Results 61 to 70 of about 480,019 (268)

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Antipsychotic Treatment Failure: A Systematic Review on Risk Factors and Interventions for Treatment Adherence in Psychosis

Frontiers in Neuroscience, 2020
Objective: Antipsychotic medication non-adherence has detrimental effects on patients' clinical outcome. It is unclear which risk factors affect adherence most and which interventions are effective at improving adherence to antipsychotic medication.
Kawtar El Abdellati, Kawtar El Abdellati, Livia De Picker, Livia De Picker, Manuel Morrens, Manuel Morrens   +5 more
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Strategy and Impact of Liner Shipping Schedule Recovery under ECA Regulation and Disruptive Events

Journal of Marine Science and Engineering
In the post-pandemic era, the complexity of the international shipping situation, such as environmental policies, port congestion, and local conflicts, poses challenges to the stability of liner shipping, which requires strict adherence to schedules ...
Jingmiao Zhou, Yuzhe Zhao, Xinran Yan, Meican Wang   +3 more
doaj   +1 more source

Valuation Studies: A Collaborative Valuation in Practice

Valuation Studies, 2014
This discussion note provides a perspective on valuation studies by a group of PhD students. Based on impressions from the Valuation as Practice workshop at The University of Edinburgh in early 2014 we were inspired by the example of Kjellberg et al ...
Gordon Haywood, Johan Nilsson, Michael Franklin, Paul Gilbert, Linus Johansson Krafve, Lisa Lindén, Mark MacGillivray, Robert Meckin   +7 more
doaj   +1 more source

Harmonization of Collaborative Study Protocols

Journal of AOAC INTERNATIONAL, 1986
Abstract The 2 major protocols for the design, conduct, and interpretation of collaborative analytical studies—those from AOAC and the International Organization for Standardization—are already fairly well harmonized. The statistical models are identical and the outlier tests are essentially the same. The major differences are in symbols
openaire   +2 more sources

Introducing Collaborative Practices to Undergraduate Studies [PDF]

, 2016
The changes in software industry and software development methods call for appropriate teaching methods in academia. In addition to theoretical knowledge and coding practice, familiarity with common practices in the industry is expected from the graduates.
Jaana Holvikivi, Minna Lakkala, Hanni Muukkonen   +2 more
openaire   +2 more sources

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

Latin American Collaborative Study of Congenital Malformations (ECLAMC): A Model for Health Collaborative Studies

Public Health Genomics, 2014
Fil: Castilla, Eduardo Enrique. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. CEMIC-CONICET. Centro de Educaciones Médicas e Investigaciones Clínicas ; Argentina.
Poletta, Fernando Adrián, Gili, Juan Antonio, Castilla, Eduardo Enrique   +2 more
openaire   +3 more sources

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

FEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke, Michal Banasik, Rokas Juodeikis, Martin J. Warren, Richard W. Pickersgill   +4 more
wiley   +1 more source