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Advanced Science, EarlyView.A new class of biohybrid spheroids is engineered through the self‐assembly of adherent cells and extracellular matrix‐mimetic hydrogel microparticles (microgels). By mimicking a snowballing effect, this approach enables scalable formation of porous, millimeter‐scale spheroids with enhanced cell viability and molecular diffusion.
Zaman Ataie +7 more
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Advanced Science, EarlyView.Antibody–drug conjugates (ADCs) transform breast cancer therapy, yet resistance limits their durability. Emerging evidence reveals that ADC failure is not solely tumor‐intrinsic but shaped by dynamic tumor–microenvironment interactions that alter drug delivery, processing, and response.
Minji Seo, Jangsoon Lee, Naoto T. Ueno
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Advanced Science, EarlyView.DOT1L as a central epigenetic regulator of EndoMT and pulmonary fibrosis. Acting as an early epigenetic switch, it translates TGFβ–SMAD signaling into H3K79me2‐mediated chromatin remodeling, selectively activates fibrosis‐related genes, and primes ECs for rapid mesenchymal transition.
Yaofeng Wang +11 more
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Advanced Science, EarlyView.A healthy gut barrier shields underlying fibroblasts from luminal shear forces, illustrating that “good fences make good neighbors.” Barrier damage exposes fibroblasts to shear stress, inducing cell death and the emergence of stress‐adapted, profibrotic fibroblasts. Sustained shear exposure promotes the formation of stiff aggregates of mechanoadapative
Soyoun Min +6 more
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Comparison of standard versus accelerated corneal collagen cross-linking for keratoconus: 5-year outcomes from the Save Sight Keratoconus Registry. [PDF]
Eye (Lond)Kandel H +7 more
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Corneal Collagen Cross-linking
American Journal of Ophthalmology, 2012Corneal collagen cross-linking has recently emerged as a novel approach for management of ectasia. This article reviews the literature published in the past 3 years about the expanding spectrum of cross-linking as a therapeutic modality and its complications.Recent studies have confirmed the beneficial effects of cross-linking in stabilization and to a
Kunal, Suri +2 more
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Collagen and Related Research, 1982
The structural macromolecules of the extracellular matrix have been investigated with rapidly increasing activity and depth in the past decade. Collagen, and to a lesser extent, elastin, were among the earliest of this group to be studied in more detail than the proteoglycans and adhesive glycoproteins.
M L, Tanzer, J H, Waite
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The structural macromolecules of the extracellular matrix have been investigated with rapidly increasing activity and depth in the past decade. Collagen, and to a lesser extent, elastin, were among the earliest of this group to be studied in more detail than the proteoglycans and adhesive glycoproteins.
M L, Tanzer, J H, Waite
openaire +2 more sources
Corneal Collagen Cross-Linking Complications
Seminars in Ophthalmology, 2017Corneal cross-linking was approved by United States Food and Drug Administration for the treatment of progressive keratoconus in April 2016. As this approach becomes more widely used for the treatment of keratoconus and post-laser in situ keratomileusis (LASIK) ectasia, the medical community is becoming more familiar with potential complications ...
Charisma B, Evangelista +1 more
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