Results 131 to 140 of about 40,088 (283)

Harnessing MDM2‐Mediated Targeted Degradation of Transcriptional and Epigenetic Machinery to Disrupt Oncogenic Addictions in Pediatric Sarcoma

Advanced Science, EarlyView.
MDM2 dependency in pediatric sarcomas is driven by a novel p53‐independent oncogenic cistrome alongside canonical p53 pathway suppression. This study introduces MDM2‐recruiting transcriptional and epigenetic machinery degraders (MDM2‐TEMADs) as a novel precision oncology modality.
Jiawei Zhou, Xian Guan, Nan Li, Ying Zhang, Long Xie, Xingze Huang, Zhipeng Zhu, Zhuolin Ren, Xiaoyan Yu, Hanjun Guo, Yuanfang Wu, Lin Ma, Suya Zheng, Jingyao Zhang, Jiyang Liu, Victor Kuanmin Lee, Wenhao Chen, H. Phillip Koeffler, Jinhu Wang, Xin Han, Ye Chen, Liang Xu   +21 more
wiley   +1 more source

Cold stratification, temperature, light, GA₃, and KNO₃ effects on seed germination of Primula beesiana from Yunnan, China. [PDF]

Plant Divers, 2020
Yang LE, Peng DL, Li ZM, Huang L, Yang J, Sun H.   +5 more
europepmc   +1 more source

Dark conditioning, cold stratification and a smoke-derived compound enhance the germination of Eucomis autumnalis subsp. autumnalis seeds

, 2006
Seed germination requirements are important for the conservation and propagation of Eucomis autumnalis subsp. autumnalis, a threatened, yet widely utilized medicinal plant in southern Africa.
Sparg, S.G., van Staden, J., Kulkarni, M.G.   +2 more
core   +1 more source

NQO1‐Mediated Anoikis Resistance and Immune Evasion Define a High‐Risk Multi‐Omic Subtype for Precision Management of T1 High‐Grade Bladder Cancer

Advanced Science, EarlyView.
Multi‐omic profiling of T1 high‐grade bladder cancer identifies a high‐risk subtype (T1HG1) driven by NQO1, which couples anoikis resistance with immune evasion. NQO1 orchestrates macrophage–T cell crosstalk suppression via CXCL9 modulation. Pharmacological NQO1 inhibition with skullcapflavone II enhances cisplatin efficacy, representing a promising ...
Bin Guo, Chunru Xu, Shufan Fu, Qiang Cheng, Juan Li, Linkuo Shang, Gaojie Li, Yang Yang, Ying Wang, Yanqing Gong, Shengwei Xiong, Jian Fan, Changwei Yuan, Mei Zhang, Yifan Zuo, Elena Papaleo, Yue Shi, Yuan Liang, Xuesong Li, Hongzhao Li, Weimin Ci   +20 more
wiley   +1 more source

The study of cold leg thermal stratification in APEX-CE

This research presents an analysis of thermal stratification in the reactor cold leg of the Advanced Plant Experiment-Combustion Engineering (APEX-CE).
Antoine, Stephanie Y. L. Antoine
core  

Seeds of Thalictrum mirabile (Ranunculaceae) require cold stratification for loss of nondeep simple morphophysiological dormancy

, 2000
Seeds of the eastern North American herbaceous polycarpic perennial Thalictrum mirabile Small have differentiated but underdeveloped (small) embryos that are physiologically dormant at maturity in September. Physiological dormancy was broken effectively
Jerry M Baskin, Jeffrey L Walck, Carol C Baskin   +2 more
core   +1 more source

Tumor‐Intrinsic ARHGEF3 Enhances Antitumor Immunity by Promoting T‐Cell Infiltration and Limiting Myeloid Cell‐Mediated Immunosuppression

Advanced Science, EarlyView.
ARHGEF3 is broadly downregulated across human cancers and correlates with patient prognosis. Tumor‐intrinsic ARHGEF3 activates the RHOA–ROCK–PTEN cascade to inhibit AKT signaling, thereby promoting chemokine‐driven T‐cell infiltration and relieving lipid‐mediated myeloid immunosuppression.
Yue Li, Lan Wang, Zihao Zhang, Chunmei Qian, Ning Li, Wei Huang, Qian Ba, Xiaojian Liu, Mayu Sun   +8 more
wiley   +1 more source

Stratification of Bitterbrush Seeds

, 1976
The influence of temperature and moisture availability during stratification on the subsequent germination of bitterbrush (Purshia tridentata) seeds was investigated. The threshold for adequate stratification temperatures was abrupt. Temperatures above 5
Evans, R. A., Young, J. A.
core   +1 more source

Multi‐Omics Insights Into the Mechanisms of Early Muscle Fiber Difference and Transformation Between Lean‐Type and Chinese Indigenous Pigs

Advanced Science, EarlyView.
Multi‐omics analyses uncover breed‐specific cis‐regulatory landscapes and higher‐order chromatin architectural differences that underlie early postnatal muscle fiber divergence in pigs. A super‐enhancer upstream of PPP3CB recruits MEF2C to activate PPP3CB transcription, while the PPP3CB–MEF2C positive feedback loop promotes oxidative muscle fiber ...
Shuailong Zheng, Hainan Wu, Min Liu, Kunpeng Wu, Shuntao Huang, Zulfiqar Ahmed, Lenox Pius, Mengjin Zhu, Dequan Xu   +8 more
wiley   +1 more source

temporal variation of the thermal stratification in the cold leg during emergency core cooling injection

, 2018
International audienceThe aging of the reactor pressure vessel (RPV) can be a limiting factor in life time extension of pressurized water reactors. Important thermal stresses can be generated in the RPV in the case of loss of coolant accidents.
Rodio, Mg., Ulrich Bieder, Bieder, U., Maria Giovanna Rodio   +3 more
core   +1 more source