Results 51 to 60 of about 1,687,944 (295)

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Unplanned Coordination: Ensemble Improvisation as Collective Action

open access: yesJournal of Social Ontology, 2022
The characteristic features of ensemble dance improvisation (EDI) make it an interesting case for theories of intentional collective action. These features include the high degree of freedom enjoyed by each individual, and the lack of fixed hierarchical
Ali Hasan, Jennifer Kayle
doaj  

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

COMPLEX COLLECTIVE DUTIES & ACTION-GUIDANCE

open access: yesKriterion
We can often find in the literature (both popular and academic) ascriptions of complex collective duties to extensive unstructured collections of individuals.
Cristian Rettig
doaj   +1 more source

Grass Roots Collective Action: Agricultural Opportunities

open access: yesJournal of Agricultural and Resource Economics, 1997
Agroenvironmental problems (e.g., contamination of ground- and surface water, feed lot odors, endangered species) often involve goods and activities with public goods attributes.
Harry W. Ayer
doaj   +1 more source

Water governance and institutional change [PDF]

open access: yes, 2004
This dissertation is about water governance and institutional change. The focus on water governance means that we are interested in collective action with respect to water issues, which is not restricted to government action by public authorities, but ...
Kuks, S.M.M.
core   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

open access: yesFEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto   +3 more
wiley   +1 more source

Morality, Friendship, and Collective Action

open access: yesJournal of Social Ontology
This paper uses the tools of experimental philosophy to examine the nature of interpersonal normativity in collective action, focusing on cases of immoral collective action and collective action by friends.
Javier Gomez-Lavin, Matthew Rachar
doaj   +1 more source

Collective Action Federalism: A General Theory of Article I, Section 8 [PDF]

open access: yes, 2010
The Framers of the United States Constitution wrote Article I, Section 8 in order to address some daunting collective action problems facing the young nation.
Cooter, Robert D., Siegel, Neil S.
core   +1 more source

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

open access: yesFEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga   +3 more
wiley   +1 more source

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