Results 91 to 100 of about 905,867 (296)
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Statistical Mechanics of an Optical Phase Space Compressor
, 2005 We describe the statistical mechanics of a new method to produce very cold atoms or molecules. The method results from trapping a gas in a potential well, and sweeping through the well a semi-permeable barrier, one that allows particles to leave but not ...
A. M Dudarev +9 more
core +3 more sources
A versatile cold-molecule collider [PDF]
Nature, 2019 Superconducting magnets have been used to trap cold oxygen molecules and study their collisions. This method could lead to a better understanding of low-temperature interactions for a broad range of molecules. A way to study interactions of trapped molecules at low temperatures.
openaire +1 more source
Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
Ferroelectric quantum phase transition with cold polar molecules
New Journal of Physics, 2015 We analyze a system of polar molecules in a one-dimensional optical lattice. By controlling the internal structure of the polar molecules with static electric and microwave fields, we demonstrate the appearance of a quantum phase transition into a ...
Markus Klinsmann +2 more
doaj +1 more source
Optimizing the density of Stark decelerated radicals at low final velocities: a tutorial review
EPJ Techniques and Instrumentation, 2017 The Stark deceleration technique can produce molecular beams with very low velocities. In order to maximize the density of decelerated molecules, experimental parameters such as the velocity, the velocity spread and the spatial spread of the initial ...
Dominik Haas +3 more
doaj +1 more source
Molecular Oncology, EarlyView.We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu +10 more
wiley +1 more source
Molecular laser cooling using serrodynes: implementation, characterization and prospects
New Journal of PhysicsAn important effort is currently underway to extend optical cycling and laser cooling to more molecular species. Significant challenges arise in particular when multiple nuclear spins give rise to complex, resolved hyperfine spectra, as is the case for ...
Felix Kogel +4 more
doaj +1 more source