Results 91 to 100 of about 429,185 (305)
Molecular Oncology, EarlyView.EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain +10 more
wiley +1 more source
Molecular Oncology, EarlyView.We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu +10 more
wiley +1 more source
Ferroelectric quantum phase transition with cold polar molecules
New Journal of Physics, 2015 We analyze a system of polar molecules in a one-dimensional optical lattice. By controlling the internal structure of the polar molecules with static electric and microwave fields, we demonstrate the appearance of a quantum phase transition into a ...
Markus Klinsmann +2 more
doaj +1 more source
Optimizing the density of Stark decelerated radicals at low final velocities: a tutorial review
EPJ Techniques and Instrumentation, 2017 The Stark deceleration technique can produce molecular beams with very low velocities. In order to maximize the density of decelerated molecules, experimental parameters such as the velocity, the velocity spread and the spatial spread of the initial ...
Dominik Haas +3 more
doaj +1 more source
Towards sympathetic cooling of large molecules: Cold collisions between benzene and rare gas atoms
, 2009 This paper reports on calculations of collisional cross sections for the complexes Z-CDH6 (X = 3He, 4He, Ne) at temperatures in the range 1)μK - 10K and shows that relatively large cross sections in the 103-105Å2 range are available for collisional ...
P Barletta +5 more
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Cold atoms and molecules [PDF]
, 2012 The ability to cool and trap atoms has revolutionized atomic and ultra-cold physics. Molecular physics is currently undergoing a similar transformation.
Zhao, Yongkai
core
Molecular Oncology, EarlyView.Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata +10 more
wiley +1 more source
Simultaneous deceleration of atoms and molecules in a supersonic beam
New Journal of Physics, 2015 A unique property of Zeeman effect based manipulation of paramagnetic particle’s motion is the ability to control velocities of both atoms and molecules.
Nitzan Akerman +5 more
doaj +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
A detailed account of the measurements of cold collisions in a molecular synchrotron
EPJ Techniques and Instrumentation, 2018 We have recently demonstrated a general and sensitive method to study low energy collisions that exploits the unique properties of a molecular synchrotron (Van der Poel et al., Phys Rev Lett 120:033402, 2018).
Aernout P. P. van der Poel +1 more
doaj +1 more source