Results 191 to 200 of about 3,285,076 (268)

Socioeconomic determinants of leprosy in Brazilian municipalities: an ecological study. [PDF]

An Bras Dermatol
Golineli AOG, Belli MCV, Lourenço GH, Belli O, Miot HA.   +4 more
europepmc   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Mapping the Landscape of Open Access Dashboards - A Dataset for Research and Infrastructure Development. [PDF]

Sci Data
Schneider J, Pampel H.
europepmc   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

A prospective, observational, cost of implementation analysis for the National Infection Surveillance Program for Aged Care (NISPAC). [PDF]

Antimicrob Resist Infect Control
Brusco N, Whittaker S, Thursky K, Dunt D, Sluggett JK, Bull A, Worth LJ, Bennett N.   +7 more
europepmc   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Stress Coping and Psychological Resilience Development in Newly Licensed Registered Nurses During the Transition to Independent ICU Practice: A Descriptive Qualitative Study [Letter]. [PDF]

Psychol Res Behav Manag
Liu X, Ning L.
europepmc   +1 more source

Mood in the moment: a study protocol for embedding ecological momentary assessments into established longitudinal cohorts to examine depression in real time. [PDF]

BMJ Open
Kwong ASF, Moody S, Taylor A, Lockhart C, Ogden R, Leal R, Mcmillan A, Harvey J, Brierley E, Matthews S, Hobbs R, Simmons A, Eley TC, Jacobson NC, Murray AL.   +14 more
europepmc   +1 more source

Competency and Role Development in Advanced Nursing Practice Following a Swiss Master's Cohort Through Education and Early Clinical Practice: Protocol for a Longitudinal Convergent Mixed Methods Study. [PDF]

JMIR Res Protoc
Braun A, Fringer A, Gattinger H, Eissler C, Zumstein-Shaha M, Beer T, Roes M.   +6 more
europepmc   +1 more source