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Nature Reviews Disease Primers, 2020
Ulcerative colitis (UC) is a chronic inflammatory bowel disease of unknown aetiology affecting the colon and rectum. Multiple factors, such as genetic background, environmental and luminal factors, and mucosal immune dysregulation, have been suggested to contribute to UC pathogenesis.
Silvio Danese +2 more
exaly +8 more sources
Ulcerative colitis (UC) is a chronic inflammatory bowel disease of unknown aetiology affecting the colon and rectum. Multiple factors, such as genetic background, environmental and luminal factors, and mucosal immune dysregulation, have been suggested to contribute to UC pathogenesis.
Silvio Danese +2 more
exaly +8 more sources
Lancet, The, 2017 Ulcerative colitis is a chronic inflammatory disease affecting the colon, and its incidence is rising worldwide. The pathogenesis is multifactorial, involving genetic predisposition, epithelial barrier defects, dysregulated immune responses, and environmental factors.
Jean-Frédéric Colombel +2 more
exaly +3 more sources
The Lancet, 2002
Ulcerative colitis is a chronic inflammatory disease of the rectum and colon. Results from many studies in people and animals of intestinal inflammation suggest that ulcerative colitis results from environmental factors triggering a loss of tolerance for normal intestinal flora in genetically susceptible individuals.
Richard J, Farrell, Mark A, Peppercorn
openaire +3 more sources
Ulcerative colitis is a chronic inflammatory disease of the rectum and colon. Results from many studies in people and animals of intestinal inflammation suggest that ulcerative colitis results from environmental factors triggering a loss of tolerance for normal intestinal flora in genetically susceptible individuals.
Richard J, Farrell, Mark A, Peppercorn
openaire +3 more sources
Lancet, The, 2023
Ulcerative colitis is a lifelong inflammatory disease affecting the rectum and colon to a variable extent. In 2023, the prevalence of ulcerative colitis was estimated to be 5 million cases around the world, and the incidence is increasing worldwide. Ulcerative colitis is thought to occur in people with a genetic predisposition following environmental ...
Sailish Honap +2 more
exaly +4 more sources
Ulcerative colitis is a lifelong inflammatory disease affecting the rectum and colon to a variable extent. In 2023, the prevalence of ulcerative colitis was estimated to be 5 million cases around the world, and the incidence is increasing worldwide. Ulcerative colitis is thought to occur in people with a genetic predisposition following environmental ...
Sailish Honap +2 more
exaly +4 more sources
Hospital Medicine, 2000
Ulcerative colitis is a relatively common cause of altered bowel habit and rectal bleeding. Coordinated management of the investigation and care of patients with this condition is vital to optimize treatment. This article reviews current management options.
M, Miller, A, Windsor
openaire +2 more sources
Ulcerative colitis is a relatively common cause of altered bowel habit and rectal bleeding. Coordinated management of the investigation and care of patients with this condition is vital to optimize treatment. This article reviews current management options.
M, Miller, A, Windsor
openaire +2 more sources
Surgical Clinics of North America
Ulcerative colitis (UC) is a type of inflammatory bowel disease that can be managed medically with steroids, immunomodulators, biologics, and advanced therapies. Dysplasia screening is important in patients with longstanding disease owing to the significantly increased risk of malignancy. Surgery is indicated for medically refractory disease, dysplasia,
Samara, Spence, Karen, Zaghiyan
openaire +2 more sources
Ulcerative colitis (UC) is a type of inflammatory bowel disease that can be managed medically with steroids, immunomodulators, biologics, and advanced therapies. Dysplasia screening is important in patients with longstanding disease owing to the significantly increased risk of malignancy. Surgery is indicated for medically refractory disease, dysplasia,
Samara, Spence, Karen, Zaghiyan
openaire +2 more sources
Ulcerative Colitis: Pathogenesis
Current Drug Targets, 2011The pathogenesis of ulcerative is still poorly understood. With the introduction of new culture-independent techniques the research on the intestinal microbiota has revealed an important reduction of Bacteroidetes and Firmicutes leading to a reduced biodiversity and dysbiosis in these patients.
FRIES, Walter, S. Comunale
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