Results 61 to 70 of about 162,200 (291)

Formation of the southern Bay of Bengal cold pool

, 2016
A pool of relatively cooler water, called here as the southern Bay of Bengal cold pool, exists around Sri Lanka and southern tip of India during the summer monsoon.
Vinayachandran, PN, Behara, Ambica, Das, Umasankar   +2 more
core   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Role of surface heat fluxes underneath cold pools [PDF]

Geophysical Research Letters, 2016
AbstractThe role of surface heat fluxes underneath cold pools is investigated using cloud‐resolving simulations with either interactive or horizontally homogenous surface heat fluxes over an ocean and a simplified land surface. Over the ocean, there are limited changes in the distribution of the cold pool temperature, humidity, and gust front velocity,
Gentine, Pierre, Garelli, Alix, Park, Seung‐Bu, Nie, Ji, Torri, Giuseppe, Kuang, Zhiming   +5 more
openaire   +4 more sources

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Evolution and Mechanism of Strong Squall Line Occurred in Zhejiang on 25 March 2024

应用气象学报
Based on conventional upper-air and surface observations, S-band dual-polarization radar data, cloud ground lightning positioning data, ERA5 reanalysis data (0.25°×0.25°), environmental conditions, evolution characteristics, structure and mechanism of ...
Shen Xiaoling, Sang Minghui, Zhang Cheng, Wu Zhuoheng   +3 more
doaj   +1 more source

Glucose supplementation improves intestinal amino acid transport and muscle amino acid pool in pigs during chronic cold exposure

Animal Nutrition, 2023
Mammals in northern regions chronically suffer from low temperatures during autumn-winter seasons. The aim of this study was to investigate the response of intestinal amino acid transport and the amino acid pool in muscle to chronic cold exposure via Min
Teng Teng, Xin Song, Guodong Sun, Hongwei Ding, Haoyang Sun, Guangdong Bai, Baoming Shi   +6 more
doaj   +1 more source

Surface Characteristics of Observed Cold Pools

Monthly Weather Review, 2008
Abstract Cold pools are a key element in the organization of precipitating convective systems, yet knowledge of their typical surface characteristics is largely anecdotal. To help to alleviate this situation, cold pools from 39 mesoscale convective system (MCS) events are sampled using Oklahoma Mesonet surface observations.
Engerer, Nicholas, Stensrud, David J., Coniglio, Michael C.   +2 more
openaire   +2 more sources

Dynamics and spatio-temporal variability of the Mid-Atlantic Bight Cold Pool

, 2018
The Mid-Atlantic Bight (MAB) Cold Pool is a bottom-trapped cold (lower than 10 °C) and fresh (lower than 34 psu) water mass, that is isolated from the surface by the seasonal thermocline, and is located over the mid- and outer-shelf of the MAB.

core   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source