Results 61 to 70 of about 3,115,714 (294)

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

L’édition des œuvres mathématiques au xixe siècle en Allemagne. L’exemple des Gesammelte Werke und wissenschaftlicher Nachlass de Bernhard Riemann

open access: yesPhilosophia Scientiæ, 2018
This paper studies the edition of mathematical collected works in the 19th century, by focusing on a case study—the edition of German mathematician B. Riemann’s collected works, by R. Dedekind and H. Weber.
Emmylou Haffner
doaj   +1 more source

Hopes and disappointments in the history. Collected works in memory of Professor Milchio Lalkov [PDF]

open access: yes, 2005
Christianity was deeply rooted among the Maltese well before the advent of the Order of St John in 1530. By the late Middle Ages Malta had developed into a diocese run by an absentee Bishop and an Inquisition tribunal that was usually presided over by ...
Cassar, Carmel
core  

VoxCeleb2: Deep Speaker Recognition

open access: yes, 2018
The objective of this paper is speaker recognition under noisy and unconstrained conditions. We make two key contributions. First, we introduce a very large-scale audio-visual speaker recognition dataset collected from open-source media.
Chung, Joon Son   +2 more
core   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

open access: yesFEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan   +5 more
wiley   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

A Novel Real-Time Non-invasive Hemoglobin Level Detection Using Video Images from Smartphone Camera [PDF]

open access: yes, 2017
Hemoglobin level detection is necessary for evaluating health condition in the human. In the laboratory setting, it is detected by shining light through a small volume of blood and using a colorimetric electronic particle counting algorithm.
Adibuzzaman, Mohammad   +6 more
core   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Collected traditions and scattered secrets. Eclecticism and esotericism in the works of the 14th century ashkenazi kabbalist Menahem Ziyyoni of Cologne

open access: yesNordisk Judaistik, 1999
There are many examples of authors of mystical works who consciously chose to retreat the role of copyists and collectors of already existing traditions.
Heidi Laura
doaj   +1 more source

The Everett Interpretation of Quantum Mechanics: Collected Works 1955-1980 with Commentary [Book Review] [PDF]

open access: yes, 2013
The so-called many-worlds interpretation of quantum mechanics is one of the main contenders in current approaches to solve the quantum-measurement problem.
Sauer, Tilman
core  

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