Results 81 to 90 of about 4,372,185 (277)

The cooperative regulation of miR‐221 by APE1 and AUF1 impacts p27Kip1 defining a miR signature relevant for cervical cancer

FEBS Open Bio, EarlyView.
A regulatory axis involving APE1, AUF1, and miR‐221 is proposed. Pri‐miR‐221 is processed by DROSHA and DICER to generate mature miR‐221, which targets p27Kip1 mRNA. APE1 and AUF1 compete for pre‐miR‐221 binding. Reduced APE1/AUF1 levels impair miR‐221 biogenesis, decrease p27Kip1 mRNA degradation, and promote cell cycle progression, chemoresistance ...
Matilde Clarissa Malfatti, Nicolò Gualandi, Gianluca Tell, Giulia Antoniali   +3 more
wiley   +1 more source

“After a long day of play, I get tired and forget to unfurl my bed net”: a qualitative study exploring factors affecting insecticide-treated bed net use among school-aged children in eastern Uganda

Malaria Journal
Background Despite widespread access to long-lasting insecticidal nets, infection with malaria parasites remains prevalent among African school-aged children.
Deborah Ekusai Sebatta, Sarah Alexander, John Rek, Maato Zedi, Emmanuel Arinaitwe, Mallory O. Johnson, Joaniter I. Nankabirwa, Moses R. Kamya, Grant Dorsey, Paul J. Krezanoski   +9 more
doaj   +1 more source

An overview of osteopathy graduates’ perceived preparedness at transition from educational environment to clinic environment one year after graduation: a cross sectional study

BMC Medical Education, 2018
Background This study investigated perceived preparedness to practice, one year after graduation across osteopathic education institutions (OEIs) and explored possible differences between countries where osteopathy is regulated (Reg) and countries where ...
E. Luciani, G. Consorti, P. L. S. van Dun, O. Merdy, C. Lunghi, M. Petracca, J. E. Esteves, F. Cerritelli   +7 more
doaj   +1 more source

Open Charm Production at HERA

, 2001
Measurements of charmed particle cross sections at HERA in the photoproduction and deep inelastic regimes are reviewed. The status of the comparison with perturbative QCD calculations is discussed.Comment: Presented at the Ringberg Workshop on ``New ...
Adloff C (H1 Collaboration), Adloff C (H1 Collaboration), Berezhnoy A V, Breitweg J (ZEUS Collaboration), Breitweg J (ZEUS Collaboration), Breitweg J (ZEUS Collaboration), Breitweg J (ZEUS Collaboration), Breitweg J (ZEUS Collaboration), Breitweg J (ZEUS Collaboration), Chekanov S (ZEUS Collaboration), Chekanov S (ZEUS Collaboration), Frixione S, Gladilin L, Ignacio Redondo, Jung H, Mohrdieck S (H1 Collaboration)   +15 more
core   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

The Uganda housing modification study - association between housing characteristics and malaria burden in a moderate to high transmission setting in Uganda

Malaria Journal
Background Scale up of proven malaria control interventions has not been sufficient to control malaria in Uganda, emphasizing the need to explore innovative new approaches. Improved housing is one such promising strategy.
Joaniter I. Nankabirwa, Samuel Gonahasa, Agaba Katureebe, Peter Mutungi, Martha Nassali, Moses R. Kamya, Nelli Westercamp   +6 more
doaj   +1 more source

Variations of high frequency parameter of heart rate variability following osteopathic manipulative treatment in healthy subjects compared to control group and sham therapy: randomized controlled trial

Frontiers in Neuroscience, 2015
Context: Heart Rate Variability (HRV) indicates how heart rate changes in response to inner and external stimuli. HRV is linked to health status and it is an indirect marker of the autonomic nervous system (ANS) function.
Nuria eRuffini, Giandomenico eD'alessandro, Nicolò eMariani, Alberto ePollastrelli, Lucia eCardinali, Francesco eCerritelli   +5 more
doaj   +1 more source

Jet production at HERA I

, 2003
This article reviews recent jet physics results from ...
Caron, Sascha, H1 Collaboration, ZEUS Collaboration   +2 more
core   +1 more source

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

FEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke, Michal Banasik, Rokas Juodeikis, Martin J. Warren, Richard W. Pickersgill   +4 more
wiley   +1 more source

Mid-level managers’ perspectives on implementing isoniazid preventive therapy for people living with HIV in Ugandan health districts: a qualitative study

BMC Health Services Research
Background Isoniazid preventive therapy (IPT) works to prevent tuberculosis (TB) among people living with HIV (PLHIV), but uptake remains low in Sub-Saharan Africa.
Canice Christian, Elijah Kakande, Violah Nahurira, Cecilia Akatukwasa, Fredrick Atwine, Robert Bakanoma, Harriet Itiakorit, Asiphas Owaraganise, William DiIeso, Derek Rast, Jane Kabami, Jason Johnson Peretz, Starley B. Shade, Moses R. Kamya, Diane V. Havlir, Gabriel Chamie, Carol S. Camlin   +16 more
doaj   +1 more source