Results 91 to 100 of about 2,015,033 (345)

Whistleblowing: the inside story - a study of the experiences of 1,000 whistleblowers [PDF]

, 2013
This report presents the findings of a collaborative research project by the University of Greenwich and Public Concern at Work, on how the whistleblowing process develops from internal to external whistleblowing.
James, Cathy, Public Concern at Work, University of Greenwich, Vandekerckhove, Wim, West, Francesca   +4 more
core  

The cooperative regulation of miR‐221 by APE1 and AUF1 impacts p27Kip1 defining a miR signature relevant for cervical cancer

FEBS Open Bio, EarlyView.
A regulatory axis involving APE1, AUF1, and miR‐221 is proposed. Pri‐miR‐221 is processed by DROSHA and DICER to generate mature miR‐221, which targets p27Kip1 mRNA. APE1 and AUF1 compete for pre‐miR‐221 binding. Reduced APE1/AUF1 levels impair miR‐221 biogenesis, decrease p27Kip1 mRNA degradation, and promote cell cycle progression, chemoresistance ...
Matilde Clarissa Malfatti, Nicolò Gualandi, Gianluca Tell, Giulia Antoniali   +3 more
wiley   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

Permanent training for teachers of “Parque Explora” An approach to the learning community Astromae

Senderos Pedagogicos, 2017
The article it is a cuantitative investigation called permanent formation for teachers in different places of the facultates of education a study of case in relation with the Teachers Friends of Explora-Astromae.
Luisa Fernanda Casas Fernández, Juan Pablo Suárez Vallejo   +1 more
doaj   +1 more source

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

FEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

Collaborative Work with Highly Automated Marine Navigation Systems. [PDF]

Comput Support Coop Work, 2022
Veitch E, Dybvik H, Steinert M, Alsos OA.   +3 more
europepmc   +1 more source

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

FEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke, Michal Banasik, Rokas Juodeikis, Martin J. Warren, Richard W. Pickersgill   +4 more
wiley   +1 more source

O espectro do reconhecimento: a trajetória de Vilma Chiara

Journal de la Société des Américanistes
This article seeks to discuss the process of the eclipsing of Vilma Chiara (1927-2020) in the history of Brazilian anthropology. It first proposes an overview of her singular trajectory and, immediately thereafter, an analysis of some of her own ...
Maria Julia Fernandes Vicentin
doaj   +1 more source

Sustainable landscape management based on cultural ecosystem services

Change and Adaptation in Socio-Ecological Systems, 2017
To sustain cultural ecosystem services and cultural heritage it is important to go in depth in the science policy interface, because efficient governance mechanisms emerge from the cooperation of scientists and practitioners.
Palacios-Agundez Igone, Peña Lorena, Ametzaga-Arregi Ibone, Rodríguez-Loinaz Gloria, Onaindia Miren   +4 more
doaj   +1 more source

Prevalence of pesticide related occupational diseases among Indonesian vegetable farmers - A collaborative work. [PDF]

Toxicol Rep, 2023
Febriana SA, Khalidah M, Huda FN, Sutarni S, Mahayana I, Indrastuti N, Setyopranoto I, Waskito F, Prawiroranu S, Dwianingsih EK, Malueka RG.   +10 more
europepmc   +1 more source