Results 241 to 250 of about 8,497,397 (298)

Lilrb4a Suppression Reprograms Microglia to Mitigate APOE4‐Associated Amyloid Plaques and Cerebral Amyloid Angiopathy in Association With a PPAR‐Linked Pro‐Clearance State

Advanced Science, EarlyView.
Targeting Lilrb4a in Apolipoprotein E4 (APOE4)‐associated Alzheimer's disease (AD) reprograms microglia toward a beneficial, phagocytic state. Genetic deletion or antisense inhibition of Lilrb4a suppresses p‐SHP2/NF‐κB/STAT1 signaling, restores PPAR‐linked lipid and energy metabolism, and reduces amyloid plaque burden and cerebral amyloid angiopathy ...
Changxu Nie, Ruixi Yang, Xiaotong Wang, Ping Jia, Xueqi Zhang, Yaqi Dai, Xue Bai, Sijia Duan, Yufeng Li, Peng Zheng, Xin Tian, Li Jiang, Chao Wang   +12 more
wiley   +1 more source

Structural Characterization of Cardiac Free-Running Purkinje Fibers Using Inhomogeneous Magnetization Transfer (ihMT): A Proof of Concept MRI-Histology Approach. [PDF]

NMR Biomed
Forodighasemabadi A, Kornaropoulos EN, Constantin M, Soustelle L, Vaillant F, Leury J, Walton R, Bernus O, Quesson B, Girard OM, Duhamel G, Magat J.   +11 more
europepmc   +1 more source

Optimization of B Cell Responses in Human Immune System Mice Through Organoid Based Screening

Advanced Science, EarlyView.
Human immune system (HIS) mice show limited B cell responses to immunization. Using HIS mouse spleen organoids, this study identifies cytokine combinations and innate immune signals that drive human B cell expansion, differentiation, and class‐switch. Applying these signals in vivo through temporal separation enables antigen‐specific IgG responses and ...
Haiqiao Sun, He Li, Xu Zhu, Zijian Zhang, Deshan Ren, Shuai Ding, Yan Li   +6 more
wiley   +1 more source

Stress cardiomyopathy in vascular Ehlers-Danlos syndrome: first case report and proposed mechanisms. [PDF]

ESC Heart Fail
Che X, Wang Z, Tang X, Zhang C, Wang W, Chen Q, Zhou Y.   +6 more
europepmc   +1 more source

Reticular Basement Membrane Remodelling Regulates Bronchial Epithelial Attachment, Barrier Integrity and Inflammatory Signalling in Asthma. [PDF]

Adv Respir Med
Hsieh A, Barker-Mulleder J, Yang CX, Fouadi M, Hackett TL.   +4 more
europepmc   +1 more source

Myocardial fibrosis and viability: the role of imaging and biomarkers in patients with chronic total occlusion on coronary angiography. [PDF]

Biochem Med (Zagreb)
Dragila Tomašić Ž, Maršić L, Mikolčić A, Maričić L, Selthofer Relatić K, Šnajder Mujkić D.   +5 more
europepmc   +1 more source

Type III collagen : a major fibrillar collagen with major issues

, 2017
openaire   +1 more source

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Distribution of type I collagen in human kidney diseases in comparison with type III collagen

Journal of Pathology, 1990
AbstractThe distribution of type I collagen in normal and diseased renal tissues was studied using immunofluorescence and immunoelectron microscopy, and was compared with that of type III collagen. In normal human kidneys, a monoclonal antibody against type I or type III collagen reacted with the renal interstitium, but not with the intra‐glomerular ...
S Maki, N Akano, A Ooshima
exaly   +3 more sources

Demonstration of type III collagen in the dentin of mice

Matrix Biology, 1992
It has been reported that, although type III collagen is present in human dentin where there is dentinogenesis imperfecta and in reparative dentin, it is absent in normal dentin. In a preliminary study, however, we observed evidence showing that small amounts of fibers showing positive labeling for type III collagen are present in the molars of normal ...
Y Ohsaki, K Kurisu, Kojiro Kurisu
exaly   +3 more sources