Results 101 to 110 of about 12,280 (281)

A universal strategy for high-yield production of soluble and functional clostridial collagenases in E. coli

, 2009
Clostridial collagenases are foe and friend: on the one hand, these enzymes enable host infiltration and colonization by pathogenic clostridia, and on the other hand, they are valuable biotechnological tools due to their capacity to degrade various types
Eckhard, Ulrich, Hans Brandstetter, Gerhard Gottschalk, Esther Schönauer, Nuess, Dorota, Dorota Nüss, Gottschalk, Gerhard, Ulrich Eckhard, Ducka, Paulina, Kofler, Stefan, Schoenauer, Esther, Brandstetter, Hans, Paulina Ducka, Stefan Kofler   +13 more
core   +1 more source

ERK‐Mediated Phosphorylation of YAP Defines a Noncanonical FGF Signaling Mechanism in Stem Cells

Advanced Science, EarlyView.
With a powerful combination of in vivo, ex vivo, and in vitro models, the authors highlight a novel FGF‐ERK signaling regulation of YAP at the S128 site in neural crest‐derived stem cells. This study opens exciting new directions in stem cell biology and craniofacial biology, paving the way for potential innovations in the treatment of craniofacial ...
Xiaolei Zhao, Shannon Erhardt, Li Tang, Xiaotong Chen, Stephen M Farmer, Zixiu Cheng, Wen Chen, Ella Ziyuan Lu, Kihan Sung, Chang‐Ru Tsai, Mingjie Zheng, Sheng Zhang, Yang Liu, Jianxin Wang, Min Li, James F Martin, Jun Wang   +16 more
wiley   +1 more source

Physicochemical Properties of a Bioactive Polysaccharide Film from Cassia grandis with Immobilized Collagenase from Streptomyces parvulus (DPUA/1573)

Cosmetics
(1) Background: Polysaccharide films are promising vehicles for the delivery of bioactive agents such as collagenases, as they provide controlled release at the wound site, facilitating tissue regeneration.
Kétura Ferreira, Kethylen Cardoso, Romero Brandão-Costa, Joana T. Martins, Cláudia Botelho, Anna Neves, Thiago Nascimento, Juanize Batista, Éverton Ferreira, Fernando Damasceno, Amanda Sales-Conniff, Wendell Albuquerque, Ana Porto, José Teixeira   +13 more
doaj   +1 more source

CONTRIBUTION IN THE SYNTHESIS OF PSEUDOPEPTIDES. APPLICATIONS TO INHIBITORS OF MAMMALIAN COLLAGENASES

, 1994
ΣΤΗΝ ΕΡΓΑΣΙΑ ΑΥΤΗ ΠΑΡΟΥΣΙΑΖΟΝΤΑΙ ΨΕΥΔΟΠΕΠΤΙΔΙΑ ΣΑΝ ΑΝΑΣΤΟΛΕΙΣ ΤΗΣ ΚΟΛΛΑΓΕΝΑΣΗΣ ΑΠΟ ΒΔΕΛΛΑ ΕΝΑ ΕΝΖΥΜΟ ΠΟΥ ΣΥΜΠΕΡΙΦΕΡΕΤΑΙ ΟΠΩΣ ΟΙ ΚΟΛΛΑΓΕΝΑΣΕΣ ΤΩΝ ΘΗΛΑΣΤΙΚΩΝ.ΟΙ ΚΟΛΛΑΓΕΝΑΣΕΣ ΠΟΥ ΕΧΟΥΝ ZN ΣΤΟ ΕΝΕΡΓΟ ΤΟΥΣ ΚΕΝΤΡΟ ΑΝΑΣΤΕΛΛΟΝΤΑΙ ΑΠΟ ΠΕΠΤΙΔΙΚΑ ΑΝΑΛΟΓΑ ΠΟΥ ...
Tzovaras, Dimitrios, Τζοβάρας, Δημήτριος   +1 more
core   +1 more source

Paternal Circadian Disruption Impairs Offspring Cognition via Sperm microRNAs

Advanced Science, EarlyView.
Paternal circadian disruption remodels the sperm small RNA payload, elevating miR‐92a‐3p/miR‐25‐3p levels and perturbing early embryonic gene regulatory programs. Microinjection experiments and single‐embryo transcriptomics reveal sex‐specific developmental vulnerabilities, ultimately impairing offspring hippocampal synaptic plasticity and cognition ...
Kexin Zou, Sisi Luo, Binliang Tang, Zhiqiang Liu, Yuchuan Zhou, Yicong Meng, Zhengmu Wu, Zheng Sun, Weihui Shi, Jianzhong Sheng, Chuanjin Yu, Zhenhua Li, Siyi Wei, Mo Zhang, Yujie Luo, Jing Yan, Xueyun Qin, Jiahang Mo, Chengliang Zhou, Jinsong Li, Hefeng Huang, Yifu Ding, Guolian Ding   +22 more
wiley   +1 more source

Bacterial Collagenase [PDF]

Journal of Bacteriology, 1945
openaire   +3 more sources

Unbalanced collagenases/TIMP-1 expression and epithelial apoptosis in experimental lung fibrosis

, 2003
In this study, we examined the sequential expression of several matrix metalloproteinases ( MMPs), tissue inhibitors of metalloproteinases (TIMPs), and growth factors as well as the presence of apoptosis in a model of pulmonary fibrosis induced in rats ...
Ramirez, R, Uhal, B, Becerril, C, Ordonez, RM, Berumen, J, Selman, M, Ruiz, V, Pardo-Cemo, Annie   +7 more
core   +1 more source

Gut Mycobiota‐Associated Tryptophan Catabolites Protect Against Metabolic Dysfunction‐Associated Steatotic Liver Disease

Advanced Science, EarlyView.
ABSTRACT Accumulating evidence suggests that the intestinal microbiota participates in the progression of metabolic dysfunction‐associated steatotic liver disease (MASLD) through microbiota‐host interaction. However, the beneficial role of commensal mycobiota in MASLD progression remains poorly understood.
Shuping Qiao, Shuangya Fan, Juan Xu, Zhen Xu, Chen Peng, Junxing Qu, Ziqian Bing, Shizhen Zhou, Sunan Shen, Guifang Xu, Yue Zhao, Tingting Wang   +11 more
wiley   +1 more source

Mechanostimulatory Cues Determine Intestinal Fibroblast Fate and Profibrotic Remodeling in a Physiodynamic Human Gut‐on‐a‐Chip

Advanced Science, EarlyView.
A healthy gut barrier shields underlying fibroblasts from luminal shear forces, illustrating that “good fences make good neighbors.” Barrier damage exposes fibroblasts to shear stress, inducing cell death and the emergence of stress‐adapted, profibrotic fibroblasts. Sustained shear exposure promotes the formation of stiff aggregates of mechanoadapative
Soyoun Min, Nam Than, Yong Cheol Shin, Elif G. Ertugral, Chandrasekhar R. Kothapalli, Olumuyiwa Awoniyi, Hyun Jung Kim   +6 more
wiley   +1 more source

Ultrasound quantitative characterization of tendinopathy with shear wave elastography in an ex vivo porcine tendon model

European Radiology Experimental
Background Early detection and treatment of tendinopathy may prevent progression to partial tears or complete rupture. Shear wave elastography (SWE) may help address the need for better tendon pathology characterization.
Quinn Steiner, Albert Wang, Laura Slane, Scott Hetzel, Ryan DeWall, Darryl Thelen, Kenneth Lee   +6 more
doaj   +1 more source