Results 91 to 100 of about 1,190,556 (287)

Toward Personalized Theranostics: A Modular PET Platform for Antibody‐Based Imaging and Therapy

Advanced Science, EarlyView.
This modular, site‐specific antibody platform enables customizable conjugates for PET imaging and therapy. Interchangeable payloads – including radiometals, cytotoxics, and fluorophores – support adaptable, multimodal applications with limited off‐target effects. In vivo, the DFO/DOTAGA bischelate immunoconjugate provided clear tumor delineation in PET/
Delphine Vivier, Megane Grah Kple, Julen Ariztia, Marion Leroux, Mathieu Moreau, Michael Claron, Maxime Cheveau, Adam Laouafa, Agnieszka Kownacka, Camille Petitot, John Simonet, Alexandre M. M. Dias, Sophie Poty, Charles Truillet, Bertrand Collin, Alexandra Oudot, Franck Denat   +16 more
wiley   +1 more source

Statistical Analysis of the Tensile Strength of Cold Recycled Cement-Treated Materials and Its Influence on Pavement Design

Infrastructures
The tensile behavior of cold recycled cement-treated mixtures (CRCTMs), typically produced through full-depth reclamation (FDR), is critical for pavement design.
William Fedrigo, Thaís Radünz Kleinert, Gabriel Grassioli Schreinert, Lélio Antônio Teixeira Brito, Washington Peres Núñez   +4 more
doaj   +1 more source

Effects of Activated Cold Regenerant on Pavement Properties of Emulsified Asphalt Cold Recycled Mixture

Materials
Limited recovery of the viscoelastic properties of aged asphalt on RAP surfaces at ambient temperature reduces interface fusion and bonding with new emulsified asphalt, degrading pavement performance and limiting large-scale promotion and high-value applications of the emulsified asphalt cold recycled mixture (EACRM).
Chen, Fuda, Yu, Jiangmiao, Zhang, Yuan, Lin, Zengyao, Liu, Anxiong   +4 more
openaire   +3 more sources

Deubiquitination of Vangl by USP6 and USP32 Regulates Planar Cell Polarity Signaling

Advanced Science, EarlyView.
Compartment‐specific deubiquitination controls Vangl dosage and planar cell polarity signaling. USP6 and USP32 regulate distinct subcellular pools of Vangl by removing distinct ubiquitin modifications from Vangl proteins. This regulatory mechanism safeguards PCP‐dependent embryonic morphogenesis, while aberrant USP32‐dependent stabilization of VANGL ...
Fangzi Zha, Di Feng, Ziru Xue, Zhiying Liu, Xiaochen Lin, Zhe Wang, Ling Xu, Jasper Fuk Woo Chan, Martin Cheung, Michael Shing Yan Huen, Yusong Guo, Kui Ming Chan, Yun Liu, Bo Gao   +13 more
wiley   +1 more source

Evaluation of properties of mineral-cement-emulsion mixtures after 10 years of performance in field test sections

Roads and Bridges
In recent years, cold recycling using mineral-cement-emulsion (MCE) mixtures has become a common practice in the reconstruction of the old, deteriorated roads.
Bohdan Dołżycki, Cezary Szydłowski, Mariusz Jaczewski   +2 more
doaj   +1 more source

RECYCLING WITH ENDOGENEOUS CONSUMER PARTICIPATION [PDF]

We show that the cost of sorting and the network effects jointly determine the rate of participation of consumers in the process of recycling. The dominant producer of virgin material takes into account the recycling activities when it makes its pricing ...
Soham Baksi, Ngo Van Long
core   +2 more sources

Bone Marrow Macrophage STING Signaling is a Direct Nexus Linking Marrow Adipose Expansion to NAD+ Depletion and Osteogenic Decline in Skeletal Aging

Advanced Science, EarlyView.
This study reveals that during skeletal aging, bone marrow adipocyte‐derived sDPP4 primes STING signaling in macrophages. In combination with mitochondrial DNA, this signaling activates CD38 and depletes local NAD+/NMN, thereby impairing osteogenesis.
Zhichao Li, Kuanhui Gao, Mengjie Wang, Songlin Liang, Dandan Li, Guoqing Tan, Haipeng Xue, Yujie Liu, Peng Zhang, Zhanwang Xu, Wenxiang Cheng, Yongjun Wang, Nianhu Li   +12 more
wiley   +1 more source

Cold-In-Place Asphalt Recycling

, 2020
Recikliranje asfaltnih kolnika je ponovno korištenje materijala postojećih asfaltnih kolničkih konstrukcija. Metode recikliranja ovisno o mjestu recikliranja dijelimo na „in situ“ i „in plant“ postupak, a ovisno o temperaturi reciklirane mješavine ...
Mrak, Sven
core  

Molecular Glue Degraders Enhance CAPRIN1‐Dependent Lysosomal Degradation of APP and Reduce Amyloid β in Alzheimer's Disease

Advanced Science, EarlyView.
A new class of lysosome‐directed molecular glue degraders selectively enhance CAPRIN1–APP interactions, driving APP degradation and reducing amyloid‐β production in human neurons and Alzheimer's disease mouse models. This CAPRIN1‐dependent targeted protein degradation strategy reveals a previously unrecognized therapeutic approach for disrupting the ...
Sunghan Jung, Xu Wang, Bin Liu, Raktim Roy, Nancy Jaiswal, Ratan K. Rai, Yuichiro Takagi, Cen Gao, Lifan Zeng, Ho‐Yin Lo, Reagan K. Wohlford, Ryan K. Higgins, Bruce T. Lamb, Anantha Shekhar, Anita C. Bellail, Chunhai Hao   +15 more
wiley   +1 more source

Application of water-organic emulsions for the recovery of asphalt concrete

MATEC Web of Conferences, 2018
Old asphalt utilization by means of its recycling and re-use in road construction is becoming increasingly important. Its technical and economic efficiency is proved and, in some countries, it reaches ten millions of tons per year.
Shestakov Nikolay, Putilin Sergei
doaj   +1 more source