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Orthopaedic applications of cold physical plasma [PDF]

EFORT Open Reviews, 2023
Cold physical plasma (CPP) technology is of high promise for various medical applications. The interplay of specific components of physical plasma with living cells, tissues and organs on a structural and functional level is of paramount interest with ...
Lars Nonnenmacher, Maximilian Fischer, Lyubomir Haralambiev, Sander Bekeschus, Frank Schulze, Georgi I Wassilew, Janosch Schoon, Johannes C Reichert   +7 more
doaj   +4 more sources

Cold physical plasma treatment optimization for improved bone allograft processing [PDF]

Frontiers in Bioengineering and Biotechnology, 2023
In musculoskeletal surgery, the treatment of large bone defects is challenging and can require the use of bone graft substitutes to restore mechanical stability and promote host-mediated regeneration.
Maximilian Fischer, Emely Bortel, Janosch Schoon, Einar Behnke, Bernhard Hesse, Bernhard Hesse, Timm Weitkamp, Sander Bekeschus, Monika Pichler, Georgi I. Wassilew, Frank Schulze   +10 more
doaj   +5 more sources

Cold Physical Plasma-Mediated Fenretinide Prodrug Activation Confers Additive Cytotoxicity in Epithelial Cells [PDF]

Antioxidants, 2023
Cold physical plasma is a partially ionized gas operated at body temperature and utilized for heat-sensitive technical and medical purposes. Physical plasma is a multi-component system consisting of, e.g., reactive species, ions and electrons, electric ...
Mohsen Ahmadi, Debora Singer, Felix Potlitz, Zahra Nasri, Thomas von Woedtke, Andreas Link, Sander Bekeschus, Kristian Wende   +7 more
doaj   +2 more sources

Enhancing the Impact of Chemotherapy on Ewing Sarcoma Cells through Combination with Cold Physical Plasma. [PDF]

Int J Mol Sci, 2023
Although Ewing’s sarcoma (ES) is a rare, but very aggressive tumor disease affecting the musculoskeletal system, especially in children, it is very aggressive and difficult to treat. Although medical advances and the establishment of chemotherapy represent a turning point in the treatment of ES, resistance to chemotherapy, and its side effects ...
Nitsch A, Qarqash S, Römer S, Schoon J, Ekkernkamp A, Niethard M, Reichert JC, Wassilew GI, Tzvetkov MV, Haralambiev L.   +9 more
europepmc   +4 more sources

Effective combination of cold physical plasma and chemotherapy against Ewing sarcoma cells in vitro [PDF]

Scientific Reports
Ewing's sarcoma (ES) is the second most common bone tumor in children and adolescents and is highly malignant. Although the new chemotherapy has significantly improved the survival rate for ES from about 10 to 75%, the survival rate for metastatic tumors
Andreas Nitsch, Sara Qarqash, Sarah Römer, Janosch Schoon, Debora Singer, Sander Bekeschus, Axel Ekkernkamp, Georgi I. Wassilew, Mladen V. Tzvetkov, Lyubomir Haralambiev   +9 more
doaj   +4 more sources

Combined Application of Cold Physical Plasma and Chemotherapeutics against Chondrosarcoma Cells. [PDF]

Int J Mol Sci
Chondrosarcoma (CS) is a rare malignant bone sarcoma that primarily affects cartilage cells in the femur and pelvis. While most subtypes exhibit slow growth with a very good prognosis, some aggressive subtypes have a poorer overall survival. CS is known for its resistance to chemotherapy and radiotherapy, leaving surgery as the sole effective ...
Nitsch A, Qarqash S, Schulze F, Nonnenmacher L, Bekeschus S, Tzvetkov MV, Wassilew GI, Haralambiev L.   +7 more
europepmc   +4 more sources

Cold Atmospheric Pressure Plasma in Wound Healing and Cancer Treatment

Applied Sciences, 2020
Plasma medicine is gaining increasing attention and is moving from basic research into clinical practice. While areas of application are diverse, much research has been conducted assessing the use of cold atmospheric pressure plasma (CAP) in wound ...
Lars Boeckmann, Mirijam Schäfer, Thoralf Bernhardt, Marie Luise Semmler, Ole Jung, Gregor Ojak, Tobias Fischer, Kirsten Peters, Barbara Nebe, Brigitte Müller-Hilke, Christian Seebauer, Sander Bekeschus, Steffen Emmert   +12 more
doaj   +3 more sources

Cold Plasma Treatment Enhances Drought Tolerance of Alfalfa (Medicago sativa L.) Seeds by Modulating Physiological Responses and Transcriptomic Profiles [PDF]

Antioxidants
Drought stress is a major limiting factor for alfalfa (Medicago sativa L.) production in arid and semi-arid regions. Cold plasma treatment has emerged as a promising physical technology for improving seed germination and stress tolerance, but its ...
Weicheng Gong, Chunxu Qin, Zhiqing Song, Xiliang Hao, Aozhe Li, Yaxin Liu, Chengzhi Ma   +6 more
doaj   +2 more sources

Cold Physical Plasma Toxicity in Breast and Oral Squamous Carcinoma In Vitro and in Patient-Derived Cancer Tissue Ex Vivo

Applied Sciences, 2023
Breast cancer (BC) and oral squamous cell carcinoma (OSCC) are among the most common types of cancer, but current clinical outcomes remain unsatisfactory.
Fariba Saadati, Fahimeh Jahanbakhshi, Hamed Mahdikia, Fereshteh Abbasvandi, Hamid Ghomi, Nasrin Yazdani, Keyvan Aghazadeh, Steffen Emmert, Sander Bekeschus   +8 more
doaj   +1 more source

Non-Invasive Physical Plasma for Preventing Radiation Dermatitis in Breast Cancer: A First-In-Human Feasibility Study

Pharmaceutics, 2022
Radiation dermatitis (RD) is the most common acute side effect of breast irradiation. More than a century following the therapeutic utilisation of X-rays, potent preventative and therapeutic options are still lacking.
Cas Stefaan Dejonckheere, Adriana Torres-Crigna, Julian Philipp Layer, Katharina Layer, Shari Wiegreffe, Gustavo Renato Sarria, Davide Scafa, David Koch, Christina Leitzen, Mümtaz Ali Köksal, Thomas Müdder, Alina Abramian, Christina Kaiser, Andree Faridi, Matthias Bernhard Stope, Alexander Mustea, Frank Anton Giordano, Leonard Christopher Schmeel   +17 more
doaj   +1 more source