Results 71 to 80 of about 7,287,837 (290)
Review of Vasyl' Sokil, compiler and editor. Materialy do biohrafii [Materials Toward a Biography]. 2016. Mykhailo Zubryts'kyi: Zibrani tvory i materialy [Mykhailo Zubryts'kyi: Collected Works and Materials], editor-in-chief, Frank Sysyn, edited by ...
Ksenya Kiebuzinski
doaj +1 more source
Reconstructing enzyme evolution by protein engineering
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Cover title: Allied Works Council : report for the period July 1, 1943-February 15, 1915.; Electronic reproduction. Canberra, A.C.T. National Library of Australia, 2010.Allied Works Council : report for the period July 1, 1943-February 15 ...
Allied Works Council (Australia)
core
An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas +4 more
wiley +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Liver organoids: modelling complexity in homeostasis and disease
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
Presentation of the New Collected Works by A. N. Tolstoy
On October 17, 2024, a presentation of the first volume of the new collected works by A. N. Tolstoy took place at the A. N. Tolstoy’ Memorial Museum-Apartment on Spiridonovka.
Tatyana Ju. Kravchenko
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This 30-volume edition of the Collected Works of Russian-American sociologist Pitirim Aleksandrovich Sorokin (1889–1968), the publication of which is ongoing with support from the Komi Republic Government (Russian Federation), is unique and the most ...
Nikolay A. Golovin
doaj +1 more source
Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source

