Results 51 to 60 of about 48,052 (261)

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Wellbore stability analysis of layered shale based on the modified Mogi–Coulomb criterion

Petroleum, 2020
Borehole instability was frequently encountered during shale gas drilling. Most conventional models are not applicable to layered formation's wellbore stability analysis on account of anisotropic strength characteristic.
Xu Yang, Xiangchao Shi, Yingfeng Meng, Xiaoyong Xie   +3 more
doaj   +1 more source

Logarithmic scaling of the collapse in the critical Keller–Segel equation [PDF]

Nonlinearity, 2013
A reduced Keller-Segel equation (RKSE) is a parabolic-elliptic system of partial differential equations which describes bacterial aggregation and the collapse of a self-gravitating gas of brownian particles. We consider RKSE in two dimensions, where solution has a critical collapse (blow-up) if the total number of bacteria exceeds a critical value.
Dyachenko, Sergey A., Lushnikov, Pavel M., Vladimirova, Natalia   +2 more
openaire   +3 more sources

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

A Study of Charged Cylindrical Gravitational Collapse with Dissipative Fluid

Advances in High Energy Physics, 2017
The present works deals with gravitational collapse of cylindrical viscous heat conducting anisotropic fluid following the work of Misner and Sharp. Using Darmois matching conditions, the dynamical equations are derived and the effects of charge and ...
Sanjukta Chakraborty, Subenoy Chakraborty   +1 more
doaj   +1 more source

High‐Resolution MRI Revealed Different Etiology‐Specific Associations With Cerebral Infarction in Adult Moyamoya Vasculopathy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective High‐resolution MRI enables detailed assessment of intracranial vessel wall pathology in moyamoya vasculopathy. We aimed to classify adult moyamoya vasculopathy etiologies using high‐resolution MRI and to examine subtype‐specific associations between high‐resolution MRI features and ischemic infarction.
Guangsong Han, Jiachun Pan, Yuehui Hong, Xiaoyuan Fan, Ming Yao, Lixin Zhou, Yicheng Zhu, Feng Feng, Jun Ni   +8 more
wiley   +1 more source

There Is No Spooky Action at a Distance in Quantum Mechanics

Entropy, 2022
Einstein became bothered by quantum mechanical action at a distance within two years of Schrödinger’s introduction of his eponymous wave equation. If the wave function represents the “real” physical state of a particle, then the measurement of the ...
Stephen Boughn
doaj   +1 more source

Global Rather Than Vertical‐Selective Saccadic Abnormalities in Progressive Supranuclear Palsy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To test whether vertical saccades are preferentially affected in Progressive Supranuclear Palsy (PSP). Methods PSP patients (n = 24) were compared to age‐matched controls (n = 94) and two degenerative groups (Alzheimer's disease, n = 20; Lewy body disease, n = 50).
Duy Duan Nguyen, Mark Paine, Soohyun Lee, Amir Fazlollahi, Baibin (Ben) Wang, John D. O'Sullivan, Peter J. Nestor   +6 more
wiley   +1 more source

CONTRIBUTION TO THE THEORY OF CELL COLLAPSE IN WOOD: INVESTIGATIONS WITH EUCALYPTUS REGNANS

Maderas: Ciencia y Tecnología, 2002
Total collapse is considered as the sum of "liquid tension collapse" and "stress collapse". An equation is derived giving total collapse as a linear function of wood temperature and, to a smaller extent, of collapse-free shrinkage.
W. G KAUMAN
doaj  

Karl Popper and the Mechanisms of Hydrogen Embrittlement

Advanced Engineering Materials, EarlyView.
Representation of the beginning of loss of ductility rather than embrittlement. Small concentrations of hydrogen in a diffusible form within iron are well‐established to harm the mechanical integrity of steels. There are theories that attempt to explain the pernicious role of hydrogen.
H. K. D. H. Bhadeshia
wiley   +1 more source