NuSAP Safeguards Centriole Integrity to Mediate CEP57‐CEP152 Torus Recruitment for Proper Engagement
Advanced Science, EarlyView.This study reveals a novel role for the microtubule stabilizer NuSAP at centrioles. NuSAP depletion destabilizes the centriole's tubulin structure, causing premature disengagement, PCM defects, and mis‐localization of the CEP57‐CEP63‐CEP152 complex. By reinforcing centriole architecture, NuSAP enables early CEP57 loading and initiates a newly proposed ...
Shiyu Zhang +8 more
wiley +1 more source
Advanced Science, EarlyView.This work introduces an open‐source all‐optical platform for functional phenotyping of human stem cell‐derived neurons. The system integrates optogenetics, calcium imaging, automated acquisition, and analysis to resolve single‐cell and network activity, enabling longitudinal measurements, disease modeling, and pharmacological screening in preclinical ...
Wardiya Afshar‐Saber +12 more
wiley +1 more source
HeliyonThis study utilized FLUENT dynamic mesh simulation technology to simulate the temperature field distribution characteristics during the continuous casting (CC) process of 5 mm thick Zr41.2Ti13.8Cu12.5Ni10.0Be22.5 (Vit1) bulk metallic glass (BMG ...
Erxu Yang, Tao Ding, Tingzhi Ren
doaj +1 more source
Transforming Grain‐Boundary Brittle Precipitates to Ductility Pathways in Complex Concentrated Alloy
Advanced Science, EarlyView.By engineering graded BCC/L12 interfaces, brittle precipitates in a complex concentrated alloy enable sequential deformation, realizing gigapascal strength with >20% elongation to solve the strength‐ductility trade‐off. ABSTRACT Conventional wisdom holds that hard grain‐boundary (GB) precipitates embrittle structural alloys by acting as crack ...
Zhixin Li +14 more
wiley +1 more source
A Machine Learning Approach for Modelling Cold-Rolling Curves for Various Stainless Steels. [PDF]
Materials (Basel), 2023 Contreras-Fortes J +5 more
europepmc +1 more source
Manifested flatness defect prediction in cold rolling of thin strips
, 2014 International audienceFlatness defects in thin strip cold rolling are a consequence of roll thermo-elastic deformation, from which heterogeneous strip plastic deformation results.
Legrand, Nicolas +2 more
core +3 more sources
Thermally Induced Creep and Viscoelastic Behavior of Copper Micropillar Arrays
Advanced Science, EarlyView.Copper micropillar arrays are fabricated by electrodeposition within through‐glass‐via, and their thermally induced time‐dependent deformation is quantified. Nanoindentation creep, EBSD, and TEM reveal a heat‐treatment‐driven transition between grain‐boundary‐mediated deformation and dislocation‐dominated creep, while Kelvin modeling captures ...
Miao Wang +14 more
wiley +1 more source
Design Optimization of Key Structural Parameters for Tension Measuring Rollers in Temper Mill Units
MetalsDuring the temper rolling process, scratch defects on the lower surface of the steel strip caused by the tension measuring roller are a critical issue that affects the resulting product quality.
Ji Zhang +4 more
doaj +1 more source
HUBUNGAN POSTUR KERJA BERDASARKAN METODE REBA DENGAN KELUHAN SISTEM MUSCULOSKELETAL PADA OPERATOR CONTROL ROOM DI DIVISI COLD ROLLING MILL PT. KRAKATAU STEEL (PERSERO) TBK. CILEGON-BANTEN [PDF]
, 2013 THE RELATIONSHIP BETWEEN CONTROL ROOM OPERATOR'S WORK POSTURE BASED ON REBA METHOD AND MUSCULOSKELETAL SYSTEM COMPLAINT IN COLD ROLLING MILL DIVISION OF PT. KRAKATAU STEEL (PERSERO) TBK.
Almaududi, Akhmad Abul A’la
core
PD‐L1‐Binding Antigen Presenters: Redirecting Vaccine‐Induced Antibodies for Cancer Immunotherapy
Advanced Science, EarlyView.The PBAP‐gE complex anchors gE antigen to PD‐L1 on tumor cells. Vaccine‐induced anti‐gE antibodies simultaneously engage FcγRIIIa on NK cells and tumor‐bound PBAP‐gE, triggering NK cell activation and antibody‐dependent cellular cytotoxicity, thereby selectively eliminating PD‐L1–expressing tumor cells.
Huixin Gao +24 more
wiley +1 more source