Results 111 to 120 of about 916,539 (289)

IL-13 mediates collagen deposition via STAT6 and microRNA-135b: a role for epigenetics [PDF]

, 2016
Systemic sclerosis is an autoimmune connective tissue disease in which T cells play a prominent role. We and others have previously demonstrated a role for T cell-derived IL-13 in mediating the induction of collagen in dermal fibroblasts and that ...
van Laar, Jacob, Van Laar, Jacob M., O'Reilly, Steven, Fullard, Nicola, Ciechomska, Marzena, Przyborski, Stefan, van Laar, J.M., O’Reilly, S., Fullard, N., Przyborski, S., Ciechomska, M.   +10 more
core   +2 more sources

Matrix Stiffness Enhances Odontogenic Differentiation of DPSCs through Membrane Curvature Protein Baiap2‐Modulated Exosome Release

Advanced Science, EarlyView.
Matrix stiffness softening is identified as a previously underappreciated feature in deep caries. Higher stiffness drives exosome release in dental pulp stem cells through a coordinated mechanism involving PI3K–AKT‐regulated Baiap2 and kinesin‐1, thereby promoting odontogenic differentiation.
Bilun Jin, Shaojie Dong, Yue Jia, Zhao Xu, Peiqi Liu, Zhaojing Ding, Yuxin Liao, Rui Zou, Jinsong Hu, Bo Cheng, Lin Niu   +10 more
wiley   +1 more source

EGFR inhibition for metastasized cutaneous squamous cell carcinoma in dystrophic epidermolysis bullosa

Orphanet Journal of Rare Diseases, 2019
Dystrophic epidermolysis bullosa (DEB) is a hereditary skin fragility disorder, characterized by trauma-induced blistering followed by soft tissue fibrosis.
Andrea Diociaiuti, Holger Steinke, Alexander Nyström, Agnes Schwieger-Briel, Frank Meiss, Christina Pfannenberg, Leena Bruckner-Tuderman, Juri Ruf, Rita De Vito, May El Hachem, Dimitra Kiritsi   +10 more
doaj   +1 more source

SLY1 and Syntaxin 18 specify a distinct pathway for procollagen VII export from the endoplasmic reticulum

eLife, 2014
TANGO1 binds and exports Procollagen VII from the endoplasmic reticulum (ER). In this study, we report a connection between the cytoplasmic domain of TANGO1 and SLY1, a protein that is required for membrane fusion.
Cristina Nogueira, Patrik Erlmann, Julien Villeneuve, António JM Santos, Emma Martínez-Alonso, José Ángel Martínez-Menárguez, Vivek Malhotra   +6 more
doaj   +1 more source

Interrogation of RDEB Epidermal Allografts after BMT Reveals Coexpression of Collagen VII and Keratin 15 with Proinflammatory Immune Cells and Fibroblasts. [PDF]

J Invest Dermatol, 2022
Riedl JA, Riddle M, Xia L, Eide C, Boull C, Ebens CL, Tolar J.   +6 more
europepmc   +1 more source

COL7A1 mutation G2037E causes epidermal retention of type VII collagen [PDF]

, 2006
COL7A1 glycine substitution (GS) mutations result in dominant and recessive dystrophic epidermolysis bullosa (DDEB and RDEB). Here, we report a DDEB family in which a female proband showed retention of type VII collagen inepidermal keratinocytes ...
Nakamura, Hideki, Shibata, Satoko, Tashiro, Akari, Sato-Matsumura, Kazuko, Furue, Masutaka, Goto, Maki, Akiyama, Masashi, Sawamura, Daisuke, Shimizu, Hiroshi, Sakai, Kaori   +9 more
core   +1 more source

DDX3x Regulates NINJ1 Transcription via Histone Lactylation in Sepsis Associated‐Acute Kidney Injury

Advanced Science, EarlyView.
This study identifies a potential therapeutic approach for sepsis‐associated acute kidney injury (SA‐AKI). We found that during SA‐AKI, reduced expression of DDX3x in renal tubular epithelial cells mediates histone delactylation, which in turn upregulates NINJ1 transcription and triggers tubular cell death. Conversely, Odetiglucan confers protection by
Hongyu Liang, Jihong Jiang, Huanxin Yin, Chunyan Liu, Hongjun Huang, Yan Luo, Minmin Zhu, Qiuyun Wang   +7 more
wiley   +1 more source

The regulation of type I collagen gene expression in stromal fibroblast by breast tumour cells [PDF]

, 2011
Includes abstract.Includes bibliographical references (leaves 110-135).Recent studies have revealed that interactions between tumour cells and the surrounding stroma play an important role in facilitating tumour growth and invasion.
Rose, Beverley Ann
core   +1 more source

TANGO1 recruits ERGIC membranes to the endoplasmic reticulum for procollagen export

eLife, 2015
Previously we showed that membrane fusion is required for TANGO1-dependent export of procollagen VII from the endoplasmic reticulum (ER) (Nogueira, et al., 2014).
António JM Santos, Ishier Raote, Margherita Scarpa, Nathalie Brouwers, Vivek Malhotra   +4 more
doaj   +1 more source

Type VII Collagen, Anchoring Fibrils, and Epidermolysis Bullosa

Journal of Investigative Dermatology, 1993
The anchoring fibrils at the dermal-epidermal junction have been well characterized as ultrastructural entities. From their appearance, it was proposed that they fortified the attachment of the epidermis to the dermis. This hypothesized function was strengthened by observations indicating that the anchoring fibrils were abnormal, diminished, or absent ...
openaire   +2 more sources