Results 111 to 120 of about 40,088 (283)

Cuproptosis and Mitophagy Mediated by the THUMPD1/IGF2R‐Dependent Suppression of AKT and Activation of AMPK Signaling Suppress Lung Adenocarcinoma Progression

Advanced Science, EarlyView.
THUMPD1 drives a tumor‐suppressive signaling cascade in lung adenocarcinoma by promoting IGF2R expression. IGF2R associates with PPP2R1A to suppress AKT and activate AMPK, leading to SLC31A1 upregulation and copper accumulation. Elevated copper disrupts mitochondrial metabolism and induces excessive mitophagy, thereby restraining tumor growth and ...
Kai Wu, Bo Qin, Zhuoyu Gu, Weizheng Ding, Xiaoming Chen, Kaishang Zhang, Yujin Qiao, Shuang Yuan, Song Zhao, Xiangnan Li, Peng Zhang   +10 more
wiley   +1 more source

Cold Stratification of Salvia azurea var. grandiflora Benth. (Lamiaceae) seeds to Break Dormancy

Seed dormancy and its maintenance rely on a range of environmental signals and cues such as light, temperature, soil pH, and moisture. A significant contributor to the cycle of dormancy and germination is temperature. Salvia azurea var. grandiflora Benth.
Coplen, Samantha
core  

Effects of cold-stratification, gibberellic acid and potassium nitrate on seed germination of yellow gentian (Gentiana lutea L.)

, 2016
The purpose of this study was to show the effect of cold-stratification, gibberellic acid and potassium nitrate on seed germination of yellow gentian (Gentiana lutea L.).
Rysha, Agim, Millaku, Fadil, Krasniqi, Elez, Osmani, Mirsade, Mata, Valbona, Abdullai, Kasamedin, Aliu, Sali, Gashi, Bekim   +7 more
core   +1 more source

An Integrated NLP‐ML Framework for Property Prediction and Design of Steels

Advanced Science, EarlyView.
This study presents a data‐driven framework that uses language‐processing techniques to interpret steel processing descriptions and machine‐learning models to predict mechanical properties. By organising complex process histories into meaningful groups and enabling rapid property forecasts, the work supports faster, more informed steel design through ...
Kiran Devraju, Adithya Umanath Rai, Jose Thomson, Marzie Ghorbani, Shujing Zhao, Nick Birbilis   +5 more
wiley   +1 more source

Assessing Natural Seed Dormancy Loss in Alkali Bulrush (Bolboschoenus maritimus): Duck Ingestion and Natural Cold Stratification

, 2017
Waterfowl have been shown to be important dispersers of different species of aquatic plants and the ingestion of seeds by waterfowl can affect seed dormancy loss.
Mossman, Bret
core  

The effects of cold stratification on germination dynamics of loropetalum chinense var. Rubrum yieh

Loropetalum chinense taxon has a great commercial value worldwide. It also stands out with its aesthetic value, flowering characteristics and use in landscape applications. The natural distribution of these types of plants, which have important landscape
Oğuztürk, Türker
core   +1 more source

Pharmacologic Modulation of ARID3A with Rimegepant Reactivates Type I Interferon Signaling and Sensitizes Triple‐Negative Breast Cancer to PD‐1 Blockade

Advanced Science, EarlyView.
This study identifies ARID3A as a key immunosuppressive transcription factor in TNBC. Its inhibition activates the type I IFN pathway, boosting CD8+ T cell infiltration and sensitizing tumors to anti‐PD‐1. The FDA‐approved migraine drug Rimegepant targets ARID3A, enhances immunotherapy efficacy in preclinical models, and establishes a druggable axis to
Teng Zhou, Yifei Zhu, Cheng Zeng, Jinlu Han, Huiying Huang, Doudou Li, Mingxi Lin, Yizi Jin, Qin Guo, Yuxin Yan, Xinhui Mao, Yifei Zhou, Jian Zhang   +12 more
wiley   +1 more source

Tumor‐Derived Exosomes Deliver Membrane‐Bound Fgl2 to Activate FcγRIIB‐Mediated Immunosuppression in Myeloid‐Derived Suppressor Cells

Advanced Science, EarlyView.
This study reveals that the Fgl2‐FcγRIIB signaling axis is a key mechanism by which MDSCs mediate tumor immune evasion. Tumor‐derived exosomes systemically activate MDSCs via this pathway, positioning this axis as a promising broad‐spectrum target for cancer immunotherapy.
Fenglin Lin, Dingqin Cai, Chunli Jian, Yaxian Qi, Linpeng Zheng, Qiao Yang, Longyao Zhang, Diangang Chen, Lingchen Li, Ping Cai, Lingyou Sun, Luping Zhang, Jianguo Sun   +12 more
wiley   +1 more source

Advancing grape breeding through an in vitro embryo germination technique without cold stratification

Horticultural Plant Journal
In grape breeding programs, the extensive planting of seedlings is a crucial aspect. However, grape seeds display distinct dormancy traits, necessitating a prolonged cold stratification process for dormancy release.
Zhenhua Liu, Jing Song, Yan Wang, Ailing Yan, Xiaoyue Wang, Huiling Wang, Jiancheng Ren, Haiying Xu, Pingyin Guan, Lei Sun   +9 more
doaj   +1 more source

The effects of different warm stratification periods on the seed germination of some Rosa taxa

, 2011
In this study, the effects of different warm stratification periods on the seed germination of some Rosa species such as Rosa heckellana ssp. vanheurckiana, Rosa canina, Rosa pulverelanta and Rosa dumalis naturally grown in the Van region were ...
Çelik, F, Türkoglu, N, Karagöz, S, Alp, S   +3 more
core   +1 more source