Results 291 to 300 of about 1,359,174 (352)
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Edaravone suppresses degradation of type II collagen
Biochemical and Biophysical Research Communications, 2016Osteoarthritis (OA) is a degenerative joint disease affecting millions of people. The degradation and loss of type II collagen induced by proinflammatory cytokines secreted by chondrocytes, such as factor-α (TNF-α) is an important pathological mechanism to the progression of OA.
Chen, Huang +4 more
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Type II collagen—induced auricular chondritis
Arthritis & Rheumatism, 1982AbstractSensitization to type II collagen induced inflammatory destruction of elastic ear cartilage, as well as arthritis, in Sprague—Dawley rats. This auricular lesion morphologically resembled relapsing polychondritis in humans. Moreover, in the experimental model, as has been reported in human disease, extraarticular chondritis occurred in the ...
W J, McCune +3 more
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Antibodies to Type II Collagen in Relapsing Polychondritis
New England Journal of Medicine, 1978Relapsing polychondritis is a disorder of unknown cause characterized by the destruction of cartilage. To test the hypothesis that immunologic mechanisms are involved in the pathogenesis of relapsing polychondritis, we analyzed the serum of 15 patients for the presence of antibodies to cartilage. Antibodies to Type II (cartilage) collagen were found in
J M, Foidart +6 more
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Fibromodulin Interactions with Type I and II Collagens
Connective Tissue Research, 2007Fibromodulin is a keratan-sulfate small leucine-rich proteoglycan (SLRP) regulating collagen I and II fibril formation. In vivo studies suggest that, alongside decorin, fibromodulin plays an important role in the maintenance of mature tissues. To characterize fibromodulin/decorin differences in binding to type I and II collagen, we tested the collagen ...
VIOLA, MANUELA +5 more
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Type II Collagen Autoimmunity in Rheumatoid Arthritis
The American Journal of the Medical Sciences, 2004This review summarizes the autoimmune reaction to type II collagen (CII) autoimmunity with regard not only to antibody response to CII but also to the clinical significance or biological characteristics of the CII-reactive T cell, focusing on studies of human RA rather than on animal models.
Wan-Uk, Kim +7 more
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Stretching type II collagen with optical tweezers
Journal of Biomechanics, 2004Collagens are the most abundant proteins of vertebrates and they provide mechanical and supportive functions in a wide range of connective tissues. Knowledge of the mechanical properties of single collagen molecules is essential in studying the self-assembly of collagen, the interaction between cells and extracellular matrix, the etiology of tissue ...
Yu-Long, Sun +3 more
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Type II collagen screening in the human chondrodysplasias
American Journal of Medical Genetics, 1989AbstractAbnormalities of type II collagen have been considered strong candidates for causing human chondrody splasias. We have employed peptide mapping to screen for several types of type II collagen abnormalities in cartilage samples from 66 patients with 20 separate disorders. Except for achondrogenesis type II (Langer‐Saldino) and spondyloepiphyseal
W A, Horton +3 more
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Type II collagen autoimmunity and Ménière's disease
The Journal of Laryngology & Otology, 1993AbstractAntibodies to type II collagen have been reported by some authors to be raised in patients with Ménière's disease. In this study the antibody levels to type I and II collagen have been measured in 37 patients with Ménière's disease and 20 controls, using a solid-phase, double-antibody, enzyme-linked, immunoassay.
R C, Herdman +3 more
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Dual Effects of Type II Collagen on the Degradation of Type I Collagen by Tadpole Collagenase
Collagen and Related Research, 1981Kinetic analysis of the degradation of mixtures of type I and type II collagens by tadpole collagenase was performed, using [14C]glycine-labeled type I collagen and [3H]acetylated type II collagen as substrates. The degradation rate of type I collagen was decreased in the initial stage of the reaction, then further slowed down giving a constant rate ...
H, Sunada, T, Hayashi, H, Hori, Y, Nagai
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1993
Changes are confined to tissue sites which contain type II collagen (hyaline cartilage). Peripheral arthropathy is manifest grossly, in the squirrel monkey by acute swelling of the affected finger joints (Cathcart et al. 1986), with most of the swelling subsiding with the passing of the acute phase.
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Changes are confined to tissue sites which contain type II collagen (hyaline cartilage). Peripheral arthropathy is manifest grossly, in the squirrel monkey by acute swelling of the affected finger joints (Cathcart et al. 1986), with most of the swelling subsiding with the passing of the acute phase.
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