Claudins in the Renal Collecting Duct [PDF]
International Journal of Molecular Sciences, 2019 The renal collecting duct fine-tunes urinary composition, and thereby, coordinates key physiological processes, such as volume/blood pressure regulation, electrolyte-free water reabsorption, and acid-base homeostasis.
Leiz, Janna, Schmitt-Ott, Kai M.
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Differentiated mouse kidney tubuloids as a novel in vitro model to study collecting duct physiology [PDF]
Frontiers in Cell and Developmental Biology, 2023 Kidney tubuloids are cell models that are derived from human or mouse renal epithelial cells and show high similarities with their in vivo counterparts. Tubuloids grow polarized in 3D, allow for long-term expansion, and represent multiple segments of the
C. J. A. Olde Hanhof +15 more
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Modus operandi of ClC-K2 Cl− Channel in the Collecting Duct Intercalated Cells [PDF]
Biomolecules, 2023 The renal collecting duct is known to play a critical role in many physiological processes, including systemic water–electrolyte homeostasis, acid–base balance, and the salt sensitivity of blood pressure.
Anna Stavniichuk +5 more
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A complete response to Pembrolizumab for metastatic collecting duct carcinoma of the kidney [PDF]
Urology Case ReportsCollecting duct carcinoma, also known as Bellini duct cancer, is a rare subtype of renal cell carcinoma with a poor prognosis in the metastatic setting.
Satoki Abe +5 more
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Collecting duct NCOR1 controls blood pressure by regulating mineralocorticoid receptor [PDF]
Journal of Advanced ResearchIntroduction: Nuclear receptor corepressor 1(NCOR1) is reported to play crucial roles in cardiovascular diseases, but its function in the kidney has remained obscure. Objective: We aim to elucidate the role of collecting duct NCOR1 in blood pressure (BP)
Ke Sun +8 more
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A rare case of collecting duct renal cell carcinoma [PDF]
Urology Case ReportsCollecting duct carcinoma is an exceptionally rare and aggressive form of renal cell carcinoma (RCC), representing between 0.4 and 1.8% of RCC cases. The most commonly affected demographic are young African-American males. Here, we present a rare case of
Vance Gentry +3 more
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Clear cell renal cell carcinoma with collecting duct carcinoma transformation: a case report and review of the literature [PDF]
BMC UrologyCollecting duct carcinoma (CDC), a rare and aggressive renal malignancy originating from the medullary collecting ducts, often presents with nonspecific symptoms and rapid metastatic progression, yielding a dismal prognosis. The occurrence of a composite
Mingwei Liang +4 more
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FAK–Src signalling is important to renal collecting duct morphogenesis: discovery using a hierarchical screening technique [PDF]
Biology Open, 2013 Summary This report describes a hierarchical screening technique for identification of pathways that control the morphogenesis of the renal collecting duct system. The multi-step screen involves a first round using a 2-dimensional, cell-line-based scrape-
Guangping Tai +2 more
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The evolving complexity of the collecting duct renin–angiotensin system in hypertension
Nature Reviews Nephrology, 2021 Minolfa Prieto +2 more
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Proteogenomic Analysis Identifies Clinically Relevant Subgroups of Collecting Duct Carcinoma [PDF]
ResearchCollecting duct carcinoma (CDC) is a rare but aggressive form of renal cell carcinoma (RCC) that has limited understanding and an undefined systemic therapeutic regimen. Herein, we conducted a comprehensive proteogenomic analysis of CDC tumors and normal
Yuanyuan Qu +22 more
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