regulates constitutive membrane incorporation of the cold-activated channel TRPM8

Nature Communications, 2016
The temperature-sensitive TRPM8 channel is essential for cold sensing and has been linked to pathological cold hypersensitivity. Here, the authors find TRPM8 insertion in the cell membrane is mediated by VAMP7 following atypical LAMP1-containing vesicle ...
Debapriya Ghosh, Silvia Pinto, Lydia Danglot, Ine Vandewauw, Andrei Segal, Nele Van Ranst, Melissa Benoit, Annelies Janssens, Rudi Vennekens, Pieter Vanden Berghe, Thierry Galli, Joris Vriens, Thomas Voets   +12 more
doaj   +1 more source

The clinicopathologic and immunohistochemical features of 60 cutaneous glomus tumor: a retrospective case series study [PDF]

Anais Brasileiros de Dermatologia
Background Glomus Tumor (GT) are benign neoplasms that originate from mesenchymal cells. It presents as tenderness and cold allodynia in the digits, especially in the subungual region.
Yuehua Sun, Ruiqun Qi, Ze Wu, Xiaodong Zhang, Jun Niu   +4 more
doaj   +1 more source

Oxidative stress mediates thalidomide-induced pain by targeting peripheral TRPA1 and central TRPV4

BMC Biology, 2020
Background The mechanism underlying the pain symptoms associated with chemotherapeutic-induced peripheral neuropathy (CIPN) is poorly understood. Transient receptor potential ankyrin 1 (TRPA1), TRP vanilloid 4 (TRPV4), TRPV1, and oxidative stress have ...
Francesco De Logu, Gabriela Trevisan, Ilaria Maddalena Marone, Elisabetta Coppi, Diéssica Padilha Dalenogare, Mustafa Titiz, Matilde Marini, Lorenzo Landini, Daniel Souza Monteiro de Araujo, Simone Li Puma, Serena Materazzi, Gaetano De Siena, Pierangelo Geppetti, Romina Nassini   +13 more
doaj   +1 more source

The prevalence and predictive factors of dentine hypersensitivity among adults in Turkey

BMC Oral Health, 2023
Aim This study sought to determine the prevalence of dentine hypersensitivity (DH) among adults in Turkey. Also, to ascertain the association between DH and both etiological predictors and demographic patient characteristics.
Gunseli Katirci, Esra Uzer Celik
doaj   +1 more source