Results 41 to 50 of about 65,160 (249)

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

Cold Pools Reduce the Impacts of Deforestation on Convection Initiation

Atmospheric Science Letters
The individual and synergistic impacts of cold pools and land surface heterogeneity on convection initiation are investigated. Idealized large eddy simulations of deep convection over the Amazon rainforest are conducted.
Nicholas M. Falk, Gabrielle R. Leung, Leah D. Grant, Susan C. van denHeever   +3 more
doaj   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Simulations of a cold-air pool associated with elevated wintertime ozone in the Uintah Basin, Utah [PDF]

Atmospheric Chemistry and Physics, 2015
Numerical simulations are used to investigate the meteorological characteristics of the 31 January–6 February 2013 cold-air pool in the Uintah Basin, Utah, and the resulting high ozone concentrations.
E. M. Neemann, E. T. Crosman, J. D. Horel, L. Avey   +3 more
doaj   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Assessment of valley cold pools and clouds in a very high-resolution numerical weather prediction model [PDF]

Geoscientific Model Development, 2015
The formation of cold air pools in valleys under stable conditions represents an important challenge for numerical weather prediction (NWP). The challenge is increased when the valleys that dominate cold pool formation are on scales unresolved by NWP ...
J. K. Hughes, A. N. Ross, S. B. Vosper, A. P. Lock, B. C. Jemmett-Smith   +4 more
doaj   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Cold pool propagation and cold pool-land surface interactions

Convective cold pools are important components of the Earth system as they influence processes such as deep convective initiation, storm longevity and intensity, surface energy fluxes, and aerosol transport. The overarching goal of the research outlined in this dissertation is to investigate the propagation characteristics of cold pools, as well as the
Falk, Nicholas Michael, author, van den Heever, Susan C., advisor, Grant, Leah D., advisor, Bell, Michael M., committee member, Schumacher, Russ S., committee member, Venayagamoorthy, Subhas K., committee member   +5 more
openaire   +1 more source

Strong and weak cold pool collisions

, 2022
Collisions between convective cold pools commonly initiate new convective storms. This occurs through enhancements to the vertical velocity through mechanical forcing, and increased water vapor content via thermodynamic forcing. The goal of this study is to investigate the impact of the following four parameters on the mechanical and thermodynamic ...
Falk, Nicholas Michael, author, van den Heever, Susan C., advisor, Schumacher, Russ S., committee member, Venayagamoorthy, Subhas K., committee member   +3 more
openaire   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source