Results 81 to 90 of about 1,093 (215)
FEBS Open Bio, EarlyView.This paper reveals how human lactoferrin–albumin fusion (hLF‐HSA) potently suppresses lung adenocarcinoma cell migration. hLF‐HSA upregulates NHE7, leading to Golgi alkalization, disruption of the Golgi secretome, downregulation of MMP1, and reversal of EMT. These findings suggest a novel Golgi‐targeting strategy to suppress cancer cell migration.
Hana Nopia +3 more
wiley +1 more source
Probing Cold Supersonic Jets with Optical Frequency Combs
MoleculesWe report high-resolution, cavity-enhanced direct frequency comb Fourier transform spectroscopy of cold acetylene (C2H2) molecules in a planar supersonic jet expansion.
Romain Dubroeucq +5 more
doaj +1 more source
YIPFα1A expression is regulated by multilayered molecular mechanisms
FEBS Open Bio, EarlyView.YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji +2 more
wiley +1 more source
A versatile cold-molecule collider [PDF]
Nature, 2019 Superconducting magnets have been used to trap cold oxygen molecules and study their collisions. This method could lead to a better understanding of low-temperature interactions for a broad range of molecules. A way to study interactions of trapped molecules at low temperatures.
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FEBS Open Bio, EarlyView.The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer +7 more
wiley +1 more source
Frontiers in Microbiology, 2015 Microbial biofilms have great negative impacts on the world’s economy and pose serious problems to industry, public health and medicine. The interest in the development of new approaches for the prevention and treatment of bacterial adhesion and biofilm ...
Rosanna ePapa +7 more
doaj +1 more source
Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs
FEBS Open Bio, EarlyView.Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner +7 more
wiley +1 more source
FEBS Open Bio, EarlyView.Abruptly changing from aerobic to anaerobic conditions (sudden anaerobization) induced growth inhibition and a significant increase in intracellular labile ferrous iron in the aerotolerant anaerobe Amphibacillus xylanus. We found that free flavins mediate efficient electron transfer from NADH to ferric iron under anaerobic conditions, suggesting that ...
Shinya Kimata +13 more
wiley +1 more source
Molecular laser cooling using serrodynes: implementation, characterization and prospects
New Journal of PhysicsAn important effort is currently underway to extend optical cycling and laser cooling to more molecular species. Significant challenges arise in particular when multiple nuclear spins give rise to complex, resolved hyperfine spectra, as is the case for ...
Felix Kogel +4 more
doaj +1 more source
Cold and Ultracold Polar Molecules
Frontiers in Optics 2008/Laser Science XXIV/Plasmonics and Metamaterials/Optical Fabrication and Testing, 2008 We report two experiments working with cold and ultracold polar molecules. First, magnetically trapped ground-state OH molecules are used for cold collisions. Second, we describe progress towards quantum degenerate gas of ground-state KRb molecules.
openaire +2 more sources