Results 61 to 70 of about 631,811 (246)

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

open access: yesFEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill   +6 more
wiley   +1 more source

Characterising plastic collapse of pipe bend structures [PDF]

open access: yes, 2006
Two recently proposed design by analysis criteria of plastic collapse based on plastic work concepts, the plastic work (PW) criterion and the plastic work curvature (PWC) criterion, are applied to a strain hardening pipe bend arrangement subject to ...
Li, Hongjun, Mackenzie, Donald
core   +3 more sources

MagmaFlow: A desktop platform for artificial intelligence‐driven expression analysis

open access: yesFEBS Open Bio, EarlyView.
MagmaFlow is a free, no‐code platform for gene expression analysis. It generates interactive volcano plots, links genes to literature, pathways, and diseases, prioritizes candidates using millions of publications, identifies affected biological processes, builds network diagrams, and exports publication‐ready figures and reports for macOS and Windows ...
Carlos E. Buss   +7 more
wiley   +1 more source

Explosive nucleosynthesis in core-collapse supernovae [PDF]

open access: yes, 2023
openLa tesi tratta i principali aspetti dell'evoluzione idrostatica delle stelle massicce e della fisica dell'esplosione delle supernovae di tipo core-collapse.
VOLPI, GAIA
core  

ATZ‐1 promotes DNA replication efficiency to maintain normal meiotic function

open access: yesFEBS Open Bio, EarlyView.
Absence of ATZ‐1 interferes with meiotic DNA replication and cell cycle function via CHK‐1. This causes downstream defects associated with DNA damage and genomic integrity. Taken together, this study suggests that ATZ‐1 influences DNA replication efficiency and cell cycle function to maintain normal meiotic function.
Taylin E. Gourley   +5 more
wiley   +1 more source

The buckling and collapse behaviour of saddle-supported cylinders - Keynote Lecture [PDF]

open access: yes, 2003
Recent work by the present authors on the collapse conditions for horizontal cylindrical saddle supported storage vessels is described and reviewed. Attention is directed to a range of geometries, typically R/t < 200, where plastic collapse type failure ...
Spence, J., Nash, D.H.
core   +3 more sources

The Role of Foreign Harem and Queen In The Fall of The Ottoman Empire: A Siyasah Shar'iyyah Perspective

open access: yesUlumuddin
The article from this research aims to explain the role of women and foreign women in the Ottoman government, which had positive and negative impacts on the Empire. At first, the role of women was not very prominent in government.
Rahmi Rahmi   +3 more
doaj   +1 more source

Detection of Collapse and Crystallization of Saccharide, Protein, and Mannitol Formulations by Optical Fibers in Lyophilization

open access: yesFrontiers in Chemistry, 2018
The collapse temperature (Tc) and the glass transition temperature of freeze-concentrated solutions (Tg') as well as the crystallization behavior of excipients are important physicochemical characteristics which guide the cycle development in freeze ...
Jacqueline Horn, Wolfgang Friess
doaj   +1 more source

Selective elimination of quiescent cancer cells by dequalinium chloride via ROS‐mediated ferroptosis

open access: yesFEBS Open Bio, EarlyView.
Dequalinium chloride (DQ) selectively eliminates quiescent cancer cells (QCCs) by amplifying mitochondrial ROS. QCCs exhibit elevated basal ROS and limited redox‐buffering capacity, making them vulnerable to further ROS increases. DQ‐induced ROS exceeds the tolerance threshold, triggering lipid peroxidation and ferroptosis, whereas proliferating cells ...
Kotaro Miyamoto   +14 more
wiley   +1 more source

[News Clip: Bridge collapse]

open access: yes, 1959
Video footage from the WBAP-TV station in Fort Worth, Texas to accompany a news story about the collapse of a Fort Worth ...
WBAP-TV (Television station : Fort Worth, Tex.)
core   +1 more source

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