Results 121 to 130 of about 95,573 (296)

Regulation of mammary gland branching morphogenesis by the extracellular matrix and its remodeling enzymes. [PDF]

, 2003
A considerable body of research indicates that mammary gland branching morphogenesis is dependent, in part, on the extracellular matrix (ECM), ECM-receptors, such as integrins and other ECM receptors, and ECM-degrading enzymes, including matrix ...
A Amour, A Garcia-Gasca, A Lochter, A Lochter, AC Andres, AJ D'Ardenne, AM Belkin, AR Nelson, B Lelongt, BL Hogan, BM Gumbiner, BS Wiseman, C Brisken, C Brisken, CJ Sympson, CS Atwood, CW Daniel, CW Daniel, D Alford, D Alford, DG Stupack, ED Hay, EW Thompson, F Berdichevsky, F Kheradmand, FE Jones, G Bani, G Giannelli, G Shyamala, GB Silberstein, GB Silberstein, GB Silberstein, GB Silberstein, GL Ganser, GW Robinson, GW Robinson, GW Robinson, H Birkedal-Hansen, H Joseph, HJ Hathaway, HY Ha, J Chen, J Lilla, J Muschler, J Russo, J Schlondorff, J Yant, JE Fata, JE Fata, JE Fata, JE Ferguson, JF Wiesen, JJ Wysolmerski, JJ Wysolmerski, JM Bradbury, JM Whitelock, JM Williams, JP Irigoyen, JP Lydon, JP Witty, JT Emerman, K Elenius, K Hotary, K Ito, K Morita, K Wolf, L Hennighausen, LA Rudolph-Owen, LA Rudolph-Owen, LJ van't Veer, LR Lund, M Affolter, M Durbeej, M Egeblad, M Rytomaa, M Simian, MA Arnaout, MD Infeld, MD Sternlicht, MF Horster, MH Barcellos-Hoff, MJ van de Vijver, MM Zutter, MM Zutter, MP Osborne, MR Crowley, MR Warner, MS Wicha, N Koshikawa, N Quarto, NJ Kenney, NK Wessells, OW Petersen, P Bashkin, PR Warfield, PY Desprez, R Lagace, RH Wetzels, RS Talhouk, S Coleman, S Mukherjee, S Selvarajan, S Sinha, S Stahl, SD Banerjee, SD Robinson, SE Baker, SH Barsky, SL Bullock, SM Ellerbroek, T Darribere, T Gudjonsson, T Hayakawa, T Hayakawa, T Hayakawa, TC Klinowska, TC Klinowska, TC Klinowska, TH Vu, TN Seagroves, U Felbor, V Gouon-Evans, V Noe, VM Weaver, W Ruan, W Wang, W Xie, WF Vogel, WF Vogel, WH Yu, WP Bocchinfuso, Y Fukuda, Y Fukuda, Y Hirai, Y Hirai, Y Kadono, Y Nakanishi, YS Kanwar, Z Werb, Z Zhu   +139 more
core   +2 more sources

A20 Facilitates Oxaliplatin Sensitivity in Colorectal Cancer Through Monoubiquitylation of IKK‐β

Advanced Science, EarlyView.
This study demonstrates that the expression of A20, a ubiquitin‐editing enzyme, is positively correlated with oxaliplatin sensitivity in colorectal cancer (CRC). Mechanistically, A20 enhances oxaliplatin sensitivity by inhibiting NF‐κB nuclear translocation through monoubiquitination of IKK‐β.
Fan Luo, Ting Yang, Jiaxin Cao, Qun Chen, Zhenhai Lu, Feiteng Lu, Chaozhuo Lin, Zengfei Xia, Yuanzhong Yang, Peng Li, Wenjuan Ma, Min Luo, Rongxin Zhang   +12 more
wiley   +1 more source

Interleukin‐18 signaling promotes activation of hepatic stellate cells in mouse liver fibrosis

Hepatology, EarlyView., 2022
Interleukin‐18 signaling promotes activation of hepatic stellate cells in mouse liver fibrosis. Abstract Background and Aims Nucleotide‐binding oligomerization domain‐like receptor‐family pyrin domain‐containing 3 (NLRP3) inflammasome activation has been shown to result in liver fibrosis.
Jana Knorr, Benedikt Kaufmann, Maria Eugenia Inzaugarat, Theresa Maria Holtmann, Lukas Geisler, Jana Hundertmark, Marlene Sophia Kohlhepp, Laela M. Boosheri, Daisy R. Chilin‐Fuentes, Amanda Birmingham, Kathleen M. Fisch, Joel D. Schilling, Sven H. Loosen, Christian Trautwein, Christoph Roderburg, Münevver Demir, Frank Tacke, Hal M. Hoffman, Ariel E. Feldstein, Alexander Wree   +19 more
wiley   +1 more source

Real‐Time In Vivo Cellular‐Level Imaging During Puncture

Advanced Science, EarlyView.
We present an artificial‐intelligence‐empowered integrative‐light‐field microendoscopy (AIM) needle that delivers real‐time in vivo, diffraction‐limited cellular‐level imaging during puncture and visualizes layered microstructures along the needle path. As a microscopic complement to CT/ultrasound, it improves sampling localization and adds preliminary
Huifang Gao, Jiakang Shao, Quanzhi Li, Yizhou Tan, Liangliang Huang, Xiaorong Xu, Ji Qi, Julin Xiao, Wenwen Li, Zhong Wen, Le Wang, Xu Liu, Qing Yang, Ying Gu   +13 more
wiley   +1 more source

c‐Rel–dependent Chk2 signaling regulates the DNA damage response limiting hepatocarcinogenesis

Hepatology, EarlyView., 2022
In response to genotoxic injury, c‐Rel upregulates ATM‐Chk2‐p53 pathway DNA damage proteins to limiting hepatocarcinogenesis. Abstract Background and Aims Hepatocellular carcinoma (HCC) is a leading cause of cancer‐related death. The NF‐κB transcription factor family subunit c‐Rel is typically protumorigenic; however, it has recently been reported as a
Jack Leslie, Jill E. Hunter, Amy Collins, Amelia Rushton, Lauren G. Russell, Erik Ramon‐Gil, Maja Laszczewska, Misti McCain, Marco Y. W. Zaki, Amber Knox, Yixin Seow, Laura Sabater, Daniel Geh, Neil D. Perkins, Helen L. Reeves, Dina Tiniakos, Derek A. Mann, Fiona Oakley   +17 more
wiley   +1 more source

Targeting Lactate and Lactylation in Cancer Metabolism and Immunotherapy

Advanced Science, EarlyView.
Lactate, once deemed a metabolic waste, emerges as a central regulator of cancer progression. This review elucidates how lactate and its epigenetic derivative, protein lactylation, orchestrate tumor metabolism, immune suppression, and therapeutic resistance.
Jiajing Gong, Yuhang Xie, Zhijie Weng, Yongzhi Wu, Longjiang Li, Bo Li   +5 more
wiley   +1 more source

TP53 R249S mutation in hepatic organoids captures the predisposing cancer risk

Hepatology, EarlyView., 2022
The systematic approach in elucidating the gain‐of‐function (GOF) roles of TP53 mutations in early liver carcinogenesis. Unique downstream targets of TP53 L3 mutations were identified from chormatin immunoprecipitation sequencing in HCC cell lines, followed by a series of validation assays to substantiate the exclusive transcriptional regulations ...
Yin Kau Lam, Jianqing Yu, Hao Huang, Xiaofan Ding, Alissa M. Wong, Howard H. Leung, Anthony W. Chan, Kelvin K. Ng, Mingjing Xu, Xin Wang, Nathalie Wong   +10 more
wiley   +1 more source

Targeting the vasopressin type-2 receptor for renal cell carcinoma therapy. [PDF]

, 2020
Arginine vasopressin (AVP) and its type-2 receptor (V2R) play an essential role in the regulation of salt and water homeostasis by the kidneys. V2R activation also stimulates proliferation of renal cell carcinoma (RCC) cell lines in vitro.
Calvet, James P, Dwivedi, Nidhi, Enders, Jonathan, Jamadar, Abeda, Kakade, Vijayakumar R, Neil, Maura O', Rao, Reena, Sinha, Sonali, Tao, Shixin, Thomas, Sufi M, Weiss, Robert H   +10 more
core  

GOT1 Inhibition Induces Extracellular Matrix Remodeling in Pancreatic Cancer

Advanced Science, EarlyView.
Using tumor tissue engineering, we recreated pancreatic cancer and found that inhibiting glutamic‐oxaloacetic transaminase 1 (GOT1) induces extracellular matrix remodeling and secretome rewiring, as well as promotes cell death. ABSTRACT Pancreatic cancer cells rely on glutamine to sustain their survival in the stiff and poorly vascularized tumor ...
Rodrigo Curvello, Sandra Hauser, Michael Seifert, Christopher K. Barlow, Joel R. Steele, Emma Salisbury, Daniel Croagh, Kathryn S. Stok, Anna V. Taubenberger, Ralf B. Schittenhelm, Daniela Loessner   +10 more
wiley   +1 more source

Deep Learning‐Powered Scalable Cancer Organ Chip for Cancer Precision Medicine

Advanced Science, EarlyView.
This scalable, low‐cost Organ Chip platform, made via injection molding, uses capillary pinning for hydrogel confinement and supports versatile tissue coculture and robust imaging. Deep learning enables label‐free, sensitive phenotypic analysis.
Yu‐Chieh Yuan, Beibei Xu, Jenna McCormack, XuHai Huang, Jingzhe Ma, Thomas Marshall, Yacong Sun, Hardeep Singh, Alyssa Fanelli, Gauri Kulkarni, Ji Hye Seo, Paige Gilbride, Bing Wei, Bo Wang, Yanyan Liu, Fei Ma, Lin Zhou, Shuyang Wang, Xiaohua Qian, Zhiyong Xie, Polina Golland, Longlong Si, Yu Shrike Zhang, Xin Xie, Haiqing Bai   +24 more
wiley   +1 more source