Results 51 to 60 of about 162,200 (291)

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

How Variable Are Cold Pools?

Geophysical Research Letters
Cold pools formed by precipitating convective clouds are an important source of mesoscale temperature variability. However, their sub‐mesoscale (100 m–10 km) structure has not been quantified, impeding validation of numerical models and understanding of ...
Leah D. Grant, Bastian Kirsch, Jennie Bukowski, Nicholas M. Falk, Christine A. Neumaier, Mirjana Sakradzija, Susan C. van denHeever, Felix Ament   +7 more
doaj   +1 more source

Simulation and Analysis of the Mesoscale Vortex Affecting the “21·7” Extreme Rainstorm in Henan

Remote Sensing
From 17 to 22 July 2021, the “21·7” extreme rainfall event (“21·7” ERE) hit Henan Province, breaking the record for mainland China with a maximum hourly rainfall of 201.9 mm at the Zhengzhou station. The long-lived (20 h) mesoscale Huang-Huai vortex (HHV)
Lan Xu, Tao Chen, Juanjuan Liu, Shenming Fu, Wei Cheng, Hongbo Liu, Bing Lu, Yujun He, Shujun Zhu, Yiran Liu, Xiao Shen, Bin Wang   +11 more
doaj   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

A Comparative Analysis of the Synoptic Conditions and Thermodynamics of Two Thundersnow Weather Events in Shaanxi Province, China, During 2023

Atmosphere
This study presents a comparative analysis of two rare thundersnow events accompanied by snowfall that occurred on 11 November 2023 and 10 December 2023 in Shaanxi province, China. Multiple data sources were integrated, including MICAPS surface and upper-
Yueqi Li, Hongbo Ni, Jialu Liu, Yan Chou, Xinkai Hao, Shaoyang Liu   +5 more
doaj   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Research on Behavior of Natural Circulation of Coolant in Primary Circuit System of Pool Type Fast Reactor

Yuanzineng kexue jishu
Thermal-hydraulic phenomenon of coolant in the primary circuit of pool type fast reactor under accident decay heat removal conditions is complicated because the layout of direct heat exchanger.
CHENG Daoxi, ZHANG Xuefeng, DU Kaiwen, ZHAI Weiming, QI Xiaoguang, ZHOU Ping, YU Song, MA Xiaoyao, LI Ruizhi
doaj   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Determination of tissue contributions to the circulating lipid pool in cold exposure via systematic assessment of lipid profiles

Journal of Lipid Research, 2022
Plasma lipid levels are altered in chronic conditions such as type 2 diabetes and cardiovascular disease as well as during acute stresses such as fasting and cold exposure.
Raghav Jain, Gina Wade, Irene Ong, Bhagirath Chaurasia, Judith Simcox   +4 more
doaj   +1 more source