Results 51 to 60 of about 3,193,783 (382)

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Cold War History beyond the Cold War Discourse: A Conversation with Łukasz Stanek

Architectural Histories, 2019
This interview engages with Łukasz Stanek in a conversation that contextualizes the Special Collection in Architectural Histories on Marxism and architectural theory across the East-West divide.
Hilde Heynen, Sebastiaan Loosen
doaj   +1 more source

United States–Pakistan Relations in Post-Cold War Era: A Political–Security Perspective

The Journal of Indian and Asian Studies, 2020
In this article, the political–security relations between the United States and Pakistan in the Post-Cold War era are analyzed. The allied relationship between the two countries during the Cold War was abruptly disrupted following the conclusion of the ...
KHANH VAN NGUYEN
doaj   +1 more source

Features of the "Monumental" Policy of the United States in Relation to the Conflicts of the Cold War (on the Example of Monuments in Washington, D.C.)

Известия Алтайского государственного университета, 2023
In this article, the authors analyze the unique features of the United States' "monumental" policy in relation to the conflicts of the Cold War and the associated memorial and commemorative spaces within the metropolitan region. Specifically, the authors
Влада Евгеньевна Дергачева, Юрий Георгиевич Чернышов   +1 more
doaj   +1 more source

Cold War Anthropology

, 2016
In Cold War Anthropology , David H. Price offers a provocative account of the profound influence that the American security state has had on the field of anthropology since the Second World War.
D. Price
semanticscholar   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

HAS THE PERIOD OF 'CIVILIAN POWER EUROPE' COME TO AN END?

Ankara Avrupa Çalışmaları Dergisi, 2002
During the Cold War, to the extent that it performed at the international stage, the European Community was portrayed as a ‘civilian power’, because it lacked the relevant military instruments and relied on ‘economic and diplomatic means’ to try to ...
Sinem Akgül Açıkmeşe
doaj   +1 more source

Decolonization and the Cold War

Journal of Global Strategic Studies, 2023
Throughout the Cold War era, the United States and the Soviet Union frequently faced the dilemma of whether to recognize or to confer legitimacy upon armed insurgencies vying to overturn established civil authority.
Robert McMahon
doaj   +1 more source

Glycosylated LGALS3BP is highly secreted by bladder cancer cells and represents a novel urinary disease biomarker

Molecular Oncology, EarlyView.
Urinary LGALS3BP is elevated in bladder cancer patients compared to healthy controls as detected by the 1959 antibody–based ELISA. The antibody shows enhanced reactivity to the high‐mannose glycosylated variant secreted by cancer cells treated with kifunensine (KIF).
Asia Pece, Giulio Lovato, Ilaria Cela, Arianna Mercatelli, Benedetta Ferro, Jussi Nikkola, Sara Pagotto, Tommaso Grottola, Vincenzo De Laurenzi, Rossella Cicchetti, Antonio Marchetti, Luigi Schips, Rossano Lattanzio, Stefano Iacobelli, Emily Capone, Peter Black, Mads Daugaard, Michele Marchioni, Gianluca Sala   +18 more
wiley   +1 more source