Results 61 to 70 of about 3,064,809 (249)

LOOKING BACK AT THE COLD WAR AND P-3C ANTI-SUBMARINE WARFARE (ASW) 40 YEARS AGO [PDF]

Defence Science Review, 2017
While many have already forgotten the tense times of the Cold War, it is increasingly important to relook at those events to provide context and references as we engage in increasingly tense relationships with Russia and China. During the 44 years of the
Don Stanton
doaj   +1 more source

Reprogramming tumor cells with LCOR mRNA nanotherapy to enhance immunotherapy

Molecular Oncology, EarlyView.
LCOR (Ligand‐dependent corepressor) mRNA encapsulated in polymeric nanoparticles restores LCOR activity in tumor cells, constraining aggressive tumor cell states and increasing tumor immunogenicity. This reprogramming makes tumor cells more vulnerable to T‐cell attack and enhances their response to immune‐checkpoint immunotherapy.
Gabriel Serra‐Mir, Elena Haro‐Martínez, Sandra Blasco‐Benito, Chiara Cannatà, José Ángel Palomeque, Anna López‐Plana, Maria Sanz‐Flores, Marc Sabartés, Cristina Fornaguera, Toni Celià‐Terrassa   +9 more
wiley   +1 more source

The multifaceted roles of lysosomes in cancer

Molecular Oncology, EarlyView.
Lysosomes support cancer cell adaptation by integrating macromolecule degradation and nutrient recycling with nutrient sensing, inter‐organelle communication and immune regulation. These interconnected functions can promote tumour growth, stress tolerance and therapy resistance, while also creating context‐dependent vulnerabilities that may be ...
Jia Li, Kevin M. Ryan
wiley   +1 more source

United States–Pakistan Relations in Post-Cold War Era: A Political–Security Perspective

The Journal of Indian and Asian Studies, 2020
In this article, the political–security relations between the United States and Pakistan in the Post-Cold War era are analyzed. The allied relationship between the two countries during the Cold War was abruptly disrupted following the conclusion of the ...
KHANH VAN NGUYEN
doaj   +1 more source

USP7 inhibits FOXO1 activity in chronic lymphocytic leukaemia cells enhancing cell survival

Molecular Oncology, EarlyView.
CLL cells rely on BCR‐mediated signalling for survival and proliferation in part through suppression of FOXO1. FOXO1 activity is regulated by a plethora of post‐translational modifications including phosphorylation and ubiquitination. We demonstrated that dual inhibition of BCR signalling and the deubiquitinase USP7 activates FOXO1, modulating its ...
Hassan N.B. Almuhanna, Jodie Hay, Michael W. Moles, Lucy Clarke, Jennifer Cassels, Alison Sefcick, Alison M. McCaig, Heather G. Jørgensen, Alison M. Michie   +8 more
wiley   +1 more source

THE RADICALIZATION OF THE WEST AND THE CLASH OF WORLD ORDERS An interview with RICHARD SAKWA, Professor of Russian and European politics at the University of Kent (Great Britain)

RUDN Journal of Political Science, 2018
The interview with Richars Sakwa has been held in dramatic days when the New Cold war became an evident reality and the British-Russian crisis provoked the fall of diplomacy between Russia and vast majority of the western countries.
Richard Sakwa, Daria Borisovna Kazarinova   +1 more
doaj   +1 more source

Anti-Communism in Britain During the Early Cold War

, 2023
The Cold War produced in many countries a form of political repression and societal paranoia which often infected governmental and civic institutions. In the West, the driving catalyst for the phenomenon was anti-communism. While much has been written on
Gerth, Matthew
core   +1 more source

Overcoming platinum resistance by the disulfiram metabolite CuET in novel preclinical models of human carcinomas

Molecular Oncology, EarlyView.
Cisplatin‐resistant cancer cells survive DNA‐damaging platinum‐based treatment yet remain sensitive to CuET‐induced proteotoxic stress. The distinct mechanism of action allows CuET to overcome and eliminate cisplatin‐resistant tumour cells, unless highly expressed metallothioneins (MTs) interfere with CuET, thereby highlighting MT levels as candidate ...
Stefanos Arampatzis, Tereza Buchtová, Jirina Bartkova, Marie Lund Bay, Christoffer Lynge Halvorsen, Zuzana Machacova, Zdenek Skrott, Martin Mistrik, Ekaterina Dulina, Miguel Andujar‐Sanchez, Estrid Høgdall, Tine Henrichsen Schnack, Claus Høgdall, Berit Jul Mosgaard, Marie Boennelycke, Jacob Brink Laursen, Allan Jensen, Susanne K. Kjær, Tuula Kallunki, Robert Strauss, Jiri Bartek   +20 more
wiley   +1 more source

Hyperactive ice‐binding proteins stabilize cell membranes and improve resistance to dehydration stress in Caenorhabditis elegans

FEBS Open Bio, EarlyView.
TisIBP8, a fungal‐derived hyperactive ice‐binding protein, helps Caenorhabditis elegans survive dehydration. It localizes near cell membranes, reduces cell damage, and helps maintain membrane structure during drying. These results suggest that ice‐binding proteins can protect cells from dehydration stress as well as freezing stress.
Daiki Shimose, Kotaro Ozaki, Ryohei Kuriyama, Yuka Ikemoto, Kazuhiro Mio, Yuji C. Sasaki, Tatsuya Arai, Sakae Tsuda, Yoichi Shinkai, Masahiro Kuramochi   +9 more
wiley   +1 more source

A Study on the Development of European Integration Process Based on Political and Economic Factors Caused by the Cold War [PDF]

SHS Web of Conferences
European integration began due to the influence of the Cold War. Due to the turbulent international situation in recent years, there have been disputes among the people of various European countries regarding European integration and its development ...
Wan Di Man
doaj   +1 more source