Results 101 to 110 of about 429,185 (305)
Cold molecules in pulsed optical lattices
, 2005 We review recent theoretical studies on the dynamics of molecules in pulsed optical lattices. These lattices are periodic potential wells formed by the interaction between two counter propagating far-off resonant optical fields and the molecules. We show
Barker, P. F. +7 more
core +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
A versatile cold-molecule collider [PDF]
Nature, 2019 Superconducting magnets have been used to trap cold oxygen molecules and study their collisions. This method could lead to a better understanding of low-temperature interactions for a broad range of molecules. A way to study interactions of trapped molecules at low temperatures.
openaire +1 more source
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Experiments on ultra-cold Rb: Rydberg atoms and Rb2 molecules
, 2008 This thesis presents simulated and experimental results on ultra-cold Rb Rydberg atoms and ultra-cold Rb2 molecules formed through a photo-association process.
Heath Kitson (19117459)
core +1 more source
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Probing Cold Supersonic Jets with Optical Frequency Combs
MoleculesWe report high-resolution, cavity-enhanced direct frequency comb Fourier transform spectroscopy of cold acetylene (C2H2) molecules in a planar supersonic jet expansion.
Romain Dubroeucq +5 more
doaj +1 more source
COLD MOLECULES AND SPECTROSCOPY
, 2007 Author Institution: FRITZ-HABER-INSTITUT DER MAX-PLANCK-GESELLSCHAFT, FARADAYWEG 4-6, D-14195 BERLIN, GERMANYCold molecules offer fascinating possibilities for novel molecular physics and physical chemistry experiments, such as studying cold collisions ...
Schnell, Melanie +4 more
core
Molecular Oncology, EarlyView.Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski +12 more
wiley +1 more source
Identification and characterization of cell adhesion molecules controlling synapse stability [PDF]
, 2012 Neuronal circuits form the basis of a functional nervous system to process and integrate information and to react to environmental cues. The formation of functional synaptic connections between neurons is essential for the establishment of these circuits.
Enneking, Eva-Maria
core +1 more source