Results 61 to 70 of about 977,695 (302)

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

A Study on the Development of European Integration Process Based on Political and Economic Factors Caused by the Cold War [PDF]

SHS Web of Conferences
European integration began due to the influence of the Cold War. Due to the turbulent international situation in recent years, there have been disputes among the people of various European countries regarding European integration and its development ...
Wan Di Man
doaj   +1 more source

"It sure as hell looked like war": terrorism and the Cold War in Thomas Pynchon's Against the Day and Don DeLillo's Underworld [PDF]

, 2013
This piece explores, necessarily briefly, the conceptions of terrorism in two novels that stand separated by the calamitous events of September 11th, 2001: Pynchon's Against the Day and Don DeLillo's Underworld, with special focus upon the genesis of ...
Eve, Martin Paul
core   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

“I don’t believe in seeking distance from your own time”. A talk with Odd Arne Westad about the limits of the Cold War and the challenges of Popular History

Práticas da História, 2017
Odd Arne Westad is a historian whose work largely focuses on the Cold War as well as on Chinese and East Asian history. He is best known as a key voice of ‘new Cold War history’, an expanding field which, since the turn of the century, has sought ...
Rui Lopes
doaj   +1 more source

Multilateral security in the Mediterranean post-Cold War: NATO’s Mediterranean Dialogue and the EuroMed Partnership. Jean Monnet/Robert Schuman Paper Series Vol. 7 No. 10 May 2007 [PDF]

, 2007
[From the introduction]. In this paper I will compare and contrast how the multilateral efforts in terms of NATO’s Mediterranean Dialogue (“Dialogue”) program, involving i.a. U.S.
Boening, Astrid B.
core  

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Reconsidering Development Aid: A Systemic Analysis

World Review of Political Economy, 2020
In the political and academic debates on development aid in the post-Cold War years, there is often reference to a “new aid architecture.” This study explores what is new about this “new architecture of aid” and traces change and continuity by comparing ...
Yahya Gülseven
doaj   +1 more source

'Behind Enemy Lines' Menzies, Evatt and Passports for Peking [PDF]

, 2003
This article focuses primarily on Australian government responses to the 1952 Peace Conference for Asia and the Pacific Regions. Because the conference was to be held in Peking, it was the subject of immense controversy: Chinese communists were fighting
Goddard, Steve, Vuran, Mehmet C, Wang, Yunbo   +2 more
core   +2 more sources

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source