Results 61 to 70 of about 513,590 (314)

Postintubation Hypotension and its Association with Prolonged ICU Length of Stay and ICU Mortality

open access: yesEgyptian Journal of Critical Care Medicine, 2020
Introduction Cardiovascular collapse (CVC) is a serious complication of endotracheal intubation (ETI). Many studies have evaluated incidence and risk factors for postintubation hypotension.
Amr Mohamed Elsharkawy   +2 more
doaj   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

open access: yesMolecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu   +10 more
wiley   +1 more source

Collapse and Reorganization in Social-Ecological Systems: Questions, Some Ideas, and Policy Implications

open access: yesEcology and Society, 2006
We tested the explanatory usefulness and policy relevance of Holling's (2001) "adaptive cycle" theory in exploring processes of "collapse," also called "release," and recovery in regional social-ecological systems (SESs) in Zimbabwe and Australia.
Nick Abel   +2 more
doaj   +1 more source

Collapse models [PDF]

open access: yes, 2008
40 pages, to be published in "Open Systems and Measurement in Relativistic Quantum Theory," F. Petruccione and H. P. Breuer eds. (Springer Verlag, 1999)
openaire   +2 more sources

Collapse of rockfill

open access: yesInternational Journal of Rock Mechanics and Mining Sciences & Geomechanics Abstracts, 1991
Os materiais de enrocamento exibem deformações devidas à molhagem ou saturação. Nesta comunicação são apresentados resultados de enrocamentos de baixa e elevada resistência ensaiados em cmaras de compressão unidimensional e compressão triaxial com vista à quantificação do fenómeno.
Neves, E. Maranha, Pinto, A. Veiga
openaire   +2 more sources

MITF maintains genome stability in nonmelanocyte lineages

open access: yesMolecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir   +13 more
wiley   +1 more source

Intensification of the Near Wall Collapsing Bubble Induced Jet Using an Opposite Secondary Wall

open access: yesJournal of Fluid Science and Technology, 2008
Effects of an opposite secondary wall for intensification of the liquid jet that is formed through the near wall bubble collapse were numerically investigated. The axisymmetric form of the Navier-Stokes equations was solved to predict the flow conditions
Roozbeh MOUSAVI Belfeh Teymouri   +1 more
doaj   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

open access: yesMolecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller   +10 more
wiley   +1 more source

Development of a Novel Extra-Articular Device for Reducing the Weight-Bearing of the Hip Joint

open access: yesJournal of Biomechanical Science and Engineering, 2006
The morbidity associated with idiopathic osteonecrosis of the femoral head (ION) is increasing. The primary goal of treatment for ION is to prevent collapse of the femoral head. With the exception of hip arthroplasties, current joint-preserving surgeries
Go YAMAKO   +4 more
doaj   +1 more source

Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control

open access: yesFEBS Open Bio, EarlyView.
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada   +5 more
wiley   +1 more source

Home - About - Disclaimer - Privacy