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Heliyon, 2023 Aims: To explore the new indications and key mechanism of Bazi Bushen capsule (BZBS) by network pharmacology and in vitro experiment. Methods: The ingredients library of BZBS was constructed by retrieving multiple TCM databases.
Tongxing Wang +11 more
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Collateral Circulation in Ischemic Stroke: An Updated Review
Journal of Stroke, 2023 The collateral circulation plays a crucial role in maintaining perfusion to brain tissue in ischemic stroke, which prolongs the time window for effective therapies to be provided and ultimately avoids irreversible damage that may lead to worse clinical ...
G. Maguida, A. Shuaib
semanticscholar +1 more source
High-fidelity Cas13 variants for targeted RNA degradation with minimal collateral effects
bioRxiv, 2021 CRISPR–Cas13 systems have recently been used for targeted RNA degradation in various organisms. However, collateral degradation of bystander RNAs has limited their in vivo applications.
Huawei Tong +22 more
semanticscholar +1 more source
Antioxidants, 2022 Multiple sclerosis (MS) is an autoimmune-mediated degenerative disease of the central nervous system (CNS) characterized by immune cell infiltration, demyelination and axonal injury.
Zheng Zha +4 more
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Cerebral Collateral Circulation in the Era of Reperfusion Therapies for Acute Ischemic Stroke
Stroke, 2022 Clinical outcomes of patients with acute ischemic stroke depend in part on the extent of their collateral circulation. A good collateral circulation has also been associated with greater benefit of intravenous thrombolysis and endovascular treatment ...
Simone M. Uniken Venema +4 more
semanticscholar +1 more source
Frontiers in Pharmacology, 2022 Ischemic stroke elicits white matter injury typically signed by axonal disintegration and demyelination; thus, the development of white matter reorganization is needed. 2,3,5,6-Tetramethylpyrazine (TMP) is widely used to treat ischemic stroke. This study
Xue-Feng Feng +18 more
doaj +1 more source
Frontiers in Pharmacology, 2021 Trillium tschonoskii Maxim. (TTM), is a perennial herb from Liliaceae, that has been widely used as a traditional Chinese medicine treating cephalgia and traumatic hemorrhage.
Le Yang +20 more
doaj +1 more source
Effect and Mechanism of Catalpol on Remyelination via Regulation of the NOTCH1 Signaling Pathway
Frontiers in Pharmacology, 2021 Promoting the differentiation of oligodendrocyte precursor cells (OPCs) is important for fostering remyelination in multiple sclerosis. Catalpol has the potential to promote remyelination and exert neuroprotective effects, but its specific mechanism is ...
Yaqin Sun +6 more
doaj +1 more source
Collateral Circulation in Thrombectomy for Stroke After 6 to 24 Hours in the DAWN Trial
Stroke, 2021 Supplemental Digital Content is available in the text. Background and Purpose: Collaterals govern the pace and severity of cerebral ischemia, distinguishing fast or slow progressors and corresponding therapeutic opportunities.
D. Liebeskind +17 more
semanticscholar +1 more source
Frontiers in Cellular Neuroscience, 2023 2,3,5,6-Tetramethylpyrazine (TMP) as an active ingredient extracted from a traditional Chinese herbal medicine Ligusticum chuanxiong Hort. has been proved to penetrate blood-brain barrier (BBB) and show neuroprotective effects on cerebral ischemia ...
Xue-feng Feng +16 more
doaj +1 more source