Results 61 to 70 of about 714,917 (255)

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

The martyrdom effect : when pain and effort increase prosocial contributions [PDF]

, 2011
Most theories of motivation and behavior (and lay intuitions alike) consider pain and effort to be deterrents. In contrast to this widely held view, we provide evidence that the prospect of enduring pain and exerting effort for a prosocial cause can ...
Bentham J., Berns G., Camerer C., Cormack M., Cryder C., Dickert S., Fields R. M., Glucklich A., Hull C. L., Kohn A., Ledyard J., Lewin S. B., Liu W., Oppenheimer D. M., Paolacci G., Proctor R. W., Reimers S., Rozin P., Slovic P., Small D. A., Smith M. E., Von Neumann J.   +21 more
core   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Evolution and Mechanism of Strong Squall Line Occurred in Zhejiang on 25 March 2024

应用气象学报
Based on conventional upper-air and surface observations, S-band dual-polarization radar data, cloud ground lightning positioning data, ERA5 reanalysis data (0.25°×0.25°), environmental conditions, evolution characteristics, structure and mechanism of ...
Shen Xiaoling, Sang Minghui, Zhang Cheng, Wu Zhuoheng   +3 more
doaj   +1 more source

How do convective cold pools influence the atmospheric boundary layer near two wind turbines in northern Germany? [PDF]

Wind Energy Science
With increasing wind energy in the German energy grid, it is crucial to better understand how particular atmospheric phenomena can impact wind turbines and the surrounding atmospheric boundary layer.
J. D. Thayer, G. Kilroy, N. Wildmann
doaj   +1 more source

Dehydration in the tropical tropopause layer: Implications from the UARS Microwave Limb Sounder [PDF]

, 2004
Measurements of H2O from the Microwave Limb Sounder (MLS) on the Upper Atmosphere Research Satellite (UARS) are used to investigate the structure of H2O in the near tropopause region and dehydration mechanisms in the tropical tropopause layer (TTL).
Barath, D. L. Wu, Dessler, Dessler, Elson, Gettelman, Gunson, H. C. Pumphrey, Hartmann, Holton, Holton, J. W. Waters, Jensen, Kuang, Mote, Mote, Nedoluha, Pumphrey, Randel, Randel, Read, Read, Reber, Reed, Reid, Rosenlof, Rosenlof, Russell, Seidel, Sherwood, Sherwood, Sherwood, Sherwood, W. G. Read, Wang, Waters, Webster, Yulaeva, Zeng   +38 more
core   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

External Drivers and Mesoscale Self‐Organization of Shallow Cold Pools in the Trade‐Wind Regime

Journal of Advances in Modeling Earth Systems
Recent observations of the trade‐wind regions highlight the covariability between cold‐pool properties and mesoscale cloud organization. Given the covariability of organization with cloud cover and albedo, this suggests a potential impact of cold pools ...
Pouriya Alinaghi, A. Pier Siebesma, Fredrik Jansson, Martin Janssens, Franziska Glassmeier   +4 more
doaj   +1 more source

Temperature conditions in the cold pool 1977-81: A comparison between Southern New England and New York transects [PDF]

, 1985
Expendable bathythermograph data collected by the Ships of Opportunity (SOOP) - Ocean Monitoring Program are analyzed for seasonal and inter-annual variations of the cold pool.
Cook, Steven K.
core  

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source