Results 41 to 50 of about 1,014,034 (345)
β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1
Molecular Oncology, EarlyView.Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero +8 more
wiley +1 more source
Molecular Oncology, EarlyView.A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath +13 more
wiley +1 more source
GERMAN DEMOCRATIC REPUBLIC ESPIONAGE IN SCHLESWIG-HOLSTEIN [PDF]
Romanian Intelligence Studies ReviewThe network of intelligence positions of the HV A in Schleswig- Holstein did not emerge overnight, but was rather the product of a long development process.
Helmut MÜLLER-ENBERGS
doaj
“Battleground Africa: Cold War in the Congo, 1960–1965 (Book Review)” by Lise Namikas [PDF]
, 2016 Review of Battleground Africa: Cold War in the Congo, 1960–1965 by Lise ...
Bertosa, Brian
core +1 more source
Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids
Molecular Oncology, EarlyView.This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici +8 more
wiley +1 more source
Molecular Oncology, EarlyView.Following high dose rate brachytherapy (HDR‐BT) for hepatocellular carcinoma (HCC), patients were classified as responders and nonresponders. Post‐therapy serum induced increased BrdU incorporation and Cyclin E expression of Huh7 and HepG2 cells in nonresponders, but decreased levels in responders.
Lukas Salvermoser +14 more
wiley +1 more source
The terms “Cold War” and “Second Cold War” in the light of contemporary socio-humanities: an encyclopedic perspective [PDF]
Енциклопедичний Вісник УкраїниThis article explores the evolving meanings of the terms "Cold War" and "Second/New Cold War" within contemporary socio-humanities.
Oleksii Yas
doaj +1 more source
A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression
Molecular Oncology, EarlyView.Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak +8 more
wiley +1 more source
United States–Pakistan Relations in Post-Cold War Era: A Political–Security Perspective
The Journal of Indian and Asian Studies, 2020 In this article, the political–security relations between the United States and Pakistan in the Post-Cold War era are analyzed. The allied relationship between the two countries during the Cold War was abruptly disrupted following the conclusion of the ...
KHANH VAN NGUYEN
doaj +1 more source
Molecular Oncology, EarlyView.Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié +16 more
wiley +1 more source