Results 81 to 90 of about 1,627,654 (309)
BuildingsWith the increasing awareness of architectural heritage conservation and the development of digital technology, there is an urgent need in the field of architectural heritage restoration for a novel solution that can enhance data security, collaboration ...
Cong Zhou +5 more
doaj +1 more source
Solid Fuel Orbiter Designe in Optimized Space Transfer [PDF]
فصلنامه علوم و فناوری فضایی, 2015 The design method presented in this paper is for utilizing, fast and easy system designing of orbital transfer block for transferring satellite from park orbit to destination orbit.
Mehran Nosrat Elahi +2 more
doaj
Journal of Interactive Media in Education, 2013 Online learning environments offer new opportunities for learning and over the last decade or so a variety of online learning environments have been developed by researchers to facilitate collaborative learning among students. In this paper we will present a case study of a successful collaborative learning design.
Blake, Canan, Scanlon, Eileen
openaire +4 more sources
The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes
FEBS Letters, EarlyView.Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga +3 more
wiley +1 more source
Molecular Oncology, EarlyView.EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain +10 more
wiley +1 more source
Sketch-Based Interfaces to Support Collaborative Conceptual Design Learning [PDF]
, 2007 In order to gain a better understanding of online collaborative conceptual design processes this paper investigates how student designers make use of Lyceum, a shared virtual synchronous environment when engaged in conceptual design. The software enables
Aczel, James +3 more
core
Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source
Molecular cancer prevention: Intercepting disease
Molecular Oncology, EarlyView.Oncological practice must evolve, from treating established tumours to proactive cancer interception before clinical manifestation. This will require mechanistic insight into tumour initiation, validated biomarkers of early disease development and redesigned clinical trials, enabling cancer interception to become a core pillar of oncology with the ...
Charlotte Grieco +2 more
wiley +1 more source
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Observing network characteristics in mass collaboration design projects
Design Science, 2018 Mass collaboration efforts can increase innovation and design possibilities. Incorporation of open innovation into the product development process allows for a vast array of unique perspectives and ideas.
Zachary Ball, Kemper Lewis
doaj +1 more source