Results 71 to 80 of about 66,872 (284)

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Detecting Cold Pool Family Trees in Convection Resolving Simulations

Journal of Advances in Modeling Earth Systems
Recent observations and modeling increasingly reveal the key role of cold pools in organizing the convective cloud field. Several methods for detecting cold pools in simulations exist, but are usually based on buoyancy fields and fall short of reliably ...
Jannik Hoeller, Romain Fiévet, Jan O. Haerter   +2 more
doaj   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

Molecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski, Liudmyla Dolinchuk, Michał Jerzak, Albert Gandurski, Tomasz Grochowski, Weronika Wojtyś, Maciej Zadrożny, Wojciech Kaźmierczak, Małgorzata Lenarcik, Marta Matejak‐Górska, Radosław Samsel, Tomasz Olesiński, Dawid Walerych   +12 more
wiley   +1 more source

Cold pool processes in different environments

, 2018
Cold pools are localized regions of dense air near Earth's surface. They form in association with precipitating clouds in many environments ranging from moist tropical to semi-arid continental conditions, and they play important roles in weather in climate. The overarching goal of this dissertation research is to improve our process-level understanding
Grant, Leah Danielle, author, van den Heever, Susan C., advisor, Randall, David A., committee member, Rutledge, Steven A., committee member, Niemann, Jeffrey D., committee member   +4 more
openaire   +1 more source

Morphology and growth of convective cold pools observed by a dense station network in Germany

, 2023
This study explores the morphology of convective cold pools, that is, their size, shape, and structure, as well as factors controlling their growth using surface-based observations of the Field Experiment on Sub-mesoscale Spatio Temporal Variability in ...
Kirsch, B., Hohenegger, C. ; https://orcid.org/, Ament, F.   +2 more
core   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Atmospheric cold pools abruptly reverse thermohaline features in the ocean skin layer [PDF]

Ocean Science
The ocean skin layer, which covers the upper millimetre of the sea surface, regulates the exchange of heat, gases, and freshwater between the atmosphere and the ocean.
L. Gassen, S. M. Ayim, L. Jaeger, J. Meyerjürgens, M. Ribas-Ribas, O. Wurl   +5 more
doaj   +1 more source

Cold Pools and Their Influence on the Tropical Marine Boundary Layer

, 2017
Cold pools dominate the surface temperature variability observed over the central Indian Ocean (0°, 80°E) for 2 months of research cruise observations in the Dynamics of the Madden–Julian Oscillation (DYNAMO) experiment in October–December 2011.
de Szoeke, Simon P, Skyllingstad, Eric D, Chandra, Arunchandra S, Zuidema, Paquita   +3 more
core   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source