Results 111 to 120 of about 1,190,556 (287)

A review of the composition, regeneration mechanism, and performance of cold recycled asphalt mixture

open access: yesJournal of Traffic and Transportation Engineering (English ed. Online)
This review aims to enhance the mechanical and road performance of cold recycled asphalt mixture, and advocate the application of cold recycling technology, which features lower energy consumption and reduced carbon emissions.
Long Wen   +6 more
doaj   +1 more source

TROP2‐Targeting Chimeras (TRTACs) for Tumor Cell‐Selective Membrane Protein Degradation and Enhanced Drug Delivery

open access: yesAdvanced Science, EarlyView.
TROP2 is identified as a novel tumor‐selective lysosomal‐targeting receptor with established clinical relevance. TROP2‐targeting chimeras (TRTACs) are developed by genetically fusing a TROP2‐binding nanobody to nanobodies against specific target proteins.
Luping Chen   +10 more
wiley   +1 more source

Structural Evaluation of Cold Recycling Reclaimed Asphalt Pavement (RAP) Blends

open access: yesJournal of Engineering and Sustainable Development, 2014
The technique of cold recycling of asphalt pavement materials for road construction is widely used in the world. Different types of locally available stabilizing additives and/or agents were used to find the most suitable one from the point of view of
Mithaq Albeer Louis   +2 more
doaj  

Controlled Atom Transfer Radical Depolymerization

open access: yesAdvanced Science, EarlyView.
Controlled atom transfer radical depolymerization allows for precise, uniform shortening of polymer chains to yield monomers on demand. By tuning catalyst concentration and temperature, this strategy prioritizes deactivation to maintain molecular weight control throughout depolymerization.
Dimitra Mantzara   +4 more
wiley   +1 more source

Neonatal Sevoflurane Exposure Induces Long‐Term Cognitive Impairment via Epigenetically Mediated MMP9 Activation and Perineuronal Net Disruption in the Hippocampal CA2

open access: yesAdvanced Science, EarlyView.
Hippocampal CA2 perineuronal nets ensheathing excitatory pyramidal neurons are selectively vulnerable to repeated neonatal sevoflurane exposure. Epigenetic upregulation of MMP9 via reduced H3K27me3 disrupts PNN integrity, impairs BDNF–TrkB signaling, and causes synaptic protein loss and dendritic spine deficits, leading to persistent social and spatial
Lirong Liang   +11 more
wiley   +1 more source

Cryo‐EM and NMR Reveal a Membrane‐Gated Doc2B–Munc13‐1 Complex and a Helical Doc2B‐SNARE‐Binding Interface

open access: yesAdvanced Science, EarlyView.
Biophysical studies of Doc2B yield a cryo‐electron microscopy structure of its complex with the synaptic vesicle priming factor Munc13‐1 and its binding site to the SNARE complex that mediates synaptic vesicle fusion. These and other results suggest a novel model whereby Doc2 proteins regulate neurotransmitter release through sequential interactions ...
Cyrus T. Rastegar   +8 more
wiley   +1 more source

Cold seeps: climate relevance and anthropogenic impacts

open access: yesFrontiers in Marine Science
Cold seeps are deep-sea benthic features which emit hydrocarbon-rich fluids (primarily methane), representing notable conduits for carbon from long-term geologic stores to the hydrosphere.
Daniel M. Labbé   +5 more
doaj   +1 more source

Near‐Unity Photothermal Conversion in Bimetallic M44 and M81 Nanoclusters Enables NIR‐Driven Photo‐Thermo‐Electricity Generation

open access: yesAdvanced Science, EarlyView.
Atomically precise nanoclusters of Au/Ag alloys are explored as high‐performance photothermal materials, delivering record‐high photothermal efficiencies (up to 91%). Photo‐thermo‐electricity is further demonstrated by integrating nanocluster films with thermoelectric devices.
Avirup Sardar   +7 more
wiley   +1 more source

Decoding Biomolecular Phase Separation: From Physiological Roles to Pathological Mechanisms and Therapeutic Biomaterials Design

open access: yesAdvanced Science, EarlyView.
This review systematically elaborates on the mechanisms underlying physiological regulation and pathological dysregulation of biomolecular phase separation. It also summarizes advances in phase‑separation‑targeted therapeutic strategies and the design of functional biomaterials inspired by this process.
Jiawei Zhu   +5 more
wiley   +1 more source

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