Results 41 to 50 of about 5,280,218 (348)

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

On the preconditions for large-scale collective action

Ambio, 2019
The phenomenon of collective action and the origin of collective action problems have been extensively and systematically studied in the social sciences.
Sverker C. Jagers, Niklas Harring, Åsa Löfgren, Martin Sjöstedt, F. Alpízar, B. Brülde, D. Langlet, A. Nilsson, B. C. Almroth, S. Dupont, W. Steffen   +10 more
semanticscholar   +1 more source

Underrepresented developing States, marginalized communities, big business and procedural injustice – how equal were the UN INC-5.2 Global Plastic Treaty negotiations?

Cambridge Prisms: Plastics
Negotiations by more than 180 States during the Intergovernmental Negotiating Committee (INC) session 5.2 to develop a legally binding instrument with the purpose to end plastic pollution have, once again, concluded without a treaty.
Tim Kiessling, Sabine Rech, Klaus Reus, Tony R. Walker   +3 more
doaj   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Geospatial mapping of microbial contaminants and public health risks in Lahore’s municipal water

Scientific Reports
Ensuring access to safe drinking water remains a significant public health challenge in developing countries. This study systematically investigates coliform contamination in Lahore’s municipal water supply, examining its public health implications ...
Rida Rashid, Farhad Ali Shah, Rimsha Munir, Asim Iqbal, Wajiha Javed, Rida Batool, Ameem Lutfi, Nousheen Zaidi   +7 more
doaj   +1 more source

Toward care-full plural agroecologies: Lessons from the U.S. Agroecology Summit 2023

Journal of Agriculture, Food Systems, and Community Development
First paragraphs: In May 2023, approximately 100 people gathered in Kansas City, Missouri, for a national conven­ing on scaling agroecology in what is now known as the United States.
Catherine Horner, Karen Crespo Triveño, Ana Fochesatto, Antonio Roman-Alcalá, Ivette Perfecto   +4 more
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Supporting the Upscaling of Citizen Science to Address Global Challenges

Citizen Science: Theory and Practice
In May 2024, a workshop was held as part of the European Citizen Science Association (ECSA) 2024 conference in Vienna to explore the creation of transnational communities to upscale citizen science, to address global issues as outlined by the European ...
James Christopher Sprinks, Liz Dowthwaite, Luigi Ceccaroni, Tim Kiessling, Dilek Fraisl, Giovanni Maccani, Ana Solange Leal, Agueda Gras-Velazquez, Arianna Liconti, Katarzyna Pydzinska Azevedo, Kaushiki Das, Stephen Parkinson, Mariana Malta   +12 more
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Trends in hepatitis C virus seroprevalence and associated risk factors among msm in Pakistan: insights from a community-based study

Scientific Reports
Pakistan bears a substantial burden of hepatitis C virus (HCV) infection, with the second-highest prevalence globally. This community-based cross-sectional study, conducted from January to December 2022 in Punjab, Pakistan, investigates the ...
Raza Tirmizi, Rimsha Munir, Nousheen Zaidi   +2 more
doaj   +1 more source