Results 151 to 160 of about 1,532,862 (339)

Reappraisal of Morphologic Differences Between Renal Medullary Carcinoma, Collecting Duct Carcinoma, and Fumarate Hydratase–deficient Renal Cell Carcinoma

American Journal of Surgical Pathology, 2018
C. Ohe, Steven C. Smith, Deepika Sirohi, M. Divatia, M. D. de Peralta-Venturina, G. Paner, A. Agaimy, Mitual B. Amin, P. Argani, Ying-bei Chen, Liang Cheng, M. Colecchia, E. Compérat, Isabela Werneck da Cunha, J. Epstein, A. Gill, O. Hes, M. Hirsch, W. Jochum, L. Kunju, F. Maclean, C. Magi-Galluzzi, J. McKenney, R. Mehra, G. Nesi, A. Osunkoya, M. Picken, P. Rao, V. Reuter, P. G. de Oliveira Salles, L. Schultz, S. Tickoo, S. Tomlins, K. Trpkov, Mahul B. Amin   +34 more
semanticscholar   +1 more source

A Patient‐Derived Organ‐on‐Chip Platform for Modeling the Tumor Microenvironment and Drug Responses in Pancreatic Cancer

Advanced Science, EarlyView.
Researchers have developed a patient‐derived organ‐on‐a‐chip model for pancreatic cancer by integrating cancer cells with supportive stromal and immune cells inside a microfluidic device. This system mimics the tumor microenvironment, enabling personalized testing of chemotherapy and immunotherapy, and offering new insights into how targeting ...
Darbaz Adnan, Natan Roberto de Barros, Luca S. Santovito, Xuhong Cheng, Kristi M. Lawrence, Mariah K. Barnett, Martine D. Boetto, Neal Mehta, Ajaypal Singh, Lin Cheng, Xiangsheng Huang, Faraz Bishehsari   +11 more
wiley   +1 more source

Transcriptomes of major renal collecting duct cell types in mouse identified by single-cell RNA-seq

Proceedings of the National Academy of Sciences of the United States of America, 2017
Lihe Chen, Jae Wook Lee, C. Chou, A. Nair, M. Battistone, T. Paunescu, M. Merkulova, S. Breton, J. Verlander, S. Wall, Dennis Brown, M. Burg, M. Knepper   +12 more
semanticscholar   +1 more source

Endometrial Assembloid Model Reveals Endometrial Gland Development Regulation by Estradiol‐Driven WNT7B Suppression

Advanced Science, EarlyView.
This study developed a 3D endometrial assembloid model to study how uterine glands form and develop. They discovered key interactions between different cell types and identified WNT7B as a regulator controlled by estradiol‐mediated TGFβ1‐VDR interaction.
Xintong Li, Yanjie Guo, Jianlin Li, Yimeng Li, Leqian Lin, Hoi Kit Matthew Leung, Qingqing Zhang, Kai‐Fai Lee, Ka‐Wang Cheung, Ernest H. Y. Ng, William S. B. Yeung, Philip C. N. Chiu, Cheuk‐Lun Lee   +12 more
wiley   +1 more source

Biodegradable Carbonate Nanogels Loaded with Anti MFAP‐5 siRNA for Anti‐stromal Therapy of Hepatocellular Carcinoma

Advanced Science, EarlyView.
Polycarbonate nanogels enable lipid‐free delivery of anti‐MFAP‐5 siRNA into cancer‐associated fibroblasts (CAF) in hepatocellular carcinoma. In a cirrhotic murine model, this approach silences MFAP‐5, reduces fibroblast activation, and suppresses tumor growth by inhibiting NOTCH/Hes1‐driven angiogenesis. CAF‐targeted MFAP‐5 RNAi and conserved signaling
Paul Schneider, Alexander Fuchs, Michael Fichter, Vanessa Bolduan, Jenny Schunke, Özlem Akilli, Nádia C. Correia, Yannick Ehlers, Christian Czysch, Pia Winterwerber, Eliana Stanganello, Barbara Schrörs, Mustafa Diken, Christoph Eckert, Shusruto Rishik, Andreas Keller, Jörn M. Schattenberg, Stephan Grabbe, Matthias Bros, Lutz Nuhn, Leonard Kaps   +20 more
wiley   +1 more source

Lipidomic and proteomic analysis of exosomes from mouse cortical collecting duct cells

The FASEB Journal, 2017
Viet D Dang, K. K. Jella, R. Ragheb, N. Denslow, A. Alli   +4 more
semanticscholar   +1 more source

Lactylation‐Driven YTHDC1 Alleviates MASLD by Suppressing PTPN22‐Mediated Dephosphorylation of NLRP3

Advanced Science, EarlyView.
In MASLD, YTHDC1 undergoes increased lactylation and ubiquitination, reducing its expression. AARS1 mediates lactylation at lysine 565, while disrupted binding to LDHA further promotes lactylation, suppressing YTHDC1. This downregulation enhances PTPN22 mRNA stability, leading to NLRP3 dephosphorylation and activation, which exacerbates inflammation ...
Feng Zhang, Linghua Zeng, Kunkun Zou, Keying Lin, Fangting Yao, Jinglun Song, Shumeng Zhang, Hanshu Feng, Zhichao Yang, Chunlei Wang, Hongtao Diao, Xue Kong, Tengfei Pan, Joonki Kim, Tianqi Duo, Linqiang Li, Yu Bian   +16 more
wiley   +1 more source

HNF1B controls epithelial organization and cell polarity during ureteric bud branching and collecting duct morphogenesis

Development, 2017
Audrey Desgrange, Claire Heliot, I. Skovorodkin, S. Akram, Janne Heikkilä, Veli-Pekka Ronkainen, I. Miinalainen, S. Vainio, S. Cereghini   +8 more
semanticscholar   +1 more source

Organization of collecting duct intercalated cells

Kidney International, 1990
Our understanding of the mechanisms by which the collecting duct transports HCO3 continues to evolve rapidly. The models put forth in Figure 1, though esthetically pleasing by virtue of their simplicity, will undoubtedly require modification as the above areas and others continue to be explored.
openaire   +2 more sources

Targeting NRP1 in Endothelial Cells Facilitates the Normalization of Scar Vessels and Prevents Fibrotic Scarring

Advanced Science, EarlyView.
Scars exhibit vascular abnormal alterations, including upregulated NRP1 expression in endothelial cells, increased vascular density and branching, compromised vessel wall integrity, and incomplete pericyte coverage. Therapeutic targeting of NRP1 through hydrogel spray delivery offers a promising approach to normalize aberrant vasculature and prevent ...
Yu Wang, Xin Zhou, Min Liu, Meimei Huang, Peirong Chen, Xinying Li, Fangchao Xue, Wenyan Zhao, Di Liu, Lang Li, Yuangang Lu, Wen Zeng   +11 more
wiley   +1 more source