Results 51 to 60 of about 65,160 (249)

What levels of estrogen hormones can be found in swimming pool water?

Applied Water Science, 2019
Estrogens are a group of sex hormones. The entry of this hormone into the human body causes premature puberty, breast, and uterus cancer, etc. Due to sustainability, harmful effects, and its skin absorption, the identification of this hormone in swimming
Nagma Roshan, Mohammad Mehdi Taghizadeh
doaj   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

The Sugar‐To‐Flower Shallow Cumulus Transition Under the Influences of Diel Cycle and Free‐Tropospheric Mineral Dust

Journal of Advances in Modeling Earth Systems, 2023
A shallow cumulus cloud transition from a sugar to flower type of organization occurred under a layer of mineral dust on 2 February 2020, during the multinational Atlantic Tradewind Ocean‐Atmosphere Mesoscale Interaction Campaign (ATOMIC) and the ...
Pornampai Narenpitak, Jan Kazil, Takanobu Yamaguchi, Patricia K. Quinn, Graham Feingold   +4 more
doaj   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

The Role of Cold Pools in Modulating Convective Organization During the MJO

Geophysical Research Letters
In this study, we investigate the role of cold pools in modulating convective organization throughout the Madden‐Julian Oscillation (MJO) life cycle using a modeling approach that combines Eulerian and Lagrangian techniques.
Mingyue Tang, Giuseppe Torri, Naoko Sakaeda   +2 more
doaj   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

The Impact of Variable Land‐Atmosphere Coupling on Convective Cloud Populations Observed During the 2016 HI‐SCALE Field Campaign

Journal of Advances in Modeling Earth Systems, 2019
We use a large‐eddy simulation model with a nested domain configuration (297 and 120 km wide) and an interactive land surface parameterization to simulate the complex population of shallow clouds observed on 30 August 2016 during the Holistic ...
Jerome D. Fast, Larry K. Berg, Zhe Feng, Fan Mei, Rob Newsom, Koichi Sakaguchi, Heng Xiao   +6 more
doaj   +1 more source

Convective self‐aggregation, cold pools, and domain size [PDF]

Geophysical Research Letters, 2013
Convective self‐aggregation refers to a phenomenon in cloud‐resolving simulations wherein the atmosphere spontaneously develops a circulation with a convecting moist patch and a nonconvecting dry patch. All previous studies have found a sharp transition to aggregated convection when the domain size exceeds a critical threshold, typically in the range ...
Nadir Jeevanjee, David M. Romps
openaire   +3 more sources

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Detecting Cold Pool Family Trees in Convection Resolving Simulations

Journal of Advances in Modeling Earth Systems
Recent observations and modeling increasingly reveal the key role of cold pools in organizing the convective cloud field. Several methods for detecting cold pools in simulations exist, but are usually based on buoyancy fields and fall short of reliably ...
Jannik Hoeller, Romain Fiévet, Jan O. Haerter   +2 more
doaj   +1 more source