Results 51 to 60 of about 23,288 (156)
Epidermolysis bullosa pruriginosa: A report of two cases
Indian Dermatology Online Journal, 2014 Epidermolysis bullosa (EB) pruriginosa is a very rare pattern of dystrophic EB caused by type VII collagen gene mutation, with distinctive clinico-pathological features. It is characterized by nodular prurigo-like lichenified lesions, nail dystrophy, and
Varadraj Vasant Pai +5 more
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Detection of Type VII collagen in odontogenic keratocyst: An immunohistochemical study
Journal of Clinical and Experimental Dentistry, 2019 Separation of the epithelial lining from the underlying connective tissue wall has been a frequently observed and unique feature in odontogenic keratocysts (OKC), but not in other odontogenic cysts nor neoplasms. No study on OKC has been reported evaluating the role of type VII Collagen, the anchoring fibrils, which function in stabilising the ...
Cota, Jochima-Eudora +2 more
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Cylindroma Overexpresses Collagen VII, the Major Anchoring Fibril Protein
Journal of Investigative Dermatology, 1991 The cell clusters of the human adnexal tumor, cylindroma, are surrounded by an unusual, thick, unorganized basement membrane-like zone in vivo. Ultrastructural analysis of this electron-dense zone revealed recesses that contained numerous anchoring fibrils.
Bruckner-Tuderman L +2 more
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Type VII Collagen, Anchoring Fibrils, and Epidermolysis Bullosa
Journal of Investigative Dermatology, 1993 The anchoring fibrils at the dermal-epidermal junction have been well characterized as ultrastructural entities. From their appearance, it was proposed that they fortified the attachment of the epidermis to the dermis. This hypothesized function was strengthened by observations indicating that the anchoring fibrils were abnormal, diminished, or absent ...
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Inflammation-mediated fibroblast activation and immune dysregulation in collagen VII-deficient skin. [PDF]
Front Immunol, 2023 Anderson-Crannage M +13 more
europepmc +1 more source
Epithelial-Mesenchymal Interactions Enhance Expression of Collagen VII In Vitro
Journal of Investigative Dermatology, 1990 Expression of collagen VII, the major structural protein of the anchoring fibrils, was assessed in vitro using indirect immunofluorescence staining and immunoblotting of collagen VII isolated from cultures. A very low level of expression was observed in monocultures of normal human fibroblasts or keratinocytes, but the expression was greatly stimulated
König A, Bruckner-Tuderman L
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Orphanet Journal of Rare Diseases, 2019 Dystrophic epidermolysis bullosa (DEB) is a hereditary skin fragility disorder, characterized by trauma-induced blistering followed by soft tissue fibrosis.
Andrea Diociaiuti +10 more
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eLife, 2014 TANGO1 binds and exports Procollagen VII from the endoplasmic reticulum (ER). In this study, we report a connection between the cytoplasmic domain of TANGO1 and SLY1, a protein that is required for membrane fusion.
Cristina Nogueira +6 more
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TANGO1 recruits ERGIC membranes to the endoplasmic reticulum for procollagen export
eLife, 2015 Previously we showed that membrane fusion is required for TANGO1-dependent export of procollagen VII from the endoplasmic reticulum (ER) (Nogueira, et al., 2014).
António JM Santos +4 more
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Long Hanging Structure of Collagen VII Connects the Elastic Fibers and the Basement Membrane in Young Skin Tissue. [PDF]
J Histochem Cytochem, 2022 Tohgasaki T +4 more
europepmc +1 more source