Results 61 to 70 of about 905,867 (296)
The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes
FEBS Letters, EarlyView.Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga +3 more
wiley +1 more source
Isotopologue-selective laser cooling of molecules
New Journal of PhysicsDirect laser cooling of molecules has made significant progress in recent years. However, the selective cooling and manipulation of generic molecular samples based on their isotopic composition, which is ubiquitous in atomic laser cooling, has not yet ...
Felix Kogel +4 more
doaj +1 more source
Tunable Holstein model with cold polar molecules
, 2011 We show that an ensemble of polar molecules trapped in an optical lattice can be considered as a controllable open quantum system. The coupling between collective rotational excitations and the motion of the molecules in the lattice potential can be ...
A. S. Alexandrov +5 more
core +1 more source
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
Animal, 2021 The homeostasis dysfunctions caused by cold stress remain a threat to intestinal health, particularly for young broiler chickens. We hypothesized that adenosine monophosphate-activated protein kinase (AMPK) was involved in the regulation of cold stress ...
H.J. Zhou +5 more
doaj +1 more source
Surface-induced heating of cold polar molecules
, 2008 We study the rotational and vibrational heating of diatomic molecules placed near a surface at finite temperature on the basis of macroscopic quantum electrodynamics.
E. A. Hinds +9 more
core +1 more source
Phase Space Manipulation of Cold Free Radical OH Molecules [PDF]
, 2003 We report bunching, slowing, and acceleration of a supersonically cooled beam of diatomic hydroxyl radicals (OH). \textit{In situ} observation of laser-induced fluorescence along the beam propagation path allows for detailed characterization of ...
Bochinski, J. R. +4 more
core +2 more sources
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Microwave Manipulation of Cold Molecules [PDF]
Physics, 2020 Interactions between molecules can be tuned using microwaves, a finding that could be leveraged for studying quantum systems.
openaire +1 more source
Molecular Oncology, EarlyView.Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon +9 more
wiley +1 more source