Results 191 to 200 of about 461,819 (327)

Recent Utilization of Pediatric Extrapolation and Modeling and Simulation Approaches in Pediatric Drug Development in Japan

The Journal of Clinical Pharmacology, EarlyView.
Abstract In Japan, the percentage of approved drugs with pediatric indications increased to 30% in 2010‐2015, but no further increase was observed through 2020. The Ministry of Health, Labor, and Welfare in Japan presented draft future directions to promote pediatric drug development, where the modeling and simulation (M&S) approach was introduced as a
Akinori Nakashima, Akihide Tsujimoto, Masako Saito, Jun Takeda, Makiko Natori, Satoshi Shoji   +5 more
wiley   +1 more source

Accuracy of Bowel Ultrasound for Detecting Inflammatory Bowel Disease at a Tertiary Hospital in Central South Africa

Journal of Clinical Ultrasound, EarlyView.
Bowel wall thickness, as measured by bowel ultrasound, demonstrates high diagnostic accuracy in evaluating patients with suspected inflammatory bowel disease (IBD). When combined with other bowel ultrasound parameters, this non‐invasive tool can serve as an effective screening method to accelerate IBD diagnosis.
Amanda Hendricks, Henra Muller
wiley   +1 more source

Plasma interleukin-22 concentration and disease activity in inflammatory bowel disease. [PDF]

Sci Rep
Cabrera C, Fernández-Llaneza D, Olsson M, Sopp C, Fehlmann T, Duncan EA, Khan E, Cairns J, Neisen J, Gehrmann U, Powell N.   +10 more
europepmc   +1 more source

A Comprehensive Review of Food-Derived Compounds Targeting Pyroptosis for Colitis Therapy: From Effects to Mechanisms. [PDF]

J Inflamm Res
Zhao JW, Li LY, Ye FW, Zhao WY.
europepmc   +1 more source

Point‐Counterpoint: Adult patients in children's hospitals

Journal of Hospital Medicine, EarlyView.
Abstract Adults continue to be admitted to children's hospitals for a variety of reasons. But should they? Transfer from the pediatric to adult hospital setting is the standard of high‐quality care for any young adult. Adult hospitalists are equipped to care for these patients.
Meg Groom, Ruchi Doshi, Rachel Peterson, Ashley Jenkins   +3 more
wiley   +1 more source

Mechanisms of NLRP3 inflammasome in pathogenesis and progression of inflammation-related gastrointestinal diseases. [PDF]

PeerJ
Liu F, Shao B, Zhu Y, Xue X, Wu X.
europepmc   +1 more source

Specific phenotypes may drive an increased incidence of pediatric inflammatory bowel disease in South‐Eastern Norway

Journal of Pediatric Gastroenterology and Nutrition, EarlyView.
Abstract Objectives Pediatric inflammatory bowel disease (PIBD) incidence has increased in recent decades but may be stabilizing, prompting exploration of incidence changes, disease distribution, and severity. Methods From 2017 to 2019, patients under 18 years with PIBD symptoms were recruited from nine hospitals in South‐Eastern Norway for ...
Svend Andersen, Tomm Bernklev, Ketil Størdal, Milada C. Hagen, Vendel A. Kristensen, Randi Opheim, Christine Olbjørn, Jon Rove, Emma E. Løvlund, Hans K. Holm, Batool Aballi, Marte L. Høivik, Gøri Perminow   +12 more
wiley   +1 more source

The association between 4-HPR-mediated LCN2 suppression and reduced intestinal cell senescence in ulcerative colitis. [PDF]

Clin Exp Med
Pan X, Wang J, Zhu J, Wang X, Liu Y, Chen S, Wang P.   +6 more
europepmc   +1 more source

North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition position paper on the therapeutic drug monitoring in pediatric inflammatory bowel disease

Journal of Pediatric Gastroenterology and Nutrition, EarlyView.
Abstract Inflammatory bowel diseases (IBD) require effective therapies to prevent morbidity and maintain quality of life. The introduction of biologic agents, beginning with monoclonal antibodies targeting tumor necrosis factor (TNF) alpha, has launched a new era of advancements that have markedly improved short‐ and long‐term outcomes of Crohn's ...
Lina M. Felipez, Sabina Ali, Edwin F. de Zoeten, Anne M. Griffiths, Sandra C. Kim, Ashish S. Patel, Joel R. Rosh, Jeremy Adler   +7 more
wiley   +1 more source

Potential miRNAs as Diagnostic Biomarkers for Differentiating Disease States in Ulcerative Colitis: A Systematic Review. [PDF]

Int J Mol Sci
Khan AU, Chacon-Millan P, Stiuso P.
europepmc   +1 more source