Results 51 to 60 of about 714,917 (255)
Perceptions towards aqua-based exercise among older adults with osteoarthritis who have discontinued participation in this exercise mode [PDF]
, 2016 Aim: This study aimed to investigate reasons for ceasing participation in aqua-based exercise among older adults with osteoarthritis (OA). Methods: Eleven adults over 60 years of age with OA participated in one of two focus groups, during which they ...
Alpass +27 more
core +1 more source
The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity
Molecular Oncology, EarlyView.Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli +7 more
wiley +1 more source
Factors controlling Arctic denitrification in cold winters of the 1990s
, 2002 International audienceDenitrification of the Arctic winter stratosphere has been calculated using a 3-D microphysical model for the winters 1994/95, 1995/96, 1996/97 and 1999/2000.
Carslaw, K. S. +3 more
core +3 more sources
Molecular Oncology, EarlyView.Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova +25 more
wiley +1 more source
Journal of Lipid Research, 2022 Plasma lipid levels are altered in chronic conditions such as type 2 diabetes and cardiovascular disease as well as during acute stresses such as fasting and cold exposure.
Raghav Jain +4 more
doaj +1 more source
Post-test simulation of a PLOFA transient test in the CIRCE-HERO facility [PDF]
, 2019 CIRCE is a lead–bismuth eutectic alloy (LBE) pool facility aimed to simulate the primary system of a heavy liquid metal (HLM) cooled pool-type fast reactor.
Caruso G. +4 more
core +1 more source
COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells
Molecular Oncology, EarlyView.This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos +6 more
wiley +1 more source
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
Animal Nutrition, 2023 Mammals in northern regions chronically suffer from low temperatures during autumn-winter seasons. The aim of this study was to investigate the response of intestinal amino acid transport and the amino acid pool in muscle to chronic cold exposure via Min
Teng Teng +6 more
doaj +1 more source
Performance of a building integrated collector for solar heating and radiant cooling [PDF]
, 2011 Due to their limited temperature range, unglazed solar collectors have long been relegated to providing low cost heating in applications such as swimming pool heating systems.
Anderson, Timothy Nicholas +2 more
core +1 more source