Results 221 to 230 of about 672,024 (402)

Machine learning identifies a distinct microbiota signature in immune checkpoint inhibitor colitis compared with inflammatory bowel disease. [PDF]

open access: yesOncologist
Barberio B   +17 more
europepmc   +1 more source

Association Between Microscopic Colitis and Parkinson's Disease in a Swedish Population

open access: hybrid, 2021
Xiaoying Kang   +7 more
openalex   +1 more source

Isoform Specificity of a Compound Targeting Actin Filaments Containing Tropomyosin Tpm1.8/1.9

open access: yesCytoskeleton, EarlyView.
ABSTRACT The unbranched actin filaments in mammalian cells are usually composed of co‐polymers of a specific tropomyosin isoform with actin. Genetic manipulation has revealed that the tropomyosins largely define the functional properties of actin filaments in an isoform‐specific, non‐redundant manner.
Jeff Hook   +2 more
wiley   +1 more source

Model‐Informed Deep Q‐Networks to Guide Infliximab Dosing in Pediatric Crohn’s Disease

open access: yesClinical Pharmacology &Therapeutics, EarlyView.
Model‐informed precision dosing (MIPD) utilizes pharmacokinetic/pharmacodynamic (PK/PD) models to optimize drug therapy. However, conventional MIPD often requires manual simulation and regimen selection, which are time‐consuming and demand specialized expertise.
Kei Irie   +6 more
wiley   +1 more source

Vedolizumab as induction and maintenance therapy for ulcerative colitis.

open access: yesNew England Journal of Medicine, 2013
B. Feagan   +15 more
semanticscholar   +1 more source

Pathway‐Informed Machine Learning Identifies Genetic Predictors of High‐Dose Methotrexate‐Induced Mucositis in Pediatric Acute Lymphoblastic Leukemia

open access: yesClinical Pharmacology &Therapeutics, EarlyView.
High‐dose methotrexate for pediatric cancer treatment is frequently associated with mucositis, which can lead to delayed or discontinued treatment and impact survival. While individual genetic variants have been implicated, the cumulative impact of genetic variation within relevant biological pathways remains unexplored.
Xiao Yu Cindy Zhang   +9 more
wiley   +1 more source

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