FEBS Letters, EarlyView.Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes +4 more
wiley +1 more source
Mutually assured construction : resurrecting the West Texas missile silos [PDF]
, 2016 A group of enthusiasts near Abilene, Texas are turning decommissioned, Cold War-era nuclear missile silos into homes, doomsday shelters, historical monuments and businesses, offering a unique glimpse into the blue-collar, do-it-yourself psyche of a ...
East, Andrew Joseph
core +1 more source
Aggressive prostate cancer is associated with pericyte dysfunction
Molecular Oncology, EarlyView.Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero +11 more
wiley +1 more source
GERMAN DEMOCRATIC REPUBLIC ESPIONAGE IN SCHLESWIG-HOLSTEIN [PDF]
Romanian Intelligence Studies ReviewThe network of intelligence positions of the HV A in Schleswig- Holstein did not emerge overnight, but was rather the product of a long development process.
Helmut MÜLLER-ENBERGS
doaj
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
The terms “Cold War” and “Second Cold War” in the light of contemporary socio-humanities: an encyclopedic perspective [PDF]
Енциклопедичний Вісник УкраїниThis article explores the evolving meanings of the terms "Cold War" and "Second/New Cold War" within contemporary socio-humanities.
Oleksii Yas
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“Battleground Africa: Cold War in the Congo, 1960–1965 (Book Review)” by Lise Namikas [PDF]
, 2016 Review of Battleground Africa: Cold War in the Congo, 1960–1965 by Lise ...
Bertosa, Brian
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Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
Cold War History beyond the Cold War Discourse: A Conversation with Łukasz Stanek
Architectural Histories, 2019 This interview engages with Łukasz Stanek in a conversation that contextualizes the Special Collection in Architectural Histories on Marxism and architectural theory across the East-West divide.
Hilde Heynen, Sebastiaan Loosen
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Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source