Results 31 to 40 of about 308,890 (241)

Postpartum collapse

Obstetric Medicine, 2019
Abrupt deterioration in the mother’s condition may occur postpartum as a result of a broad array of conditions, many of them rare. Maternal survival depends on aggressive resuscitation, rapid precise diagnosis and the institution of disease-targeted therapy. Additionally there may be implications for any future pregnancy.
openaire   +4 more sources

Collapsing bacterial cylinders [PDF]

Physical Review E, 2001
Under special conditions bacteria excrete an attractant and aggregate. The high density regions initially collapse into cylindrical structures, which subsequently destabilize and break up into spherical aggregates. This paper presents a theoretical description of the process, from the structure of the collapsing cylinder to the spacing of the final ...
Betterton, M. D., Brenner, Michael P.
openaire   +3 more sources

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

A study of the risk ranking method of landslides and collapses

Shuiwen dizhi gongcheng dizhi, 2021
Geological disasters in China are characterized by multi-point and wide-range distribution, while the manpower and ability of geological disaster risk management and control are relatively limited.
Mingli XIE, Nengpan JU, Yunkun LIU, Xiuwei LIU, Weihua ZHAO, Chengqiang ZHANG   +5 more
doaj   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

Research on Structural Collapse of a Containership under Combined Bending–Torsion by Oblique Waves

Journal of Marine Science and Engineering
Large waves cause a great number of collapsed-ship accidents, resulting in the loss of many lives and properties. It has been found that most of these collapses are caused by encountering oblique waves.
Weiqin Liu, Qilu Zou, Yaqiang Zhang, Yong Nie, Xuemin Song   +4 more
doaj   +1 more source

Knots in Collapsible and Non-Collapsible Balls [PDF]

The Electronic Journal of Combinatorics, 2013
We construct the first explicit example of a simplicial 3-ball $B_{15,66}$ that is not collapsible. It has only 15 vertices. We exhibit a second 3-ball $B_{12,38}$ with 12 vertices that is collapsible and not shellable, but evasive. Finally, we present the first explicit triangulation of a 3-sphere $S_{18, 125}$ (with only 18 vertices) that is not ...
Benedetti, Bruno, Lutz, Frank H.
openaire   +3 more sources

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gabor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source