Results 201 to 210 of about 1,532,862 (339)

Aldosterone regulates microRNAs in the cortical collecting duct to alter sodium transport.

Journal of the American Society of Nephrology, 2014
R. Edinger, C. Coronnello, Andrew J. Bodnar, M. Labarca, Vivek Bhalla, W. LaFramboise, P. Benos, J. Ho, John P. Johnson, M. Butterworth   +9 more
semanticscholar   +1 more source

S3RL: Enhancing Spatial Single‐Cell Transcriptomics With Separable Representation Learning

Advanced Science, EarlyView.
Separable Spatial Representation Learning (S3RL) is introduced to enhance the reconstruction of spatial transcriptomic landscapes by disentangling spatial structure and gene expression semantics. By integrating multimodal inputs with graph‐based representation learning and hyperspherical prototype modeling, S3RL enables high‐fidelity spatial domain ...
Laiyi Fu, Penglei Wang, Gaoyuan Xu, Jitao Lu, Qinke Peng, Danyang Wu, Hequan Sun   +6 more
wiley   +1 more source

GOT1 Inhibition Induces Extracellular Matrix Remodeling in Pancreatic Cancer

Advanced Science, EarlyView.
Using tumor tissue engineering, we recreated pancreatic cancer and found that inhibiting glutamic‐oxaloacetic transaminase 1 (GOT1) induces extracellular matrix remodeling and secretome rewiring, as well as promotes cell death. ABSTRACT Pancreatic cancer cells rely on glutamine to sustain their survival in the stiff and poorly vascularized tumor ...
Rodrigo Curvello, Sandra Hauser, Michael Seifert, Christopher K. Barlow, Joel R. Steele, Emma Salisbury, Daniel Croagh, Kathryn S. Stok, Anna V. Taubenberger, Ralf B. Schittenhelm, Daniela Loessner   +10 more
wiley   +1 more source

Generation of Atp6v1g3-Cre mice for investigation of intercalated cells and the collecting duct.

Am J Physiol Renal Physiol, 2023
Saxena V, Arregui S, Zhang S, Canas J, Qin X, Hains DS, Schwaderer AL.   +6 more
europepmc   +1 more source

Deep Learning‐Powered Scalable Cancer Organ Chip for Cancer Precision Medicine

Advanced Science, EarlyView.
This scalable, low‐cost Organ Chip platform, made via injection molding, uses capillary pinning for hydrogel confinement and supports versatile tissue coculture and robust imaging. Deep learning enables label‐free, sensitive phenotypic analysis.
Yu‐Chieh Yuan, Beibei Xu, Jenna McCormack, XuHai Huang, Jingzhe Ma, Thomas Marshall, Yacong Sun, Hardeep Singh, Alyssa Fanelli, Gauri Kulkarni, Ji Hye Seo, Paige Gilbride, Bing Wei, Bo Wang, Yanyan Liu, Fei Ma, Lin Zhou, Shuyang Wang, Xiaohua Qian, Zhiyong Xie, Polina Golland, Longlong Si, Yu Shrike Zhang, Xin Xie, Haiqing Bai   +24 more
wiley   +1 more source

Exosomal transfer from human renal proximal tubule cells to distal tubule and collecting duct cells.

Clinical Biochemistry, 2014
J. Gildea, Joscelyn E Seaton, K. Victor, C. M. Reyes, Dora Bigler Wang, Abigail C Pettigrew, Crystal E Courtner, Neema J. Shah, Hanh T. Tran, R. V. Van Sciver, Julia M. Carlson, R. Felder   +11 more
semanticscholar   +1 more source

Targeting IL27RA Enhances Immunotherapy in Triple‐Negative Breast Cancer by Modulating Tumor Cells and the Tumor Microenvironment

Advanced Science, EarlyView.
IL27RA upregulation drives immune evasion in TNBC by suppressing MHC‐I expression and reprogramming T/NK‐cell states, establishing an immune‐excluded tumor phenotype. Targeting this epithelial‐intrinsic IL27RA–PI3K/AKT axis offers a promising strategy to overcome immunotherapy resistance.
Jiachi Xu, Qian Long, Meirong Zhou, Qitong Chen, Jing Peng, Qingchun Liang, Danhua Zhang, Hui Zhou, Wenjun Yi   +8 more
wiley   +1 more source

Proteome-wide measurement of protein half-lives and translation rates in vasopressin-sensitive collecting duct cells.

Journal of the American Society of Nephrology, 2013
P. Sandoval, D. Slentz, T. Pisitkun, F. Saeed, J. Hoffert, M. Knepper   +5 more
semanticscholar   +1 more source

Calcium Channel Blockers Inhibit Pancreatic Neuroendocrine Neoplasms Progression via Cav1.2‐Epigenetic Circuit

Advanced Science, EarlyView.
Our study reveals a novel mechanism of a positive regulatory circuit between Cav1.2 and H3K27ac for pancreatic neuroendocrine neoplasms (pNENs) progression. Cav1.2 is identified as a crucial target for promoting disease progression and correlates with malignant behaviors, which are remarkably inhibited by the administration of calcium channel blockers (
Yangyinhui Yu, Qiongcong Xu, Jinzhao Xie, Mingjian Ma, Xitai Huang, Yinhao Shi, Jiawei Zhou, Enliang Zhu, Ziyi Zhao, Ning Zhang, Zhide Liu, Jingyuan Ye, Xiaoyu Yin   +12 more
wiley   +1 more source

Surgery lengthens survival for collecting duct carcinoma: analysis of hospital-based cancer registry data in Japan. [PDF]

BMC Cancer
Kandori S, Suzuki S, Kojo K, Isoda B, Tanaka T, Nitta S, Shiga M, Nagumo Y, Ikeda A, Kawahara T, Hoshi A, Negoro H, Mathis BJ, Okuyama A, Nishiyama H.   +14 more
europepmc   +1 more source