Results 31 to 40 of about 3,971,747 (262)

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Trends in hepatitis C virus seroprevalence and associated risk factors among msm in Pakistan: insights from a community-based study

Scientific Reports
Pakistan bears a substantial burden of hepatitis C virus (HCV) infection, with the second-highest prevalence globally. This community-based cross-sectional study, conducted from January to December 2022 in Punjab, Pakistan, investigates the ...
Raza Tirmizi, Rimsha Munir, Nousheen Zaidi   +2 more
doaj   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Hope and Anger as Mediators Between Collective Action Frames and Participation in Collective Mobilization: The Case of 15-M

Journal of Social and Political Psychology, 2017
The study set out to integrate collective action models and emphasize the role of emotions. Whereas the importance of anger is indisputable, relatively little attention has been paid to the role of positive emotions, such as hope, in collective action ...
Anna Wlodarczyk, Nekane Basabe, Darío Páez, Larraitz Zumeta   +3 more
doaj   +1 more source

Exploring social movement concepts and actions in a knowledge uptake and sustainability context: A concept analysis

International Journal of Nursing Sciences, 2022
Objectives: To share a concept analysis of social movement aimed at advancing its application to evidence uptake and sustainability in health-care. Methods: We applied Walker and Avant method to clarify the concept of social movement in the context of ...
Doris Grinspun, Katherine Wallace, Shelly-Anne Li, Susan McNeill, Janet Elaine Squires, Jesús Bujalance, Maryanne D’Arpino, Gina De Souza, Nataly Farshait, John Gabbay, Ian D. Graham, Alison Hutchinson, Kim Kinder, Celia Laur, Tina Mah, Julia E. Moore, Jennifer Plant, Jodi Ploquin, P. Jim A. Ruiter, Daphney St-Germain, Margie Sills-Maerov, May Tao, Marita Titler, Junqiang Zhao   +23 more
doaj   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Modes of Collective Action in Village Economies: Evidence from Natural and Artefactual Field Experiments in a Developing Country [PDF]

Asian Development Review, 2013
In a canonical model of collective action, individual contribution to collective action is negatively correlated with group size. Yet, empirical evidence on the group size effect has been mixed, partly due to heterogeneities in group activities.
Yasuyuki Sawada, Ryuji Kasahara, Keitaro Aoyagi, Masahiro Shoji, Mika Ueyama   +4 more
doaj   +1 more source

Psychological Determinants of Collective Action for Climate Justice: Insights From Semi-Structured Interviews and Content Analysis

Frontiers in Psychology, 2021
Student initiatives for climate justice are driving forces in the climate change debate, but the psychological determinants of students’ engagement for climate justice have hardly been investigated so far.
Hannah Bührle, Joachim Kimmerle, Joachim Kimmerle   +2 more
doaj   +1 more source

Decoding the dynamic extracellular matrix in cancer—3D models and bioscaffolds rewire the rules of tumor progression

FEBS Letters, EarlyView.
Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani, Konstantinos Spanopoulos, Zoi Piperigkou, Nikos K. Karamanos   +3 more
wiley   +1 more source