Results 61 to 70 of about 66,872 (284)

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

The Sugar‐To‐Flower Shallow Cumulus Transition Under the Influences of Diel Cycle and Free‐Tropospheric Mineral Dust

Journal of Advances in Modeling Earth Systems, 2023
A shallow cumulus cloud transition from a sugar to flower type of organization occurred under a layer of mineral dust on 2 February 2020, during the multinational Atlantic Tradewind Ocean‐Atmosphere Mesoscale Interaction Campaign (ATOMIC) and the ...
Pornampai Narenpitak, Jan Kazil, Takanobu Yamaguchi, Patricia K. Quinn, Graham Feingold   +4 more
doaj   +1 more source

Surface Characteristics of Observed Cold Pools

Monthly Weather Review, 2008
Abstract Cold pools are a key element in the organization of precipitating convective systems, yet knowledge of their typical surface characteristics is largely anecdotal. To help to alleviate this situation, cold pools from 39 mesoscale convective system (MCS) events are sampled using Oklahoma Mesonet surface observations.
Engerer, Nicholas, Stensrud, David J., Coniglio, Michael C.   +2 more
openaire   +2 more sources

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

The Role of Cold Pools in Modulating Convective Organization During the MJO

Geophysical Research Letters
In this study, we investigate the role of cold pools in modulating convective organization throughout the Madden‐Julian Oscillation (MJO) life cycle using a modeling approach that combines Eulerian and Lagrangian techniques.
Mingyue Tang, Giuseppe Torri, Naoko Sakaeda   +2 more
doaj   +1 more source

Meteorological Events Affecting Cold-Air Pools in a Small Basin

, 2011
Meteorological events affecting the evolution of temperature inversions or cold-air pools in the 1-km-diameter, high-altitude (~1300 m MSL) Grünloch basin in the eastern Alps are investigated using data from lines of temperature dataloggers running up ...
C. David Whiteman, Manfred Dorninger, Bernhard Pospichal, Stefan Eisenbach, Reinhold Steinacker, Benedikt Bica   +5 more
core   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

The Impact of Variable Land‐Atmosphere Coupling on Convective Cloud Populations Observed During the 2016 HI‐SCALE Field Campaign

Journal of Advances in Modeling Earth Systems, 2019
We use a large‐eddy simulation model with a nested domain configuration (297 and 120 km wide) and an interactive land surface parameterization to simulate the complex population of shallow clouds observed on 30 August 2016 during the Holistic ...
Jerome D. Fast, Larry K. Berg, Zhe Feng, Fan Mei, Rob Newsom, Koichi Sakaguchi, Heng Xiao   +6 more
doaj   +1 more source

Convective self‐aggregation, cold pools, and domain size [PDF]

Geophysical Research Letters, 2013
Convective self‐aggregation refers to a phenomenon in cloud‐resolving simulations wherein the atmosphere spontaneously develops a circulation with a convecting moist patch and a nonconvecting dry patch. All previous studies have found a sharp transition to aggregated convection when the domain size exceeds a critical threshold, typically in the range ...
Nadir Jeevanjee, David M. Romps
openaire   +3 more sources

Tropical oceanic mesoscale cold pools in observations and models

, 2021
Convective cold pools over oceans contribute to the atmosphere-ocean exchange of heat and moisture across the globe. Beyond cold pools’ physical properties, cold pools and their intersections are important mechanisms controlling the life cycle of ...
Garg, Piyush
core