Results 61 to 70 of about 43,879 (263)

Cold War historiography at the crossroads [PDF]

open access: yesCold War History, 2014
How is the Cold War understood in an expanding and diversifying historiographical field? Conceptual precision and specificity seem to be giving way to a looser understanding of the Cold War as an era that encompassed different although interconnected conflicts and transformations.
openaire   +3 more sources

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

open access: yesMolecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen   +11 more
wiley   +1 more source

THE RADICALIZATION OF THE WEST AND THE CLASH OF WORLD ORDERS An interview with RICHARD SAKWA, Professor of Russian and European politics at the University of Kent (Great Britain)

open access: yesRUDN Journal of Political Science, 2018
The interview with Richars Sakwa has been held in dramatic days when the New Cold war became an evident reality and the British-Russian crisis provoked the fall of diplomacy between Russia and vast majority of the western countries.
Richard Sakwa   +1 more
doaj   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

open access: yesMolecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau   +36 more
wiley   +1 more source

“I don’t believe in seeking distance from your own time”. A talk with Odd Arne Westad about the limits of the Cold War and the challenges of Popular History

open access: yesPráticas da História, 2017
Odd Arne Westad is a historian whose work largely focuses on the Cold War as well as on Chinese and East Asian history. He is best known as a key voice of ‘new Cold War history’, an expanding field which, since the turn of the century, has sought ...
Rui Lopes
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

open access: yesMolecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla   +9 more
wiley   +1 more source

Reconsidering Development Aid: A Systemic Analysis

open access: yesWorld Review of Political Economy, 2020
In the political and academic debates on development aid in the post-Cold War years, there is often reference to a “new aid architecture.” This study explores what is new about this “new architecture of aid” and traces change and continuity by comparing ...
Yahya Gülseven
doaj   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

open access: yesMolecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova   +14 more
wiley   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

open access: yesMolecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan   +16 more
wiley   +1 more source

Die Koue Oorlog: Die Wêreld se Langste Oorlog? / The Cold War: The World's Longest War?

open access: yesScientia Militaria, 2012
The Cold War is a war that was never declared and never terminated. Historians differ rather seriously on when, how and where it began. They do not, however, differ on the fact that it simply faded away at the end of the eighties, but they assign ...
P.H. Kapp
doaj   +1 more source

Home - About - Disclaimer - Privacy