Results 111 to 120 of about 12,280 (281)

Enhanced cleavage of type II collagen by collagenases in osteoarthritic articular cartilage

, 1997
Billinghurst RC, Dahlberg L, Ionescu M, et al. Enhanced cleavage of type II collagen by collagenases in osteoarthritic articular cartilage. JOURNAL OF CLINICAL INVESTIGATION.
Billinghurst, RC, Hambor, J, Tschesche, Harald, A Reiner, A R Poole, Poole, AR, Ionescu, M, Dahlberg, L, L Dahlberg, Chen, J, R Bourne, Diekmann, O, VanWart, H, Reiner, A, J Hambor, J Chen, Mitchell, P, C Rorabeck, R C Billinghurst, O Diekmann, H Tschesche, Bourne, R, P Mitchell, H Van Wart, M Ionescu, Rorabeck, C   +25 more
core   +1 more source

Targeting Peptostreptococcus anaerobius with an Iron‐Based Nanozyme Reverses Ferroptosis Resistance and Enhances Antitumor Immunity in Colorectal Cancer

Advanced Science, EarlyView.
An iron‐based nanozyme selectively eliminates intratumoral P. anaerobius while catalytically generating ROS to induce ferroptosis, synergistically suppressing colorectal cancer growth and activating anti‐tumor immunity through immunogenic cell death. ABSTRACT The intratumoral microbiota is a critical determinant of therapeutic outcomes in colorectal ...
Yinghao Cao, Jun Wang, Hanwenchen Wang, Xiang Sun, Fang Fang, Shiying Li, Jianping Liu, Changrong Shi, Pengyuan Qi, Jianhua Zou, Xiaoyuan Chen, Kailin Cai   +11 more
wiley   +1 more source

Agnuside Stabilizes the Complex I Assembly Factor NDUFAF6 to Reinforce Mitochondrial Efficiency and Thermogenic Responsiveness

Advanced Science, EarlyView.
ABSTRACT Brown and beige adipocytes dissipate energy as heat, yet effective strategies to enhance their mitochondrial efficiency remain limited. Here, we identify Agnuside (AGN) as a selective stabilizer of the complex I assembly factor NDUFAF6. AGN directly binds cytosolic NDUFAF6, suppresses its ubiquitination, prolongs its half‐life, and facilitates
Qingwen Zhao, Li Xie, Qianzhuo Wang, Shuying Dai, Bei Li, Yingjuan Zhang, Zhe Sun, Yue Gao   +7 more
wiley   +1 more source

PRMT1‐Mediated LDHA Methylation Drives STAT3 Lactylation to Orchestrate Intestinal Inflammation and Tumorigenesis

Advanced Science, EarlyView.
This study identifies an immunometabolic axis wherein SAM‐driven PRMT1 methylates LDHA, enhancing its activity. The resultant lactate induces STAT3 K709 lactylation, which stabilizes an active conformation to promote STAT3 phosphorylation and IL‐10 expression.
Hui Wang, Mengyu Zhang, Weipeng Gong, Jiaxuan Wu, Junping Zhang, Wenxiu Zhang, Yue Liu, Kui Wang, Canhua Huang, Jun Zhou, Sijin Wu, Yan Li, Tianliang Li   +12 more
wiley   +1 more source

STRUCTURAL IMPLICATIONS FOR THE ROLE OF THE N-TERMINUS IN THE SUPERACTIVATION OF COLLAGENASES - A CRYSTALLOGRAPHIC STUDY

, 1994
REINEMER P, GRAMS F, HUBER R, et al. STRUCTURAL IMPLICATIONS FOR THE ROLE OF THE N-TERMINUS IN THE SUPERACTIVATION OF COLLAGENASES - A CRYSTALLOGRAPHIC STUDY. FEBS LETTERS.
Piper, Michael, Tschesche, Harald, HUBER, R, Huber, Robert, Harald Tschesche, Schnierer, Susanne, Kleine, Thomas, Thomas Kleine, SCHNIERER, S, Robert Huber, Michael Piper, Reinemer, Peter, Frank Grams, PIPER, M, Wolfram Bode, KLEINE, T, Grams, Frank, GRAMS, F, Susanne Schnierer, Bode, Wolfram, BODE, W, Peter Reinemer, REINEMER, P   +22 more
core   +1 more source

RNA Helicase DDX21 Controls CD4+ T Cell Proliferation and Promotes Inflammatory Bowel Disease via Translational Control

Advanced Science, EarlyView.
ABSTRACT Inflammatory bowel disease (IBD) is characterized by dysregulated T cell responses. RNA helicases, including DExD‐box helicase 21 (DDX21), are pivotal in RNA metabolism, but their role in T cell‐mediated pathology during IBD remains unclear. Here, we demonstrate that DDX21 expression in CD4+ T cells correlates with cell cycle and translation ...
Yujuan Zhang, Chen Kan, Xinhui Yang, Yajuan Hao, Xuemin Cai, Mei Yang, Qianqian Zhang, Zhengting Wang, Ning Jiang, Lei Wang, Hua‐Bing Li, Jing Zhou   +11 more
wiley   +1 more source

Concerns for Collagenase [PDF]

The Journal of Hand Surgery, 2016
openaire   +2 more sources

Production of marine microbial collagenases in cultured plant cells

The fishing and seafood industries play a key role in the Portuguese economy. However, the by products of these industries are currently discarded, despite their high potential for the production of valuable compounds due to their high collagen content ...
Santos, Sofia Rebelo Azevedo dos
core  

PET Imaging of Cardiac Inflammation in Viral Myocarditis Using a DPP4‐Targeted Probe

Advanced Science, EarlyView.
This study describes a DPP4‐targeted PET probe for imaging myocardial inflammation by selectively targeting activated immune cells. Derived from the clinically approved small‐molecule inhibitor linagliptin, the probe demonstrates favorable biodistribution with specific cardiac uptake in myocarditis.
Wanhao Gao, Wenzhu Hu, Du Tang, Xinxin Liu, Kun Yu, Lixia Feng, Minyu Liao, Wang Lin, Wenqiang Zhu, Sanjay Rajagopalan, Xiaoli Lan, Jixin Zhong, Dao Wen Wang, Dawei Jiang, Xiaoquan Rao   +14 more
wiley   +1 more source

Polycystic kidney disease-like domains of clostridial collagenases and their role in collagen recruitment

, 2011
Bacterial collagenases exhibit a multimodular domain organization. While the N-terminal collagenase unit harbors the catalytic zinc and suffices to degrade peptidic substrates, collagen substrates come in different types, explaining the requirement for ...
Hans Brandstetter, Ulrich Eckhard, Brandstetter, H., Eckhard, U.   +3 more
core   +1 more source