Results 111 to 120 of about 23,288 (156)
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Restoring type VII collagen in skin
Med, 2022New therapeutic hope is emerging for people with the rare inherited blistering skin disease recessive dystrophic epidermolysis bullosa (RDEB). Gurevich et al.1 have reported early-phase clinical trial data evaluating a topical herpes simplex virus 1 vector to restore missing type VII collagen in RDEB skin and heal wounds.
Lwin, Su M., McGrath, John A.
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Molecular biology and pathology of type VII collagen*
Experimental Dermatology, 1992Abstract Type VII collagen is a genetically distinct member of the collagen family of proteins. Type VII collagen has been shown to be the major component of anchoring fibrils, attachment complexes which secure the cutaneous basement membrance of the skin to the underlying dermis. Understanding of the structure of type VII collagen has been advanced by
Jouni Uitto, Angela M Christiano
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High-affinity binding of the NC1 domain of collagen VII to laminin 5 and collagen IV
Biochemical and Biophysical Research Communications, 2006 Anchoring functions of collagen VII depend on its ability to form homotypic fibrils and to bind to other macromolecules to form heterotypic complexes. Biosensor-based binding assays were employed to analyze the kinetics of the NC1 domain-mediated binding of collagen VII to laminin 5, collagen IV, and collagen I.
Jouni Uitto, Andrzej Fertala
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The vWFA2 domain of type VII collagen is responsible for collagen binding
Biochemical and Biophysical Research Communications, 2013Type VII collagen (Col7) is the major component of anchoring fibrils and very important for skin integrity. This is emphasized by the Col7 related skin blistering diseases dystrophic epidermolysis bullosa and epidermolysis bullosa acquisita. Structural data that provides insights into the interaction network of Col7 and thus providing a basis for a ...
Karsten Seeger
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Collagen VII expression in glomerular sclerosis
The Journal of Pathology, 2001Abstract Glomerular sclerosis is the final stage of a variety of kidney diseases and matrix molecules not normally expressed in the extracellular matrix are synthesized and accumulate during the sclerotic process.
Muda AO +4 more
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Collagen VII and Bullous Disorders of the Skin
Dermatology, 2009Recent advances in molecular and cell biology of the cutaneous basement membrane zone have drastically increased our knowledge of the pathomechanisms underlying skin blistering disorders. Defects in genes coding for the structural proteins of the basement membrane zone have been defined in epidermolysis bullosa (EB), and abnormal expression of the ...
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Laminins, tenascin and type VII collagen in colorectal mucosa
The Histochemical Journal, 1996The distribution of different laminin polypeptides, type VII collagen and tenascin has been studied in adult and foetal colorectal mucosa by using the indirect immunofluorescence technique. Immunoreactivity for laminin alpha 1 chain was located to basement membranes of epithelia, muscularis mucosae, and blood vessels, respectively in different segments
J, Lohi +6 more
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COLLAGEN VII EXPRESSION IN HUMAN CHRONIC WOUNDS AND SCARS
The Journal of Pathology, 1997Collagen VII is the major structural component of the anchoring fibrils that stabilize the cutaneous basement membrane on the dermis. Disruption and, more usually, destruction of the basement membrane are characteristic of wounds that are slow, or fail, to heal, such as chronic lower-limb or pressure ulcers.
I, Hopkinson +3 more
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Molecular cloning and characterization of type VII collagen cDNA
Biochemical and Biophysical Research Communications, 1992Type VII collagen, located in human epidermal basement membrane, is the primary pathogenic target molecule in epidermolysis bullosa acquisita and epidermolysis bullosa dystrophica. Using a monoclonal antibody against the non-collagenous domain of type VII collagen, approximately 1 Kb cDNA was isolated from human keratinocyte library.
T, Tanaka +3 more
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Distribution of type-VII collagen in xenografted human carcinomas
Cell & Tissue Research, 1993The distribution of type-VII collagen, the main molecular component of the anchoring fibrils (AF) attaching the basal lamina (BL, lamina densa of the basement membrane) to the surrounding connective tissue, was investigated in four xenografted human carcinomas of the hypopharynx (H-Stg 1), the lung (L 261), the sigmoid colon (CA 1), and the rectum (R ...
P, Köpf-Maier, C, Schröter-Kermani
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